The relationship between xerostomia and diabetes mellitus: A little known complication

Aguilera, Cristina; Armas, María Guadalupe Guijarro de; Megías, Susana Monereo; Viveros, María Merino; Ranero, Clara Torán

doi:10.1016/j.endoen.2014.09.008

Cited by 10 publications

(4 citation statements)

References 5 publications

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“…The highest percentage of patients with xerostomia was observed in the group of diabetics with poor glycemic control (83.3%). Numerous studies reported a significantly higher presence of xerostomia in patients with diabetes compared to healthy subjects [20][21][22] . Carda et al observed presence of xerostomia in 76.4% diabetics, while the presence was significantly less (18.7%) in healthy subjects 23 .…”

Section: Discussionmentioning

confidence: 99%

Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2

et al. 2017

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“…Diabetes is often accompanied by dysfunction of salivary glands, which resulting in the development of xerostomia, a condition characterized by decreased saliva secretion [ 175 ]. Submandibular gland dysfunction might be responsible for the heightened vulnerability to oral infections and compromised wound repair in patients with diabetes.…”

Section: Mscs Derived Exosomes and Diabetic Complicationsmentioning

confidence: 99%

Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

Jiao,

Chen,

Tang

et al. 2024

Cell Death Dis

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Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes to this pessimistic situation and negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as the most likely new breakthrough and advancement in treating of diabetes and diabetes‐associated complication due to its capacity of intercellular communication, modulating the local microenvironment, and regulating cellular processes. In the present review, we briefly outlined the properties of MSCs-derived exosomes, provided a thorough summary of their biological functions and potential uses in diabetes and its related complications.

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“…Salivary gland dysfunction in diabetes can cause xerostomia, characterized by a reduced amount of saliva secretion [172]. Xerostomia itself aggravates oral candidiasis infection in patients with diabetes.…”

Section: Salivary Gland Hypofunctionmentioning

confidence: 99%

Diabetes complications and extracellular vesicle therapy

Soltani

Mansouri

Parvaneh

et al. 2021

Rev Endocr Metab Disord

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Diabetes is a chronic disorder characterized by dysregulated glycemic conditions. Diabetic complications include microvascular and macrovascular abnormalities and account for high morbidity and mortality rates in patients. Current clinical approaches for diabetic complications are limited to symptomatic treatments and tight control of blood sugar levels. Extracellular vesicles (EVs) released by somatic and stem cells have recently emerged as a new class of potent cell-free therapeutic delivery packets with a great potential to treat diabetic complications. EVs contain a mixture of bioactive molecules and can affect underlying pathological processes in favor of tissue healing. In addition, EVs have low immunogenicity and high storage capacity while maintaining nearly the same regenerative and immunomodulatory effects compared to current cellbased therapies. Therefore, EVs have received increasing attention for diabetes-related complications in recent years. In this review, we provide an outlook on diabetic complications and summarizes new knowledge and advances in EV applications. Moreover, we highlight recommendations for future EV-related research.

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The relationship between xerostomia and diabetes mellitus: A little known complication

Cited by 10 publications

References 5 publications

Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2

Oral symptoms and mucosal lesions in patients with diabetes mellitus type 2

Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

Diabetes complications and extracellular vesicle therapy

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