The relationship of afterload to ejection performance in chronic mitral regurgitation.

Abstract

Simultaneous left ventricular micromanometry and biplane cineangiography were performed in nine control subjects (group 1), 14 patients with chronic mitral regurgitation and an ejection fraction of 57% or greater (group 2), and 13 patients with mitral regurgitation and an ejection fraction of less than 57% (group 3). End-diastolic volume index was increased in both groups with mitral regurgitation (p < .001) compared with the control group. Left ventricular end-diastolic wall thickness did not differ among the three groups, but the left ventricular muscle mass index was greater in both groups with mitral regurgitation than in controls (p < .001). End-diastolic pressure was elevated in both groups 2 and 3 compared with group 1 (p < .05), but peak systolic, mean systolic, and incisural pressure were not different among the three groups. End-diastolic stress was larger in groups 2 and 3 than in group 1 (p < .05). Muscle fiber stretch was greater in group 2 than in the control group (p < .05) but was not different between the controls and group 3. End-systolic stress, determined as the circumferential stress at aortic valve closure, at the maximal pressure/volume ratio, or using a nonsimultaneous method, was larger in group 3 than in groups 1 and 2. Mean systolic stress was evaluated from aortic valve opening to aortic valve closure in all patients; mean stress from end-diastole to aortic valve closure and from end-diastole to minimum volume was assessed in mitral regurgitation alone. For all three intervals, mean stress determinations were larger in group 3 than the mean stress from aortic valve opening to closure in the controls (p < .05), whereas only the mean stress determined from aortic valve opening to closure was greater in group 2 than in the control group (p < .01). For each of the intervals, the calculated mean stress was larger in group 3 than in group 2 (p < .05). Evaluation of the endsystolic stress-and mean ejection stress-ejection fraction relationships revealed an overlap of control with group 2 data, group 3 values were downwardly displaced. The absence of an upward shift of group 2 values in the setting of an augmented preload suggests that these patients maintained only a normal level of ventricular performance with the use of preload reserve and were operating at a somewhat reduced contractile state. The downward displacement of group 3 data points in the presence of only moderately higher levels of afterload than in groups 1 and 2 implies impaired myocardial contractility. Recognition of chronic mitral regurgitation as a stress overload state may provide insight into the mechanism of myocardial injury that occurs in both volume and pressure overload. Circulation 76, No. 1, 59-67, 1987. IN CHRONIC mitral regurgitation, the preserved left ventricular ejection performance and paucity of clinical symptoms during the course of the disease are attributed to favorably altered loading conditions.l4

Impact of Papillary Muscle Infarction on Ischemic Mitral Regurgitation Assessed by Magnetic Resonance Imaging

“…In two patients both the anterior and posterior PM were affected thus resulting in four patients with anterior PM and nine patients with posterior PM involvement and in summary eleven patients with PM infarction. consecutively increased end-systolic volume [24,25]. Our results are in concordance with these reports, as the end-systolic volume was significantly increased in patients with ischemic mitral regurgitation.…”

Echocardiographic prediction of survival after surgical correction of organic mitral regurgitation.

“…(1) The potential beneficial impact of valve repair on survival is controversial26'49 and has been analyzed separately.61 (2) The current study demonstrates that left ventricular dysfunction is associated with excess late mortality even in patients who have a valve repair. (3) Preoperative variables remained independent predictors of survival in a combined model incorporating the type of correction performed. Thus, the preoperative status of patients, in particular the echocardiographic assessment of left ventricular function, should always be incorporated in the clinical decision making.…”

Real-Time Left Ventricular Pressure-Volume Loops During Percutaneous Mitral Valve Repair With the MitraClip System

“…LV preload and afterload were estimated from end-diastolic (WS ED ) and end-systolic (WS ES ) wall stress, 19,20 respectively, which were calculated according to the following equation for time-dependent WS:…”