The relationship between total urinary testosterone and renal calculi

Aswegen, C. H. Van; Hürter, P; Merwe, C. A. Van Der; Plessis, Du

doi:10.1007/bf00256248

Cited by 26 publications

(12 citation statements)

References 9 publications

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“…Ando et al showed that insulin resistance was higher in stone formers of Japanese descent [7]. On the other hand, van Aswegen et al showed that persons with urinary stones have lower testosterone levels compared to healthy persons [8]. Fan et al experimentally showed that testosterone increased the urinary oxalate excretion and kidney calcium oxalate crystal deposition [9].…”

Section: Introductionmentioning

confidence: 99%

The relationship between insulin, insulin resistance, parathyroid hormone, cortisol, testosterone, and thyroid function tests in the presence of nephrolithiasis: a comprehensive analysis

Afsar

Karaca

2014

CEJU

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IntroductionPrevious studies have shown that hormonal factors such as levels of insulin, cortisol, testosterone, and insulin resistance are related with increased nephrolithiasis (NL). However, no previous study has evaluated the relationship between insulin, insulin resistance, thyroid hormones, cortisol, intact parathyroid hormone and testosterone levels with the presence of NL in a comprehensive manner.Materials and methodsAll patients underwent the following procedures: history taking, physical examination, biochemical analysis [including measurement of levels of insulin, thyroid hormones, cortisol, and total testosterone (for male patients only)], urine analysis, 24–hour urine collection to measure urinary protein, sodium excretion, and creatinine clearance. Insulin resistance was evaluated by the homeostasis model assessment index (HOMA–INDEX). The presence of NL was determined by ultrasonography.ResultsThe study was composed of 136 patients. In total, 30 patients had NL. Patients with NL were more likely to be older, male, obese, and smokers. Uric acid and HOMA–INDEX were also higher in patients with NL. In the whole group, only insulin (Odds ratio:1.128, CI:1.029–1.236, P:0.01) but not other hormones, and HOMA–INDEX were related with the presence of NL. In males, none of the hormones including total testosterone were associated with NL.ConclusionsOnly levels of insulin, but not other hormones were associated with the presence of NL in a group of patients with suspicion of NL. More studies are needed to highlight the mechanisms regarding NL and hormone levels.

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Section: Introductionmentioning

confidence: 99%

The relationship between insulin, insulin resistance, parathyroid hormone, cortisol, testosterone, and thyroid function tests in the presence of nephrolithiasis: a comprehensive analysis

Afsar

Karaca

2014

CEJU

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“…[1][2][3][4][5][6][7] These studies have proposed various theories regarding the role of androgens in stone formation. In one of these theories, Yoshioka et al 4 showed that sex hormones in a rat model increased endogenous oxalate synthesis by affecting two major hepatic peroxisomal enzymes, and that testosterone increased crystal deposition by causing oxidative stress injury.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] These studies have sought to explain the mechanism by which androgens lead to stone formation in terms of increasing endogenous oxalate synthesis, suppressing expression of osteopontin from the kidneys, reducing citrate excretion in urine, and leading to oxidative cell damage. [2][3][4][5][6][7] Androgenetic alopecia (AGA), otherwise known as male pattern baldness, is a disorder characterized by follicular miniaturization resulting from increased sensitivity at the follicular level to dihydrotestosterone, a metabolite of testosterone. 8,9 Patients typically present with progressive hair thinning in the area affected, followed by hair loss.…”

Section: Introductionmentioning

confidence: 99%

The association of urolithiasis and androgenetic alopecia

et al. 2015

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Objectives: The objective of this study is to investigate whether patients with androgenetic alopecia were at risk in terms of urinary system stone disease. Patients and methods: Patients with no baldness (Hamilton-Norwood Scala [HNS] stage I) were categorized as Group I, those with hair loss in the frontal region (HNS stages II, III, IIIa, and IVa) as Group II, those with hair loss in the vertex region (HNS stage III-vertex, V) as Group III and those with hair loss in both vertex and frontal regions (HNS stages IV, Va, VI, and VII) as Group IV. Patients in all groups were compared in terms of presence of stone, and the presence of any association between alopecia and urolithiasis, with common etiological risk factors, was investigated. Results: Three hundred and two male patients were included in the study. The presence of urolithiasis was detected in 28.9% of patients in Group I; 26.5% of Group II; 36.9% of Group III; and 44.4% of Group IV (p ¼ 0.085). Among patients aged under 60, urinary stone disease was detected in 30.8% of patients in Group I; 26.4% of Group II; 41.2% of Group III; and 53.8% of Group IV (p ¼ 0.001). In patients aged over 60, urolithiasis was detected in 12.5% of patients in Group I; 26.9% of Group II; 32.2% of Group III; and 37.8% of Group IV (p ¼ 0.371). Conclusions: We determined a significant correlation between vertex pattern and total alopecia with urolithiasis in patients younger than 60 years old.

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“…The total urinary testosterone concentration was lower among stone patients than among normal healthy subjects, suggesting that androgen may play a role in the pathogenesis of urolithiasis [1]. Because the activity of androgen is correlated with the AR, the AR may have a role in stone formation.…”

Section: Discussionmentioning

confidence: 99%

The association of androgen‐ and oestrogen‐receptor gene polymorphisms with urolithiasis in men

Chen

Wu²,

Lin³

et al. 2001

BJU International

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Objective To evaluate the association of urolithiasis with polymorphic microsatellite (encoding cytosine, adenine, and guanine, CAG) repeats in the exon 1 region of the androgen receptor (AR) gene and thymine/adenine (TA) repeats in the oestrogen receptor (ER The results indicate that 21-CAG repeats might be related to a lower risk of stone formation in men (P<0.05). In the ER gene, the peak allelic distribution of TA repeats was 14, showing a significant difference between male stone patients and the normal control subjects (P<0.01). There were no statistical differences between female stone patients and the control subjects in either the AR or the ER gene. Conclusion Urolithiasis among men appears to be associated with AR gene CAG repeat and ER gene TA repeat polymorphisms, whereas there was no significant association among female stone patients. These sex hormone receptors seem to be related to the higher incidence of stone formation among men.

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The relationship between total urinary testosterone and renal calculi

Cited by 26 publications

References 9 publications

The relationship between insulin, insulin resistance, parathyroid hormone, cortisol, testosterone, and thyroid function tests in the presence of nephrolithiasis: a comprehensive analysis

The relationship between insulin, insulin resistance, parathyroid hormone, cortisol, testosterone, and thyroid function tests in the presence of nephrolithiasis: a comprehensive analysis

The association of urolithiasis and androgenetic alopecia

The association of androgen‐ and oestrogen‐receptor gene polymorphisms with urolithiasis in men

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