The relationship between vitamin D deficiency, body composition, and physical/cognitive functions

Doğan, Yahya; Kara, Murat; Culha, Mehmet Ali; Özçakar, Levent; Kaymak, Bayram

doi:10.1007/s11657-022-01109-6

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…In this regard, Wen et al (2018) showed vitamin D deficiency in pregnant mice results in the proliferation and differentiation of pre‐adipocytes, alterations of gene methylation, and obesity in offspring. Furthermore, Doğan et al (2022) demonstrated that vitamin D deficiency is related to BMI, and independently increased body visceral fat (Doğan et al, 2022). Although we did not evaluate the visceral fat of the whole body in this study, the results show that the visceral fat of the right and left epididymis increased non‐significantly in the vitamin D deficiency group compared with the other two groups.…”

Section: Discussionmentioning

confidence: 99%

Overlapping sperm damages from vitamin B or D deficiency in mice: Insights into the role of clinical supplementations

et al. 2022

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In this study, the effect of 14 weeks of standard diet (controls) or folate and vitamin B12-free diet (VBD group) or vitamin D-free diet (VDD group) were assessed on mice testicular function, and sperm function. Vitamin D deprivation caused increased body weight with no effect from VBD confirming the calcium-independent role of vitamin D on body weight homeostasis. The two deprivations caused convergent damages including decreased testosterone, worsened Johnson scores, tubular differentiation index and spermatogenesis index, and serious worsening of sperm parameters and of sperm functional tests (DNA methylation, protamination, DNA damage and lipid peroxidation). From a metabolic point of view, the damage from both models converged on the one carbon cycle (methylations) and the transsulfuration pathway (GSH and antioxidant defences) and increased circulating homocysteine, although with different mechanisms: VBD appeared to hamper methylations due to lower ability to regenerate homocysteine to methionine whereas VDD appeared to interfere with homocysteine transsulfuration to cysteine and, thereafter, GSH. VDD also caused a huge paradox increase of vitamin B12, which was likely in a non-functional form and warrants further investigation. These findings strongly endorse the potential benefit of combined folate/B12 and vitamin D supplementation in infertile patients.

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Section: Discussionmentioning

confidence: 99%

Overlapping sperm damages from vitamin B or D deficiency in mice: Insights into the role of clinical supplementations

et al. 2022

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“…In the present study, the inhibitor significantly reduced obesity in MRL/LPR mice. Other studies 17,18 have revealed a correlation between VitD deficiency and tissue fat thickness. That supplementation with VitD3 can reduce weight gain and fat accumulation in mice has confirmed, and the study showed that the body weight of C57BL/6 mice on a high‐fat diet changed significantly after continuous supplementation with VitD3 for 10 weeks 19,20 .…”

Section: Discussionmentioning

confidence: 90%

Vitamin D improves autoimmune diseases by inhibiting Wnt signaling pathway

Zou,

Song,

Yin

et al. 2024

Immunity Inflam & Disease

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ObjectiveIn this study, we investigated the development of the Wnt signaling pathway in vitamin D (VitD) to improve systemic lupus erythematosus in mice to breakthrough clinical treatment approaches.MethodsBody weight changes were recorded during rearing. Antinuclear antibodies (ANA), anti‐dsDNA, and anti‐snRNP were detected in the mouse serum using an enzyme‐linked immunosorbent assay. Apoptosis of Th1 and Th2 immune cells in mice was detected using flow cytometry. Reverse transcription polymerase chain reaction was used to detect the expression of T‐bet, GATA3, and Wnt3a mRNA in the spleens of each group. Western blot analysis was performed to detect the expression of Wnt1, p‐β‐catenin, β‐catenin, glycogen synthase kinsase3β (GSK‐3β), Wnt3a, c‐myc, and cyclin D1 protein in mice spleens. β‐catenin in mice spleen was visualized using immunohistochemistry.ResultsVitD did not substantial reduce the body weight of MRL/LPR mice, whereas the inhibitor did. VitD notably decreased the concentrations of ANA, anti‐double‐stranded DNA, and anti‐snRNP in the serum of MRL/LPR mice and alleviated apoptosis of Th1 and Th2 cells. VitD markedly increased the expression of T‐bet and GATA mRNA in the spleen of MRL/LPR mice and consequently increased the levels of Wnt3a and β‐catenin. Western blot analysis revealed that the levels of GSK‐3β, p‐β‐catenin, Wnt1, Wnt3a, c‐myc, and cyclin D1 could be reduced by VitD, compared with MRL/LPR. Immunohistochemistry demonstrated that the expression of β‐catenin was the most pronounced in the spleen of MRL/LPR mice, and the expression level of β‐catenin decreased substantially after VitD intervention.ConclusionsVitD can further inhibit the nuclear translocation of β‐catenin by downregulating the expression of Wnt ligands (Wnt1 and Wnt3a), which reduces the expression of the downstream target gene cyclin D1. Systemic lupus erythematosus in mice was improved by inhibiting the activation of Wnt/β‐catenin signal pathway.

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“…In addition, the tendency of shift workers to eat meals at irregular times and their tendency to eat a diet rich in fatty and junk food could lead to a reduced dietary intake of vitamin D [ 13 , 14 ]. It is also known that shift workers tend to have a BMI higher than the general population [ 15 , 36 , 37 ], a factor that could lead to the increased sequestration of vitamin D in adipose tissue and, consequently, lower values of circulating vitamin D [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Shift Work and Serum Vitamin D Levels: A Systematic Review and Meta-Analysis

Martelli

Salvio

Santarelli

et al. 2022

IJERPH

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Vitamin D deficiency and insufficiency are highly prevalent conditions worldwide due to several factors, including poor sun exposure. Shift workers may be exposed to the risk of hypovitaminosis D due to fewer opportunities for sunlight exposure compared to day workers. A systematic review of the PubMed, SCOPUS, and EMBASE databases was conducted according to the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) statement to investigate the effect of shift work on vitamin D levels. Mean differences (MD) and 95% confidence intervals (CI) of serum 25-OH-D levels in shift workers and non-shift workers were calculated. A total of 13 cross-sectional studies were included in the meta-analysis. We found significantly lower levels of serum 25-OH-D in shift workers compared with non-shift workers (MD: −1.85, 95% CI [−2.49 to −1.21]). Heterogeneity among included studies was high (I2 = 89%, p < 0.0001), and neither subgroup analysis nor meta-regression were able to identify specific sources of the heterogeneity that may be related to the different characteristics of shift work among studies. The monitoring of serum vitamin D levels and prompt correction of any deficiencies should be considered in shift workers. Notably, since a large part of the observations are derived from Koreans, larger epidemiological studies are needed in other populations.

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The relationship between vitamin D deficiency, body composition, and physical/cognitive functions

Cited by 7 publications

References 36 publications

Overlapping sperm damages from vitamin B or D deficiency in mice: Insights into the role of clinical supplementations

Overlapping sperm damages from vitamin B or D deficiency in mice: Insights into the role of clinical supplementations

Vitamin D improves autoimmune diseases by inhibiting Wnt signaling pathway

Shift Work and Serum Vitamin D Levels: A Systematic Review and Meta-Analysis

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