The relationship between TNF alpha gene polymorphisms (−238/−308), TNF RII VNTR (p75) and outcomes of hepatitis B virus infection in Tunisian population

Association of TNF-α Gene Polymorphisms with Production of Protein and Susceptibility to Chronic Hepatitis B Infection in the South East Iranian Population

“…They highlighted the key role of -308 A/G polymorphism both in susceptibility to HBV infection and increased serum TNF-α level in HBV patients and emphasized that the presence of G at the position -308 increased the risk of HBV infection. However, our findings were different from the results of some studies (41-43) claiming that the A allele may have a role in HBV aggravation. In addition, Somi et al (44) found that TNF-α promoter polymorphism -308 was common in Iranian population, but they did not find any association between this SNP and development of chronic HBV infection.…”

Association between cytokine gene polymorphisms and outcome of hepatitis B virus infection in southern Brazil

“…Here, a positive correlation was found between TNF‐α‐308 polymorphism and chronic infection: carriers of AA and GA genotypes were 1.8 times more likely to become hepatitis B chronic patients than the others (OR, 1.82; 95%CI, 1.01–3.27; P = 0.046). This finding was in agreement with those recently found in Brazil [Ferreira et al, ] and North Africa (Tunisia) [Sghaier et al, ] where the carriers of the minor allele ‐308A showed an increased risk of developing chronic hepatitis B. Moreover, two other Brazilian studies [Conde et al, ; Teixeira et al, ] demonstrated that the −308A allele enhanced the risk of disease severity (progression to cirrhosis and HCC).…”

“…The outcome of infection is thought to depend on viral, environmental and host genetic factors. Due to the key role of cytokine expression levels in the immunoregulatory response against HBV infection, a number of SNPs located in IL2, IL4, IL6, IL10, IL12B, IL16, IL17, IL18, IL21, IL23R, IFNγ, and TNF‐α genes have been investigated in order to evaluate their importance on the balance between host immunity and viral survival strategies [Wang et al, , ; Gao et al, ; Lu et al, ; Romani et al, ; Tunçbilek, ; Xiang et al, ; Zhang et al, ; Ferreira et al, ; Ren et al, ; Sghaier et al, ; Wu et al, ; Yao et al, ].…”

Association of TNF-α-308(G/A) and -238(G/A) polymorphisms with non-traumatic osteonecrosis of the femoral head risks: a meta-analysis

“…Therefore, we carried out this meta-analysis to reveal the association between TNF-α gene-308 or -238 polymorphisms and NONFH susceptibility. Previous studies revealed that the TNF-α gene-308 polymorphism could be related to TNF-α gene regulation and associated with increased transcriptional activity of its product [32,42,43]. In our meta-analysis, overall samples revealed significant associations between TNF-α gene-308(G/A) polymorphism and NONFH susceptibility in alleles mode (G versus A) and recessive mode (GG versus GA/AA) ( Table 3 and Fig.…”

“…Samara et al reported a G-to-A change at position 238 resulted in an up-regulation of TNF-α gene expression and suggested that the increase of TNF-α expression could lead to osteoclasts proliferation, which contributed to NONFH [32]. On the contrary, another study recently showed that the A-238 allele at position 238 may be associated with downregulation of tissue inflammation [43]. We conducted a meta-analysis including three eligible case-control studies containing 275 cases comparing 610 The total sample demonstrated that statistical significance existed in both of the two models.…”