The relationship between upstroke velocity and conduction in guinea pig myocardium

Buchanan, John R.; Saito, Tomoaki; Kagiyama, Yutaka; Hill, Jeffrey L.; Gettes, Leonard S.

doi:10.1016/0002-9149(82)92338-4

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This change in voltage occurs when potassium is increased from 5.4 to approximately 8 mEq/liter. Moreover, the change in conduction varies as the square root of the change in Vmax provided that no other factors important in determining conduction are altered (9). Thus, a 25% slowing of conduction requires a change in Vmax that approaches 50%.…”

Section: Electrocardiographic Waveformmentioning

confidence: 99%

Perspectives and future trends in cellular electrophysiology: Implications for the clinician

Gettes

1983

Journal of the American College of Cardiology

Self Cite

View full text Add to dashboard Cite

As a result of single fiber electrophysiologic studies, the clinical approach to the electrical behavior of the heart has improved. Three areas are examined: 1) the electrocardiographic waveform, 2) normal and abnormal cardiac rhythms, and 3) the mechanism of action of antiarrhythmic drugs. In each area, the results of single fiber studies have provided a conceptual framework for diagnostic and therapeutic decisions. These studies have also enabled investigators to test hypotheses formulated from clinical observations. It may be only a slight exaggeration to attribute many of our recent advances in each of the three areas to the development and use of the microelectrode.

show abstract

Section: Electrocardiographic Waveformmentioning

confidence: 99%

Perspectives and future trends in cellular electrophysiology: Implications for the clinician

Gettes

1983

Journal of the American College of Cardiology

Self Cite

View full text Add to dashboard Cite

show abstract

The effects of antiarrhythmic drugs, stimulation frequency, and potassium-induced resting membrane potential changes on conduction velocity and dV/dtmax in guinea pig myocardium.

Buchanan¹,

Saito²,

Gettes³

1985

Circulation Research

148

View full text Add to dashboard Cite

For one-dimensional propagation, a nonlinear relationship between Vmax and conduction velocity is predicted by cable theory, and, under experimental conditions, Vmax and conduction velocity may change in opposite directions. Using standard microelectrode techniques, we have measured Vmax and conduction velocity in guinea pig papillary muscles exposed to tetrodotoxin and low sodium (agents expected primarily to decrease, directly, the rapid inward current), increased extracellular potassium (an agent which decreases the rapid inward current at least partially by inactivation mediated by depolarization of the resting membrane potential), and, over a wide range of stimulation frequencies, the antiarrhythmic drugs, quinidine, lidocaine, and procainamide. In all cases, except for the region of potassium-induced "supernormal conduction" between 5.4 and 9 mM, Vmax and conduction velocity varied as predicted by one-dimensional cable theory; that is, changes in Vmax were always proportional to changes in the square of conduction velocity. We conclude that the relationship between Vmax and conduction velocity predicted by cable theory occurs experimentally in guinea pig papillary muscle subjected to commonly used antiarrhythmic drugs and other interventions expected to reduce the sodium inward current. This relationship may be useful in applying known effects of drugs on Vmax to action potential propagation.

show abstract

The relationship between upstroke velocity and conduction in guinea pig myocardium

Cited by 2 publications

References 0 publications

Perspectives and future trends in cellular electrophysiology: Implications for the clinician

Perspectives and future trends in cellular electrophysiology: Implications for the clinician

The effects of antiarrhythmic drugs, stimulation frequency, and potassium-induced resting membrane potential changes on conduction velocity and dV/dtmax in guinea pig myocardium.

Contact Info

Product

Resources

About