The relationship between Vitamin D status and exacerbation in COPD patients– a literature review

Ferrari, Renata; Caram, Laura; Tanni, Suzana Erico; Godoy, Irma; Paiva, Sérgio Alberto Rupp de

doi:10.1016/j.rmed.2018.04.012

Cited by 26 publications

(28 citation statements)

References 37 publications

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“…In animal studies, vitamin D deficiency was shown to promote an early lung function decline after cigarette smoke [66], suggesting a role for vitamin D in the development of COPD. The association between vitamin D serum levels and the frequency of exacerbations is, however, still unclear [73]. In the meta-analysis of Zhu et al [74], no clear relationship was reported.…”

Section: Vitamin D In Copd and Exacerbationsmentioning

confidence: 99%

Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

et al. 2019

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Patients with respiratory diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or asthma often experience an acute worsening of respiratory symptoms, termed exacerbations. Although the course of exacerbations is disease specific, they are mostly triggered by a respiratory infection. Exacerbations often require hospitalization and are an important cause of mortality. Treatments of exacerbations aim to minimize the negative impact and to prevent subsequent events. Despite many existing therapy options, many patients do not benefit from therapy and suffer from recurrent events. Vitamin D deficiency is a worldwide problem and is extremely prevalent in these patients. Vitamin D, known for its calcemic effects, also has immunomodulatory and anti-infectious actions and can therefore be a possible agent to treat or prevent exacerbations. This review will focus on vitamin D as a potential candidate to treat or prevent exacerbations in CF, COPD, and asthma.

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Section: Vitamin D In Copd and Exacerbationsmentioning

confidence: 99%

Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

et al. 2019

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“…However, the role of vitamin D in chronic obstructive pulmonary disease (COPD) is less clear. COPD patients have been shown to have an increased rate of vitamin D deficiency [5], but there has not been a consistent relationship between vitamin D levels and risk of respiratory exacerbations [6]. Clinical trials [7][8][9] investigating the effect of vitamin D supplementation on the rate of exacerbations have yielded conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study

et al. 2020

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Background: Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the effect of vitamin D levels on imaging characteristics remains mostly unexplored. Using cross-sectional and longitudinal follow up data from the COPDGene Study, we assessed the association between vitamin D levels on respiratory symptoms, exacerbations, and imaging characteristics. We hypothesized that vitamin D deficiency will be associated with worse respiratory-related outcomes. Methods: Current and former smokers between ages 45-80 were enrolled the COPDGene Study. Subjects completed questionnaires, spirometry, six-minute walk test, and chest computed tomography scans. A subset of subjects had measurement of serum concentration of 25-hydroxyvitamin D (25(OH)D). Vitamin D deficiency was defined as serum concentration less than 20 ng/mL. Longitudinal follow up was conducted via a web-based or telephone questionnaire. Results: Vitamin D levels were measured on 1544 current and former smokers, of which 981 subjects had sufficient vitamin D levels and 563 subjects had vitamin D deficiency. Subjects with vitamin D deficiency were younger with increased likelihood of being African American, being current smokers, having a lower percent predicted FEV 1 , and having COPD. Vitamin D deficiency was associated with worse quality of life, increased dyspnea, decreased exercise tolerance, and increased frequency of severe exacerbations. Vitamin D deficiency was also associated with increased segmental airway wall thickness on chest CT scans. Conclusion: Vitamin D deficiency was associated with increased respiratory symptoms, decreased functional status, increased frequency of severe exacerbations, as well as airway wall thickening on chest CT scans. Further research is needed to determine the potential impact of vitamin D supplementation to improve disease outcomes.

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“…There have been fewer studies done on the role of vitamin D 3 in patients with COPD. Vitamin D 3 may affect quality of life, lung function, and number of exacerbations in patients with COPD 6,7,12. Han et al investigated the effects of vitamin D 3 in rat models of COPD 12.…”

Section: Introductionmentioning

confidence: 99%

<p>Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial</p>

Foumani¹,

Mehrdad²,

Jafarinezhad³

et al. 2019

COPD

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COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D 3 on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin D 3 once a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV 1 , FEV 1 /FVC, and number of exacerbations in patients with COPD ( P >0.05). In the intervention group, a significant difference was observed in quality of life at 2 months ( P <0.001) and 6 months ( P <0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D 3 , as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.

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The relationship between Vitamin D status and exacerbation in COPD patients– a literature review

Cited by 26 publications

References 37 publications

Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

Vitamin D deficiency is associated with respiratory symptoms and airway wall thickening in smokers with and without COPD: a prospective cohort study

<p>Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial</p>

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