The relationship between vitamin A status and oxidative stress in animal production

Shastak, Yauheni; Gordillo, Álvaro; Pelletier, Wolf

doi:10.1080/09712119.2023.2239319

Cited by 15 publications

(18 citation statements)

References 71 publications

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“…So, retinoic acid upon lysine/hydroxylase functions activate both Phe / hydroxylase and E coli that activate the Estrogen expression mediated by ROR-beta production regulated by synthase function followed by activating dopamine and all of B-adrenergic, oxytocin gene, and Nrf2 expression via activating NR4As productive pathway which it's important pathway for activating and adopting heart functions, where the activation of previous NR4As pathway by retinoic acid explain why RA has the role of antioxidant functions. That, other studies indicated that: Vitamin A possesses antioxidant properties by directly scavenging reactive oxygen species, boosting antioxidant enzyme activity, antioxidant defence mechanisms [131]. So, Vitamin A or retinol is the most multifunctional vitamin in the human enhance the ROR-beta and estrogen synthesis by synthase function followed by activating NR4As pathway which activate oxitocin and Nrf2 productive functions which are important for activating both of heme oxygenase and antiinflammatory processes mediated by Ang2-AT2 and VEGF-A productive functions.…”

Section: Retinoic Acid Adopt Myocardial Function By Modifying Mitocho...mentioning

confidence: 96%

Decreasing in Lysine Reflect Lysosomal Dysfunction and Accumulated Phenylalanine which Connected to WMH and CVD and Both of Phenylketonuria and Calcifications where N-Acetylcysteine Prevent Organs Failure

M El Tantawi

2024

J Cardiol Res Rev Rep

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Phenylalanine function stabilized by lysine which found on lysosomal surface, that Phe necessary to regulate the synthesis or secretion of α-amylase, trypsin and lipase, where the Severe acute pancreatitis in a child with phenylketonuria. The phenylketonuria due to decreased lysine followed by lysosomal dysfunction that will be result of deficiency in phenylalanine function that will not form pancreatic enzymes and stomach enzyme and will be accumulated. The Lysosomal dysfunction will be result of accumulation of undigested polymer including inflammation which play important roles in pathophysiology, that reflect reduction in lysine acylation followed by reduction in aminoacyl tRNAs which promote Phe and E coli functions for activating protein and mRNAs synthesis, that will be followed by increasing in TNf-a synthesis (and reduction in VEGF-As ) which activate NK (not beings related to human immune proper function ) which regulated by the undigested polymers in random pathways stimulated by TNf-a functional pathway (activated by NLRP3 inflammasome. Retinoic acid is necessary to promote lysine acylation which regulate aminoacyl-tRNAs production regulated by mitochondrial enzymes, which regulate mRNA production by E coli (regulated by phenylalanine) that necessary to run antioxidant functions and cellular biosynthesis. Lysine acetylation so important to regulates the activity of Escherichia coli Sadenosylmethionine synthase. RNA (produced by E coli) is 2′-O-methylated demonstrated higher stability that can improve immune by promoting anti-inflammatory processes and improve myocardial functions, and adopt heart constriction by activating NR4As pathway. The antihypertensive pathway mechanism is: the Lysine ¬¬>activate ATPase (stimulate retinoic acid “RA” ) ¬¬>Lysine acetylation ¬¬> promote Phe/ hydroxylase ¬¬> followed by ¬>activate Tyr/ hydroxylase ¬>activate dopamine ¬> activate NR4As pathway ¬>GC-beta ¬>activate both of Oxytocin and Nrf2 ¬> Ang2-AT2 and VEGF-A productive functions ¬>heme oxygenase ¬>anti-inflammatory growth and processes. Lysine Methylation has important role in adopt hypertension through activating pervious Antihypertensive pathway mediated by Phe hydroxylase synthesis and Tyr hydroxylase production followed by activating both of dopamine and NR4As pathway. The oxidation of phenylalanyl-tRNA synthetase positively regulates translational quality control, and regulates the initiation of digestive enzyme mRNA translation, where consecutive AAA-lysines is paused for encoding Phe followed by ribosome sliding on homopolymeric A sequence. That lysine activates mitochondria function followed by promoting Phenylalanine and phenylalanine-tRNAs productions by translations within E coli, followed by Phe/ hydroxylase activate Tyr hydroxylase production which activate dopamine synthesis. And positively, Lysine is the most effective amino acid for activating all of ATPase, GTPase, and lysosomes, and E coli functions, where ATPase necessary for activating lysine Phosphorylation for activating lysosome digestion, followed by activating E coli through activating Phe hydroxylase production, while GTPase necessary for activating mitochondrial repairs, which act on pro-inflammation and cholesterol for activating estrogen production and activating the NR4As pathway which activate all of Oxytocin, Nrf2 followed by Ang2-AT2 and VEGF-A production and then followed by activating heme oxygenase and anti-inflammatory growth and processes that prevent LV-hypertrophy, and prevent coronary calcification.

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Section: Retinoic Acid Adopt Myocardial Function By Modifying Mitocho...mentioning

confidence: 96%

Decreasing in Lysine Reflect Lysosomal Dysfunction and Accumulated Phenylalanine which Connected to WMH and CVD and Both of Phenylketonuria and Calcifications where N-Acetylcysteine Prevent Organs Failure

M El Tantawi

2024

J Cardiol Res Rev Rep

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“…Oxidative damage to DNA, proteins, and lipids is widely recognized as a significant factor contributing to aging and the development of various chronic diseases in cats and dogs [145]. Vitamin A plays a vital role as a systemic antioxidant, impacting various biological processes in animals, including pets [4,146]. Retinol possesses direct antioxidant properties due to its hydrophobic polyene chains, allowing it to quench singlet oxygen and neutralize radicals [147].…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

“…Vitamin A and vitamin E are both powerful antioxidants that protect cells from oxidative damage and play essential roles in maintaining skin health, vision, and the immune function [4,192]. While they have distinct antioxidant properties, they may also interact synergistically to enhance each other's effectiveness.…”

Section: Vitamin a And Vitamin Ementioning

confidence: 99%

“…In the important domain of companion animal health, particularly concerning species such as dogs and cats, there is an increasing emphasis on the vital role of nutrition, particularly in relation to vitamins. Veterinarians, pet owners, and researchers are progressively acknowledging the significance of these organic compounds in animal well-being and longevity, given their indispensable role in physiological functions [1][2][3][4]. Vitamins, functioning as crucial components in the complex machinery of life, serve diverse roles, with vitamin A being notably versatile, involved in vision, immune system modulation, cellular differentiation, and reproduction [5].…”

Section: Introductionmentioning

confidence: 99%

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Pet Wellness and Vitamin A: A Narrative Overview

Shastak,

Pelletier

2024

Animals

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The health of companion animals, particularly dogs and cats, is significantly influenced by nutrition, with vitamins playing a crucial role. Vitamin A, in particular, is indispensable, with diverse roles ranging from vision to immune modulation and reproduction. Despite its importance, the metabolism and dietary requirements of vitamin A in companion animals remain complex and not fully understood. This review provides a comprehensive overview of the historical perspective, the digestion, the metabolism, the physiological roles, the deficiency, the excess, and the interactions with other micronutrients of vitamin A in companion animals. Additionally, it highlights future research directions and gaps in our understanding. Insights into the metabolism of vitamin A in companion animals, personalized nutrition strategies based on genetic variability, longitudinal studies tracking the status of vitamin A, and investigations into its immunomodulatory effects are crucial for optimizing pet health and wellness. Furthermore, understanding the stability and bioavailability of vitamin A in pet food formulations is essential for ensuring the provision of adequate micronutrients. Overall, this review underscores the importance of vitamin A in companion animal nutrition and the need for further research to enhance our understanding and to optimize dietary recommendations for pet health and well-being.

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“…Hypovitaminosis A leads to distortion of early offspring development, vision impairment, compromised cellular immune responses, and diminished antibody synthesis ( 2 ). This condition also induces heightened oxidative stress levels, further impacting the growth and overall well-being of animals ( 3 ). While mammals, including dogs, possess the inherent capability to convert precursor compounds, such as dietary carotenoids (e.g., β-carotene), into vitamin A, their effective capacity for such synthesis can be influenced by various factors.…”

Section: Introductionmentioning

confidence: 99%

Stability of vitamin A at critical points in pet-feed manufacturing and during premix storage

Galli,

Andretta,

Martinez

et al. 2024

Front. Vet. Sci.

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The objective of this research was to assess and quantify the potential vitamin A losses that occur during the manufacturing of pet feed and premix, as well as during their extended storage periods. This trial was conducted at a commercial feeder mill that utilized a standard commercial dog feed along with a corresponding vitamin-mineral premix. The calculated amount of vitamin A supplemented in the feed, in addition to the endogenous vitamins present in the ingredients, was adjusted to 18,000 IU/kg of feed. Five 500 g feed samples were collected at each of the predefined critical points throughout the manufacturing process (after mixing, milling, preconditioner, and extrusion/drying processes) to verify the stability of vitamin A during feed production. Additionally, various samples were collected at regular intervals of 30, 60, 90, 120, and 180 days during the storage of the premix to assess the stability of vitamin A. Vitamin A analyses in the samples were performed using high-performance liquid chromatography. The variables were assessed for normality using the Shapiro–Wilk test, followed by analysis of variance (ANOVA) and Tukey’s test to compare the differences between the manufacturing process and premix shelf life. The statistical significance was set at 95%. The vitamin losses during the pre-conditioning process were 26%, and during the extrusion-drying processes, the losses were 34% when compared to the initial analyzed value. However, no differences were observed in other processes. There were no significant differences observed in recovered vitamin levels in the premix during its shelf-life (p = 0.484). The study indicated that the primary vitamin A losses in pet feed manufacturing processes occur during the pre-conditioning and drying/extrusion steps. However, it is worth noting that no significant losses of vitamin A were found during the premix storage phase.

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The relationship between vitamin A status and oxidative stress in animal production

Cited by 15 publications

References 71 publications

Decreasing in Lysine Reflect Lysosomal Dysfunction and Accumulated Phenylalanine which Connected to WMH and CVD and Both of Phenylketonuria and Calcifications where N-Acetylcysteine Prevent Organs Failure

Decreasing in Lysine Reflect Lysosomal Dysfunction and Accumulated Phenylalanine which Connected to WMH and CVD and Both of Phenylketonuria and Calcifications where N-Acetylcysteine Prevent Organs Failure

Pet Wellness and Vitamin A: A Narrative Overview

Stability of vitamin A at critical points in pet-feed manufacturing and during premix storage

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