2023
DOI: 10.3390/ijms25010087
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The Relationship between Trop-2, Chemotherapeutic Drugs, and Chemoresistance

Tomas Koltai,
Larry Fliegel

Abstract: Trop-2 is a highly conserved one-pass transmembrane mammalian glycoprotein that is normally expressed in tissues such as the lung, intestines, and kidney during embryonic development. It is overexpressed in many epithelial cancers but is absent in non-epithelial tumors. Trop-2 is an intracellular calcium signal transducer that participates in the promotion of cell proliferation, migration, invasion, metastasis, and probably stemness. It also has some tumor suppressor effects. The pro-tumoral actions have been … Show more

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