2009
DOI: 10.1038/mp.2008.136
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The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

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Cited by 44 publications
(14 citation statements)
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“…Interestingly, as opposed to the GM findings, both the Self Impact and the Social-Emotional Impact show an inverse correlation to WM integrity (i.e., FA) in the anterior thalamic radiations. The anterior thalamic radiation is the primary path from the ventral medial frontal cortex, inferior frontal gyrus, and dorsolateral prefrontal cortex to the thalamus [51] and shows reductions in relation to psychiatric conditions such as schizophrenia and bipolar disorder [52], [53]. In previous research we have found increases in this tract during adolescence longitudinally [21], the current research suggests that failure to increase FA in this region may accompany distortions of self world concept along affective domains.…”
Section: Discussionsupporting
confidence: 55%
“…Interestingly, as opposed to the GM findings, both the Self Impact and the Social-Emotional Impact show an inverse correlation to WM integrity (i.e., FA) in the anterior thalamic radiations. The anterior thalamic radiation is the primary path from the ventral medial frontal cortex, inferior frontal gyrus, and dorsolateral prefrontal cortex to the thalamus [51] and shows reductions in relation to psychiatric conditions such as schizophrenia and bipolar disorder [52], [53]. In previous research we have found increases in this tract during adolescence longitudinally [21], the current research suggests that failure to increase FA in this region may accompany distortions of self world concept along affective domains.…”
Section: Discussionsupporting
confidence: 55%
“…rs6994992,originally identified as part of the so-called deCODE haplotype, could be specifically related to disruption of normal frontal and temporal lobe function, premorbid intelligence levels and the emergence of psychotic symptoms (Harrison and Law, 2006; Li et al, 2006). Individuals with the TT genotype at this SNP also had reduced white matter density and structural connectivity (McIntosh et al, 2008), impaired frontal and temporal lobe activation (Hall et al, 2006), and cognition (Hall et al, 2006; Stefanis et al, 2007; Sprooten et al, 2009), including reduced spatial working memory capacity (Stefanis et al, 2007) and emotion processing (Keri and Kelemen, 2008). …”
Section: Discussionmentioning
confidence: 99%
“…In addition, white matter integrity across diffuse regions of the brain was found to correlate with cyclothymic personality traits, suggesting white matter deficits are related to bipolar symptoms even in unaffected individuals. Dr McIntosh’s group has begun to study the molecular genetic basis for these changes, showing that putative risk variants in the NRG-1 and Erb4 genes are related to white matter integrity of the anterior limb of the internal capsule and anterior thalamic radiation (McIntosh, et al, 2008; Sprooten, et al, 2009). …”
Section: Vi: Geneticsmentioning
confidence: 99%