The relationship of agenesis of the lung to emphysema and cor pulmonale

Warner, Alberta; Palladino, Nicola; Schwartz, W. S.; Schuster, Andreas

doi:10.1016/s0022-3476(55)80212-0

Cited by 11 publications

(4 citation statements)

References 12 publications

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“…In 1955 Hochberg and Naclerio reviewed 100 cases and stated that' they could find "less than 150 cases reported in the medical journals." Single cases have been reported from time to time in the American literature, notably by Warner et al (1955) and Steiner (1956).…”

Section: Resultsmentioning

confidence: 99%

Pulmonary Agenesis

Jones¹,

Howells²

1961

BMJ

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Section: Resultsmentioning

confidence: 99%

Pulmonary Agenesis

Jones¹,

Howells²

1961

BMJ

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“…12 Normal or increased residual volumes were demonstrated with considerable interindividual variability. [17][18][19][20] Most authors agree that emphysema is usually not present. Quantitative analysis at autopsy of a 3-month-old boy with right-sided aplasia demonstrated that the number of alveoli of the enlarged single lung was twice normal, whereas alveolar size was reduced.…”

Section: Discussionmentioning

confidence: 99%

Right-sided pulmonary aplasia: Longitudinal lung function studies in two cases and comparison to results from term healthy neonates

et al. 1998

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Agenesis of the right lung was diagnosed prenatally in two neonates born at 36 and 37 weeks, respectively. Computed tomographic scans and magnetic resonance imaging indicated that both cases had a Type 2 pulmonary agenesis, which was confirmed later by bronchoscopy. Both patients were clinically stable during the neonatal period. Serial pulmonary function tests revealed a decrease in specific respiratory system compliance (sCrs) in both neonates and a marked discrepancy between functional residual capacity measured by the nitrogen washout technique (FRCN2) and by plethysmography (FRCpleth) on follow‐up. Early decrease of respiratory system compliance (Crs) and increase of respiratory system resistance (Rrs) in one infant preceded the onset of tracheal stenosis, which remained asymptomatic until the age of 8 weeks, when the infant developed acute respiratory failure requiring intubation and mechanical ventilation with high airway pressures. Aortopexy, implantation of a tissue expander into the right hemithorax, and laser ablation of fibrotic tissue at the site of tracheal stenosis were performed to achieve successful extubation. The second infant remained asymptomatic. Values for lung mechanics and volumes for both infants with pulmonary aplasia were as follows: Crs, 3.43 and 10.60 mL · kPa−1 · kg−1; sCrs, 0.23 and 1.28 kpa−1; Rrs, 11.1 and 7.4 kpa · s · L−1; FRCN2, 14.9 and 10.2 mL · kg−1; FRCpleth, 28.2 and 25.8 mL · kg−; FRCN2: FRCpleth ratio, 0.56 and 0.54 for patients 1 and 2, respectively. These values differed considerably from results of a control group of nine term healthy neonates (Crs, 10.0 ± 1.8 mL · kPa−1 · kg−1; sCrs, 0.43 ± 0.08 kpa−1; Rrs, 5.10 ± 0.55 kpa · s · L−1; FRCN2, 24.0 ± 2.5 mL · kg−1; FRCpleth, 31.1 ± 6.0 mL · kg−1; FRCN2:FRCpleth ratio, 0.78 ± 0.10). In conclusion, serial assessment of lung mechanics and pulmonary gas volumes detects airway obstruction early in neonates with unilateral lung agenesis. Bronchoscopy is recommended. Along with conventional surgical procedures, an expandable implant may improve management or prevent respiratory failure in selected cases. Pediatr Pulmonol. 1998; 26:138–144. © 1998 Wiley‐Liss, Inc.

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“…The last author collected and tabulated details of 120 cases. Since Valle's (1955) publication, cases have been reported by Warner, Palladino, Schwartz, and Schuster (1955);Clark, Scott, and Johnson (1955); Hochberg and Naclerio (1955); Levy (1955); Bariety, Choubrac, Vaudour, Tupin, and Manouvrier (1955); Sinchez Barrios and Escobar Aces (1956); Rouco Aja ', Codinach, and Segura (1956) ; Chambers and Tancredi (1957); and Netterville (1957). A list of references to the early work on the subject will be found in Smart's (1946) paper. We now report the findings in four proven cases of total agenesis of a lung and discuss certain features of the disease, in particular, some aspects affecting the clinical management of the condition.…”

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confidence: 99%

“…Its value in preventing overdistension of the existing lung is also a matter for coniecture. There are two descriptions of full respiratory function studies in children with pulmonary agenesis, those of Warner et al (1955) andClark et al (1955). Neither of these groups of workers were convinced of the need for operation by the results they obtained.…”

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confidence: 99%