The relationship between two different measures of osteoarthritis bone pathology, bone marrow lesions and 3D bone shape: data from the Osteoarthritis Initiative

Dube, B.; Bowes, M.A.; Hensor, Elizabeth M A; Barr, A.; Kingsbury, Sarah R.; Conaghan, Philip G.

doi:10.1016/j.joca.2018.06.011

Cited by 15 publications

(6 citation statements)

References 12 publications

(29 reference statements)

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“…Bone shape vector, defined as the deviation from normal bone morphology, showed greater responsiveness to change than bone marrow edema lesions. Furthermore, higher bone shape vector for the femur and tibia, indicating greater deviation from normal bone morphology, was associated with the presence of bone marrow edema lesions 48 . Wise et al used statistical shape modeling of knee X-rays to characterize gender-related differences in femur and tibia bone shape in 608 subjects from the OAI.…”

Section: Bone In Knee Oamentioning

confidence: 92%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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PET-MRI". Articles were reviewed to determine relevance based upon the following criteria: 1) study involved human subjects with OA or risk factors for OA and 2) study involved imaging to evaluate OA disease status or OA treatment response. Relevant articles were ranked according to scientific merit, with the best publications selected for inclusion in the narrative report. Results: The PubMed search revealed a total of 1257 articles, of which 256 (20.4%) were considered relevant to OA imaging. Two-hundred twenty-six (87.1%) articles involved the knee joint, while 195 (76.2%) articles involved the use of magnetic resonance imaging (MRI). The proportion of published studies involving the use of MRI was higher than previous years. An increasing number of articles were also published on imaging of subjects with joint injury and on deep learning application in OA imaging. Conclusion: MRI and other imaging modalities continue to play an important role in research studies designed to better understand the pathogenesis, progression, and treatment of OA.

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Section: Bone In Knee Oamentioning

confidence: 92%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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“…BMLs have been associated with pain in OA [ 25 ]. BMLs are also positively correlated to bone shape changes, and bone shape change has shown a higher correlation with OA progression than BMLs [ 30 , 31 ]. Unlike BMLs, which are not seen in every case of OA, we believe that shape changes occur in all cases of OA, and OA patients with abnormal bone shape can be regarded as a special high-risk group.…”

Section: Discussionmentioning

confidence: 99%

Novel nomogram for predicting the progression of osteoarthritis based on 3D-MRI bone shape: data from the FNIH OA biomarkers consortium

Sun

Deng

Zhang

et al. 2021

BMC Musculoskelet Disord

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Background Osteoarthritis(OA) is a major source of pain, disability, and socioeconomic cost in worldwide. However, there is no effective means for the early diagnosis of OA, nor can it accurately predict the progress of OA. To develop and validate a novel nomogram to predict the radiographic progression of mild to moderate OA based on three-dimensional(3D)-MRI bone shape and bone shape change during 24 months. Method Analysis of publicly available data from the Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium. Radiographic progression was defined as minimum radiographic narrowing of the medial tibiofemoral joint space of ≥ 0.7 mm from baseline at 24, 36, or 48 months. There were 297 knees with radiographic progression and 303 without. The bone shapes of the tibia, femur, and patella were evaluated by 3D-MRI at the baseline and at 24 months. Two nomograms were separately established by multivariate logistic regression analysis using clinical risk factors, bone shape at baseline (nomogram 0), or bone shape change at 24 months (nomogram Δ24). The discrimination, calibration, and usefulness were selected to evaluate the nomograms. Results There were significant differences between groups in baseline Kellgren-Lawrence (KL) grade, gender, age, and tibia, femur, and patella shape. The areas under the curve (AUC) of nomogram 0 and nomogram Δ24 were 0.66 and 0.75 (p < 0.05), with accuracy of 0.62 and 0.69, respectively. Both nomograms had good calibration. The decision curve analysis ( DCA) showed that nomogram Δ24 had greater clinical usefulness than nomogram 0 when the risk threshold ranged from 0.04 to 0.86. Conclusions Nomograms based on 3D-MRI bone shape change were useful for predicting the radiographic progression of mild to moderate OA.

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“…With the development of MR sequences and semi-and automatic quantitative determinations of knee tissues, it has become possible to quantify not only the cartilage volume, its loss, average thickness, and morphology [97,98], but also the alteration of the menisci, ligament, infrapatellar fat pad, bone curvature/shape, bone marrow lesions (BMLs), and joint effusion/swelling [99][100][101][102][103][104][105]. All these joint tissues have been found to be involved in the OA pathological process.…”

Section: Imaging Markersmentioning

confidence: 99%

Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review

et al. 2021

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Knee osteoarthritis (OA) is the most common joint disease of the world population. Although considered a disease of old age, OA also affects young individuals and, more specifically among them, those practicing knee-joint-loading sports. Predicting OA at an early stage is crucial but remains a challenge. Biomarkers that can predict early OA development will help in the design of specific therapeutic strategies for individuals and, for athletes, to avoid adverse outcomes due to exercising/training regimens. This review summarizes and compares the current knowledge of fluid and magnetic resonance imaging (MRI) biomarkers common to early knee OA and exercise/training in athletes. A variety of fluid biochemical markers have been proposed to detect knee OA at an early stage; however, few have shown similar behavior between the two studied groups. Moreover, in endurance athletes, they are often contingent on the sport involved. MRI has also demonstrated its ability for early detection of joint structural alterations in both groups. It is currently suggested that for optimal forecasting of early knee structural alterations, both fluid and MRI biomarkers should be analyzed as a panel and/or combined, rather than individually.

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The relationship between two different measures of osteoarthritis bone pathology, bone marrow lesions and 3D bone shape: data from the Osteoarthritis Initiative

Cited by 15 publications

References 12 publications

Osteoarthritis year in review 2019: imaging

Osteoarthritis year in review 2019: imaging

Novel nomogram for predicting the progression of osteoarthritis based on 3D-MRI bone shape: data from the FNIH OA biomarkers consortium

Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review

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