The Relationship of Blood Uric Acid Content to the State of Renal Function in Nephritis

Johnston, C.

doi:10.1172/jci100320

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…It appears from work previously done that the urea clearance test of Van Slyke and his associates offers a much more accurate method of study of renal function than other tests in common usage. For example, it has been shown that the blood urea clearance must usually fall below fifty per cent of its normal value before significant changes occur in blood creatinin, blood urea nitrogen, blood uric acid, or phenolsulphonephthalein values, and that only after the urea clearance falls below twenty per cent of normal is there usually a change in all of the above values (1,2).…”

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confidence: 99%

The Urea Clearance Test in Toxemias of Pregnancy

Hurwitz¹,

Ohler²

1932

J. Clin. Invest.

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The patients were classified into toxemic, chronic nephritic and eclamptic groups and a normal pregnant control group. The dividing line between toxemia and chronic nephritis was frequently indefinite, but an attempt was made to include under chronic nephritis the following patients: those who had a definite history of nephritis just before becoming pregnant; those who had a high blood pressure and albuminuria in the early months of pregnancy (up to the fifth month); and those who continued with high blood pressure (over 160 mm. Hg systolic) for some months after delivery. A few of the last mentioned are probably not true nephritics at the present time, but for the purpose of this report are considered thus-until proved otherwise. Patients were classified as 1119

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confidence: 99%

The Urea Clearance Test in Toxemias of Pregnancy

Hurwitz¹,

Ohler²

1932

J. Clin. Invest.

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“…It has been reported that it may or may not be raised in nephritis with impaired kidney function (3), and that has been our ex-748 perience. In Table IV are given the results in a series of patients where the increase in blood uric acid may be explained on a basis other than gout.…”

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confidence: 68%

The Blood Uric Acid in Disease

Jordan

Gaston²

1932

J. Clin. Invest.

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Because of the large number of patients in the University of Chicago Clinics showing high blood uric acid by the Koch I modification of the Folin and Benedict methods using the Folin-Wu blood filtrate, it was decided to try a different method. The method which has seemed to to yield most satisfactory results is that described by Folin (1) in which he makes use of unlaked blood filtrate, a cyanide solution stabilized by means of urea, and a uric acid reagent free from phenol reagent. This method has been used for all uric acid determinations in the Medical department since May 1931, and has proved relatively satisfactory as a clinical method. The cyanide solution, which is kept at low temperature, retains its chromophoric power well, and when used with the uric acid reagent has produced no turbid solutions. It was, of course, necessary to determine a new series of normal blood uric acid values by this method, and while the results are not wholly free from unexplained high values (see Table V), it is believed that this method, as compared with the one formerly used, gives more satisfactory results.For the purpose of comparison a few samples of blood were tested simultaneously for uric acid by the Koch modification formerly used (hereafter called " old method ") and by the Folin method at present used. Two samples from a control patient, drawn on different days, gave 7.2 and 9.2 mgm. per 100 cc. by the old method and 3.9 and 3.8 mgm. per 100 cc. respectively by the new method. One sample from a patient with chronic gout gave 12.3 and 5.6 mgm. per 100 cc. by the old and new methods respectively. The uric acid in the blood of a patient with infectious arthritis was 5.3 and 2

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Urea Clearance Test as an Index of Renal Function

Bruger¹,

Mosenthal²

1932

Arch Intern Med (Chic)

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The Relationship of Blood Uric Acid Content to the State of Renal Function in Nephritis

Cited by 12 publications

References 9 publications

The Urea Clearance Test in Toxemias of Pregnancy

The Urea Clearance Test in Toxemias of Pregnancy

The Blood Uric Acid in Disease

Urea Clearance Test as an Index of Renal Function

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