The Relationship of Age With Regional Aortic Stiffness and Diameter

Hickson, Stacey S.; Butlin, Mark; Graves, Martin J.; Taviani, Valentina; Avolio, Alberto; McEniery, Carmel M.; Wilkinson, Ian B.

doi:10.1016/j.jcmg.2010.09.016

Cited by 196 publications

(204 citation statements)

References 27 publications

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“…9,10 The observation of markedly higher stiffness in the ascending as compared to the descending aorta, which is only a dozen centimeters downstream, 17 is not supported by studies of regional transit time PWV, which found a persistent positive stiffness gradient moving distally along the aorta in older people. 18 After adjusting for longitudinal strain, circumferential strain in the ascending aorta was comparable to strain in the descending aorta, which suggests that with age, proximal Figure 7. Lumen area strain of the ascending and descending aorta for women (red) and men (blue).…”

Section: Discussionmentioning

confidence: 94%

Po-01 Longitudinal and Circumferential Strain of the Proximal Aorta

Bell

Mitchell

Sigurðsson

et al. 2014

ARTRES

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Background--Accurate assessment of mechanical properties of the proximal aorta is a requisite first step for elucidating the pathophysiology of isolated systolic hypertension. During systole, substantial proximal aortic axial displacement produces longitudinal strain, which we hypothesize causes variable underestimation of ascending aortic circumferential strain compared to values in the longitudinally constrained descending aorta.

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Section: Discussionmentioning

confidence: 94%

Po-01 Longitudinal and Circumferential Strain of the Proximal Aorta

Bell

Mitchell

Sigurðsson

et al. 2014

ARTRES

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“…Area-based parameters and aortic volume allow to quantitatively describe aortic enlargement, that has been correlated with arterial stiffening [45] and, ultimately, to systemic risk factors such as hypertension. Among possible scenarios, an increased aortic volume, as the one observed here for PG ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

Gallo

Vardoulis

Monney

et al. 2017

Medical Engineering & Physics

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a b s t r a c tIn this study, an image-based morphometry toolset quantifying geometric descriptors of the left ventricle, aorta and their coupling is applied to investigate whether morphological information can differentiate between subjects affected by diastolic dysfunction (patient group) and their age-matched controls (control group). The ventriculo-aortic region of 20 total participants (10 per group) were segmented from highresolution 3D magnetic resonance images, from the left ventricle to the descending aorta. Each geometry was divided into segments in correspondence of anatomical landmarks. The orientation of each segment was estimated by least-squares fitting of the respective centerline segment to a plane. Curvature and torsion of vessels' centerlines were automatically extracted, and aortic arch was characterized in terms of height and width.Tilt angle between subsequent best-fit planes in the left ventricle and ascending aorta regions, curvature and cross-sectional area in the descending aorta resulted significantly different between patient and control groups ( P -values < 0.05). Aortic volume ( P = 0.04) and aortic arch width ( P = 0.03) resulted significantly different between the two groups. The observed morphometric differences underlie differences in hemodynamics, by virtue of the influence of geometry on blood flow patterns.The present exploratory analysis does not determine if aortic geometric changes precede diastolic dysfunction, or vice versa. However, this study (1) underlines differences between healthy and diastolic dysfunction subjects, and (2) provides geometric parameters that might help to determine early aortic geometric alterations and potentially prevent evolution toward advanced diastolic dysfunction.

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“…The thoracic aorta increases in diameter, elongates, and stiffens with advancing age 1, 2, 3, 4. Aortic arch width (AAW)5, 6 also increases with older age.…”

Section: Introductionmentioning

confidence: 99%

“…Aortic arch width (AAW)5, 6 also increases with older age. These changes in aortic geometry are cross sectionally associated with excess burden of undesirable hemodynamic and cardiac structural changes 1, 4, 6. Furthermore, increasing aortic stiffness may be more a precursor than a result of hypertension 7.…”

Section: Introductionmentioning

confidence: 99%

Aortic Arch Width and Cardiovascular Disease in Men and Women in the Community

Chuang

Gona

Qazi

et al. 2018

JAHA

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BackgroundWe sought to determine whether increased aortic arch width (AAW) adds to standard Framingham risk factors and coronary artery calcium (CAC) for prediction of incident adverse cardiovascular disease (CVD) events in community‐dwelling adults.Methods and ResultsA total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify CAC. We measured AAW as the distance between the centroids of the ascending and descending thoracic aorta, at the level of main pulmonary artery bifurcation or the right pulmonary artery. We determined sex, age group, and body size specific cut points for high (≥90th percentile) AAW from a healthy referent group (N=1471) and dichotomized AAW as high or not high across all study participants. Clinical covariates were obtained at Offspring cycle 7 (1998–2001) or Third Generation cycle 1 (2002–2005) examinations. The primary CVD outcome was a composite of myocardial infarction, coronary insufficiency, cerebrovascular accident, first hospitalization for heart failure, or CVD death. Cox proportional hazards models were used to estimate hazard ratio of high AAW on time‐to‐incident CVD after adjustment for Framingham risk factors and CAC. Net reclassification improvement was used to assess the effect of adding AAW to the baseline Framingham risk factor+CAC model. A total of 2826 participants (aged 51±11 years, 48% women) had complete covariates and were free of CVD at multidetector computed tomography. Over a median 8.9 years of follow‐up, there were 135 incident CVD events. High AAW was independently predictive of CVD events (hazard ratio, 1.55; P=0.032) and appropriately reclassified participants at risk: net reclassification improvement, 0.31 (95% confidence interval, 0.15–0.48).Conclusion AAW augments traditional CVD risk factors and CAC for prediction of incident adverse CVD events among community‐dwelling adults.

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The Relationship of Age With Regional Aortic Stiffness and Diameter

Abstract: The greatest difference in aortic stiffness occurs in the abdominal region, whereas the greatest difference in diameter occurs in the ascending aorta, which may help offset an increase in wall stiffness.

Cited by 196 publications

References 27 publications

Po-01 Longitudinal and Circumferential Strain of the Proximal Aorta

Po-01 Longitudinal and Circumferential Strain of the Proximal Aorta

Cardiovascular morphometry with high-resolution 3D magnetic resonance: First application to left ventricle diastolic dysfunction

Aortic Arch Width and Cardiovascular Disease in Men and Women in the Community

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