The Relationship Between Vitamin D and Activity of Daily Living in the Elderly

Li, Han; Han, Demin; Wang, Haiyan; Shu, Dan; Xu, Lei; Hou, Liufang; Xu, Ying; Lai, Xueli

doi:10.2147/ijgm.s366203

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…30 A lower BI is associated with readmission, 31 disability, socioeconomic loss, 32 and mortality. 31,33 Previous studies used a BI score ⩽40 as a cut-off point for the ability to perform ADL; [34][35][36][37] we also adopted this cutoff. In one study, the rates of death and staying at long-term care facilities at 6 months after discharge were higher in patients with a BI ⩽40 at discharge.…”

Section: Discussionmentioning

confidence: 99%

Predictors of poor clinical outcomes including in-hospital death and low ability to perform activities of daily living at discharge in hospitalized patients with chronic obstructive pulmonary disease exacerbation

Murakami

Yasui

Sato

et al. 2023

Ther Adv Respir Dis

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Background: Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and morbidity worldwide. Many patients with COPD experience exacerbations that require hospitalization, which is associated with an increased risk of in-hospital death and impaired ability to perform activities of daily living (ADL). Declining ability to perform ADL is a critical issue for these patients. Objectives: To identify predictors of poor clinical outcomes, including in-hospital death and low ability to perform ADL at discharge, in patients who are hospitalized with exacerbation of COPD. Design: This retrospective study involved a cohort of patients with exacerbation of COPD who were admitted to Iwata City Hospital in Japan between July 2015 and October 2019. Methods: We collected clinical data, measured the cross-sectional area of the erector spinae muscles (ESMCSA) on computed tomography (CT) scans at admission, and investigated the associations of poor clinical outcomes (in-hospital death and severe dependence when performing ADL, defined as a Barthel Index (BI) of ⩽40 at discharge) with clinical parameters. Results: Overall, 207 patients were hospitalized for exacerbation of COPD during the study period. The incidence of poor clinical outcomes was 21.3%, and the in-hospital mortality rate was 6.3%. Multivariate logistic regression analyses showed that older age, long-term oxygen therapy, an elevated D-dimer concentration, and a reduced ESMCSA on chest CT at admission were significantly associated with poor clinical outcomes (in-hospital death and a BI of ⩽40). Conclusion: Hospitalization for exacerbation of COPD was associated with high rates of in-hospital mortality and a BI of ⩽40 at discharge, which may be predicted by assessment of ESMCSA.

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Section: Discussionmentioning

confidence: 99%

Predictors of poor clinical outcomes including in-hospital death and low ability to perform activities of daily living at discharge in hospitalized patients with chronic obstructive pulmonary disease exacerbation

Murakami

Yasui

Sato

et al. 2023

Ther Adv Respir Dis

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“…In total, 185 participants aged over 40 years without dementia underwent complete 3T MRI sequences necessary for evaluating WMH volume and OCT examination necessary for evaluating retinal thickness. Exclusion criteria were as follows: (1) neurological diseases, such as acute and large-area stroke, tumor, epilepsy, mental disorders, central nervous system demyelinating disease, or trauma; (2) any cognitive deterioration history or ever had a diagnosis of dementia; (3) Barthel Activities of Daily Living Index [scale 0–100, 10 items including feeding, personal toileting, bathing, dressing and undressing, getting on and off a toilet, controlling bladder, controlling bowel, moving from wheelchair to bed and returning, walking on level surface (or propelling a wheelchair if unable to walk), and ascending and descending stairs] < 80 ( 36 ); (4) contraindications to MRI; (5) primary eye diseases, such as severe diabetic and hypertensive retinopathy, cataract, glaucoma, macular degeneration, intraocular pressure > 21 mmHg, high myopia, or prior ocular surgery; and (6) other hematological and metabolic diseases.…”

Section: Methodsmentioning

confidence: 99%

Retinal thickness changes in different subfields reflect the volume change of cerebral white matter hyperintensity

Teng²,

Jia³

et al. 2022

Front. Neurol.

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PurposeTo investigate the relationship between the retinal thickness in different subfields and the volume of white matter hyperintensity (WMH), with the hope to provide new evidence for the potential association between the retina and the brain.MethodsA total of 185 participants aged over 40 years were included in our study. Magnetic resonance imaging (MRI) was used to image the WMH, and WMH volume was quantitatively measured by a specific toolbox. The thickness of the total retina, the retinal nerve fiber layer (RNFL), and the ganglion cell and inner plexiform layer (GCIP) was measured by optical coherence tomography (OCT) in nine subfields. The association between retinal thickness and WMH volume was demonstrated using binary logistic regression and Pearson correlation analysis.ResultsParticipants were divided into two groups by the WMH volume (‰, standardized WMH volume) median. In the quartile-stratified binary logistic regression analysis, we found that the risk of higher WMH volume showed a positive linear trend correlation with the thickness of total retina (95% CI: 0.848 to 7.034; P for trend = 0.044)/ GCIP (95% CI: 1.263 to 10.549; P for trend = 0.038) at the central fovea, and a negative linear trend correlation with the thickness of nasal inner RNFL (95% CI: 0.086 to 0.787; P for trend = 0.012), nasal outer RNFL (95% CI: 0.058 to 0.561; P for trend = 0.004), and inferior outer RNFL (95% CI: 0.081 to 0.667; P for trend = 0.004), after adjusting for possible confounders. Correlation analysis results showed that WMH volume had a significant negative correlation with superior outer RNFL thickness (r = −0.171, P = 0.02) and nasal outer RNFL thickness (r = −0.208, P = 0.004).ConclusionIt is suggested that central fovea and outer retina thickness are respectively associated with WMH volume. OCT may be a biological marker for early detection and longitudinal monitoring of WMH.

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Association Between Dysmobility Syndrome with Serum Vitamin D in Community-Dwelling Older Adults

Kong,

Lee

2023

Exerc Sci

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PURPOSE: To investigate the association between serum vitamin D levels and dysmobility syndrome (DMS) in community-dwelling older adults.METHODS: This cross-sectional study included 390 older adults (80.7% female) with a mean (±SD) age of 74.8±5.5 years. Based on high body fat level, osteoporosis, low muscle mass, slow gait speed, low grip strength, and fall(s), participants were classified as robust, pre-DMS, or DMS. Based on serum vitamin D levels, subjects were classified as high 33%, middle 33%, and lower 33%, and/or ≥20 ng/mL and <20 ng/mL, respectively. Logistic regression analyses were performed to determine odds ratios (OR) for serum vitamin D levels in DMS.RESULTS: There were linear increases in DMS variables such as high body fat (p = .040), slow gait speed (p = .048), fall(s) (p = .005), and prevalence of DMS (p = .001) across decremental serum vitamin D levels. Compared with the high vitamin D group (as reference), the low 33% group exhibited a higher OR for DMS (OR 2.776, p = .02). Similarly, compared with the vitamin D ≥20 ng/mL group (as reference), the <20 ng/mL group had a higher OR for DMS (OR 2.486, p = .002).CONCLUSIONS: Findings of this study suggest higher serum vitamin D levels through promoting outdoor physical activity and a healthy diet are key components protecting older adults against DMS.

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The Relationship Between Vitamin D and Activity of Daily Living in the Elderly

Cited by 3 publications

References 34 publications

Predictors of poor clinical outcomes including in-hospital death and low ability to perform activities of daily living at discharge in hospitalized patients with chronic obstructive pulmonary disease exacerbation

Predictors of poor clinical outcomes including in-hospital death and low ability to perform activities of daily living at discharge in hospitalized patients with chronic obstructive pulmonary disease exacerbation

Retinal thickness changes in different subfields reflect the volume change of cerebral white matter hyperintensity

Association Between Dysmobility Syndrome with Serum Vitamin D in Community-Dwelling Older Adults

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