The relationship between Thiol/Disulphide Homeostasis and Fibromyalgia

Ekinci, Bilge; Baran, Pervin; Bıçer, Cemile; Haliloğlu, Sema; Uzkeser, Hülya; Çarlıoğlu, Ayşe

doi:10.5455/annalsmedres.2019.12.860

Cited by 3 publications

(5 citation statements)

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“…Moreover, the number of smokers between the two groups in our analysis was more homogeneous because it is known that smoking would affect these levels [14]. In addition, unlike our findings, in a poster presentation in which the thiol/disulphide haemostasis was investigated in fibromyalgia, the thiol levels were found to be low, whereas the disulphide levels were high; however, because this poster presentation was not turned into a study, the material method part was not clearly understood in detail [15]. In addition, the patients in the fibromyalgia group may be older, have more comorbid disease, and be more intensively smoking than those in the control group.…”

Section: Discussioncontrasting

confidence: 72%

Dynamic thiol and disulphide homoeostasis in fibromyalgia

Karataş¹,

Gündüz²,

Haskul³

et al. 2020

aoms

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Introduction: Thiol and disulphide levels are biomarkers that provide useful information about oxidative stress and antioxidant capacity, showing a different homoeostasis in inflammatory and proliferative diseases. We aimed to clarify the possible aetiology of this disease by using thiol and disulphide levels in patients with fibromyalgia, the basis of which has not yet been clearly elucidated. Material and methods: A total of 156 individuals: 86 patients with fibromyalgia and 70 age-matched controls were included in this prospective non-randomised case-control study. Demographic characteristics including smoking status, body mass index (BMI), the duration of complaints, and pain levels were carefully recorded. Dynamic thiol-disulphide homoeostasis in blood samples was determined by an automatic-spectrophotometric method. The Mann-Whitney U and Student's t-test were used to determine the differences between the groups. Results: Sex, BMI, and smoking status were similar between the groups (p = 0.62, p = 0.09, and p = 0.64, respectively). While native thiol levels were found to be high in patients with fibromyalgia (p = 0.018), disulphide levels and the rates of disulphide/native thiol and disulphide/total thiol were significantly low (p = 0.049, p = 0.007, and p = 0.007, respectively). Correlation analysis showed no significant relationship between thiol-disulphide levels and duration of complaints or pain level. Conclusions: Thiol-disulphide balance in fibromyalgia was found to be similar to benign proliferative diseases, suggesting that the underlying mechanism is more likely to be of proliferative pattern rather than inflammatory. Additionally, fibromyalgia is not directly associated with increase in oxidative stress. The molecular mechanisms need to be elucidated.

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Section: Discussioncontrasting

confidence: 72%

Dynamic thiol and disulphide homoeostasis in fibromyalgia

Karataş¹,

Gündüz²,

Haskul³

et al. 2020

aoms

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“…In addition, they found a correlation between the FIQ scores and oxidative markers [15]. Ekinci et al conducted a comparable evaluation of the thiol-SS balance in FMS and found a similar tendency towards the oxidative side [17]. We found that the thiol-SS balance shifted to the SS side, which is the oxidative side, in FMS patients.…”

Section: Discussionsupporting

confidence: 65%

“…This balance is disturbed in many diseases where oxidative stress is thought to be involved in the pathophysiological mechanisms [13]. Although various studies have evaluated the thiol-SS balance in FMS, the findings are contradictory, and conflicting results have emerged regarding its correlation with clinical scales of FMS [10,15,17]. Fidan et al evaluated the thiol-SS balance in FMS and found a shift towards antioxidants in the FMS group [10].…”

Section: Discussionmentioning

confidence: 99%

“…This is an easy, inexpensive, practical, fully automated, and optionally manual spectrophotometric process that evaluates SS homeostasis [14]. Research on the thiol-SS balance in fibromyalgia is limited, and conflicting results have been reported [10,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have demonstrated the presence of oxidative stress in FMS, using different parameters [5]; however, the findings from studies on the thiol-SS balance are still contradictory [10,17]. We primarily aimed to evaluate thiol-SS homeostasis in patients with FMS compared to healthy controls.…”

Section: Introductionmentioning

confidence: 99%

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Thiol-Disulfide Balance in Fibromyalgia: A Case-Control Study

Sahingoz Bakirci,

Nacir,

Alisik

et al. 2024

Galician med. j.

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Aim. We aimed to examine the thiol-disulfide (SS) balance, a recognized marker of oxidative stress, in fibromyalgia syndrome (FMS). Methods. The study comprised 98 female participants (61 newly diagnosed patients and 37 patients under treatment) with FMS, along with 82 apparently healthy female volunteers. In both groups, assessments were conducted using the Fibromyalgia Impact Questionnaire (FIQ), Visual Analogue Scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Short Form-36 (SF-36), Tender Point Count, Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). Native thiol (NT) and total thiol (TT) levels were measured, SS levels and SS/NT ratio were calculated. Results. FMS patients demonstrated significantly lower NT levels, higher SS levels, and an elevated SS/NT ratio compared to the control group (p< 0.05 for all groups). In FMS patients, a statistically significant correlation was found between SS level and the SS/NT ratio, as well as the number of tender points (r=-0.24, p=0.02; r=-0.21, p=0.04), SF-36 pain subscales (r=0.22, p=0.032; r=0.21, p=0.04), and BAI scores (r=-0.22, p=0.01; r=-0.23 p=0.03). In the subgroup analysis, all health assessment scales were observed to exhibit statistically significant differences between the under-treatment group and newly-diagnosed group when compared to the control group (p< 0.05 for all groups). The FIQ, VAS, FSS, and BAI scores were found to be significantly lower in the under-treatment group as compared to the newly-diagnosed group (p< 0.05 for all groups). In the newly-diagnosed group, NT was significantly lower and the SS/NT ratio was significantly higher than those in the control group (p< 0.05). In the under-treatment group, SS levels and SS/NT ratio were significantly higher as compared to the control group (p< 0.05). In the multivariate regression analysis, which incorporated age, health assessment scales, patient subgroups, tender points, and duration of symptoms to predict the SS/NT ratio, variabes such as being in the under-treatment group, tender points, and BAI score were identified as significant predictors (p< 0.05). Conclusions. The thiol-SS balance was observed to shift in the oxidative direction, and oxidative stress was higher in the FMS group. The absence of a significant difference between the under-treatment group and the newly-diagnosed group in terms of thiol-SS balance parameters suggests a shift to oxidative stress in patients, independent of the treatment status.

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Can the Monocyte-To-HDL Ratio be Used as an Inflammation Marker in Patients with Fibromyalgia Syndrome?

Erden,

Turk,

Erden

2023

Nigerian Journal of Clinical Practice

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Background and Aim: The monocyte-to-high-density lipoprotein (HDL) ratio (MHR) may be used as a marker of inflammation and oxidative stress. This study aimed to evaluate the use of MHR and platelet markers in patients with fibromyalgia syndrome (FMS) and demonstrate MHR’s relationship with inflammation, the Fibromyalgia Impact Questionnaire (FIQ), and quality of life. Materials and Methods: Ninety FMS patients and 90 healthy controls, whose clinical and laboratory evaluations were performed simultaneously, were included in the study. The monocyte, platelet, HDL, MHR, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), mean platelet volume (MPV), and platelet distribution width (PDW) values of all patients were evaluated. The quality of life of the participants was assessed using the FIQ and their general health using the health assessment questionnaire (HAQ). Results: Age, body mass index (BMI), and marital status distribution were similar in both groups. The FMS patients had a mean disease duration of 11.29 ± 2.62 months. The median monocyte, platelet, MPV, visual analog scale (VAS), FIQ, and HAQ values and the mean MHR of the FMS patients were significantly higher than the control group, while the mean HDL level was significantly lower (P < 0.05). There was a weak negative correlation between the MPV and HAQ score and the PDW and HAQ score (rs = −0.225, P = 0.042 and rs = −0.249, P = 0.024, respectively), whereas no correlation was detected between the MHR and the FIQ and HAQ scores in FMS patients. According to the receiver operating characteristic curve analysis, MHR had prediction of FMS (P = 0.002; sensitivity = 0.63, specificity = 0.50, cut-off point ≥8.4). Conclusions: Our results suggest that the monocyte, platelet, HDL, MHR, and MPV parameters can be used in the evaluation of inflammation in FMS patients.

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The relationship between Thiol/Disulphide Homeostasis and Fibromyalgia

Cited by 3 publications

References 0 publications

Dynamic thiol and disulphide homoeostasis in fibromyalgia

Dynamic thiol and disulphide homoeostasis in fibromyalgia

Thiol-Disulfide Balance in Fibromyalgia: A Case-Control Study

Can the Monocyte-To-HDL Ratio be Used as an Inflammation Marker in Patients with Fibromyalgia Syndrome?

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