The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects

Gu, Yeqing; Li, Huihui; Bao, Xue; Zhang, Qing; Liu, Li; Meng, Guang; Wang, Hongmei; Du, Huanmin; Shi, Hongbin; Yang, Xia; Su, Qian; Fang, Liyun; Yu, Fei; Yang, Huijun; Yu, Bin; Sun, Shaomei; Wang, Xing; Zhou, Ming; Jia, Qiyu; Guo, Qi; Chang, Hong; Wang, Guolin; Huang, Guowei; Song, Kun; Niu, Kaijun

doi:10.1210/jc.2016-2965

Cited by 82 publications

(92 citation statements)

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“…This analysis used data from the Tianjin Chronic Low‐grade Systemic Inflammation and Health (TCLSIH) Cohort, which is a large prospective cohort study of inhabitants living in Tianjin, China. An extensive description of the objectives, rationale, and methods of TCLSIH was reported elsewhere (Gu et al, ). In short, the cohort was based on annual health examinations conducted in Tianjin Medical University General Hospital Health Management Center and focused on the relationship between chronic low‐grade systemic inflammation and health status.…”

Section: Methodsmentioning

confidence: 99%

Distinct associations of computer/mobile devices use and TV watching with depressive symptoms in adults: A large population study in China

Bao

et al. 2019

Depress Anxiety

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Background Recent evidence shows that screen time may be an important risk factor for mental health. The aim of this study was to examine the association of computer/mobile devices (CMD) use and TV watching separately with depressive symptoms in a large representative sample of Chinese adults. Methods A sample of 18,994 adults in Tianjin, China was studied in a cross‐sectional analysis. Depressive symptoms were assessed using the Self‐Rating Depression Scale (SDS). CMD use and TV watching time were self‐reported and divided into five categories. The associations were estimated by odds ratios (ORs) using logistic regression models adjusted for multiple confounders. Results The prevalence of elevated depressive symptoms was 16.3% (SDS ≥ 45). For CMD use, the ORs of the depressive symptoms decreased across time levels. Compared with the least use time (<1 hr/day), multivariable‐adjusted ORs (95% confidence interval [CI]) of other time categories for elevated depressive symptoms were 0.78 (0.66, 0.91), 0.67 (0.57, 0.80), 0.65 (0.54, 0.77), and 0.77 (0.62, 0.96) respectively. For TV watching, the ORs of the depressive symptoms increased across time levels. Compared with the least watching time (<1 hr/day), multivariable‐adjusted ORs (95% CI) for elevated depressive symptoms across the time categories were 1.00 (0.89, 1.12), 1.28 (1.11, 1.48), 1.26 (0.98, 1.60), and 1.95 (1.10, 3.35), respectively. Conclusions These findings suggested that different types of screen time may play different roles in the mental health of general adults. Further studies are needed to clarify the reasons for these distinct associations.

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Section: Methodsmentioning

confidence: 99%

Distinct associations of computer/mobile devices use and TV watching with depressive symptoms in adults: A large population study in China

Bao

et al. 2019

Depress Anxiety

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“…Participants, who had received health examinations, and had completed questionnaires regarding their smoking and drinking habits and disease history over the course of January 2007 to December 2016, were recruited. Moreover, a detailed lifestyle questionnaire was administered to randomly selected subjects from this population since May 2013 …”

Section: Methodsmentioning

confidence: 99%

Relationship between thyroid function and elevated blood pressure in euthyroid adults

Zheng

Zhang

et al. 2018

J of Clinical Hypertension

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Thyroid hormones (THs) have profound effects on cardiovascular functions, suggesting that THs may contribute to the development of elevated blood pressure (BP). Few studies, however, have systematically assessed the relationship between THs and elevated BP. We therefore conducted a cross-sectional study to examine how serum THs concentrations are related to the prevalence of elevated BP in a euthyroid population. This study (n = 12 487) was performed in Tianjin, China. Serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) levels were measured by chemiluminescence immunoassay. Elevated BP was defined according to the JNC 8 criteria. Analysis of covariance and multiple logistic regression models were used to assess the relationships between FT3, FT4, and TSH quartiles and elevated BP. The multivariable-adjusted odds ratios (95% confidence interval) of elevated BP for gradual increase in the FT3, FT4, and TSH quartiles, when compared to the lowest quartiles were 1.08 (0.97, 1.21), 1.24 (1.12, 1.39), and 1.32 (1.18, 1.47); 1.18 (1.06, 1.32), 1.18 (1.06, 1.31), and 1.24 (1.11, 1.38); 1.06 (0.96, 1.19), 1.06 (0.95, 1.18), and 1.03 (0.93, 1.15), respectively. Our study demonstrated that FT3 and FT4 are positively related to the prevalence of elevated BP in euthyroid adults, but no significant relationship was found between TSH and elevated BP.

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“…Besides the association between thyroid dysfunction, in particular hypothyroidism, and T2DM [4, 6, 7], increasing plasma thyroid stimulating hormone (TSH) levels within the normal range are also associated with the prevalence of T2DM in a cross-sectional study in a general adult population in China [16]. Two longitudinal studies, from the Netherlands and Korea, show conflicting results [17–19].…”

Section: Introductionmentioning

confidence: 99%

Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus

et al. 2018

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AimTo evaluate the relationship between thyroid-stimulating hormone (TSH) levels within the normal range and the risk of type 2 diabetes mellitus (T2DM) in a cohort of patients at high cardiovascular risk, and to perform a systematic review and meta-analysis of previous studies.MethodsWe included 5542 patients without T2DM from the prospective Secondary Manifestations of ARTerial disease study with TSH levels between 0.35 and 5.0 mIU/L without anti-thyroid medication or thyroid-hormone replacement therapy. Cox regression was used to investigate the relationship between baseline plasma TSH levels and incident T2DM. MEDLINE, EMBASE, and Cochrane were searched for prospective cohorts assessing TSH and incident T2DM. Hazard ratios (HR) from included prospective cohort studies were pooled using a random-effects model.ResultsIn patients at high cardiovascular risk, higher plasma TSH levels in the normal range were not associated [HR 1.07 per mIU/L increase in TSH (95% confidence interval (95% CI) 0.95–1.22)] with an increased risk of T2DM, adjusted for age, sex, smoking, total and HDL cholesterol, and triglycerides. In the meta-analysis involving three prospective cohort studies, including the present study, including 29,791 participants with 1930 incident events, there was no relation between plasma TSH levels in the normal range and incident T2DM [pooled HR 1.06 (95% CI 0.99–1.14)].ConclusionThere is no apparent relation between plasma TSH levels in the normal range and incident T2DM in patients at high cardiovascular risk.Electronic supplementary materialThe online version of this article (10.1007/s00592-018-1231-y) contains supplementary material, which is available to authorized users.

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The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects

Abstract: This study demonstrated that decreased FT3, FT3/FT4 ratios, and increased FT4 levels are independently related to a higher prevalence of T2DM in both males and females, and TSH is inversely related to T2DM in males only.

Cited by 82 publications

References 50 publications

Distinct associations of computer/mobile devices use and TV watching with depressive symptoms in adults: A large population study in China

Distinct associations of computer/mobile devices use and TV watching with depressive symptoms in adults: A large population study in China

Relationship between thyroid function and elevated blood pressure in euthyroid adults

Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus

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