The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study

Lyon, Debra E.; Cohen, Ronald A.; Chen, Huaihou; Kelly, Debra Lynch; Starkweather, Angela; Ahn, Hyochol; Jackson‐Cook, Colleen

doi:10.1007/s00432-016-2163-y

Cited by 34 publications

(38 citation statements)

References 53 publications

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“…A maioria dos estudos explorou, além das funções executivas, outros domínios cognitivos e sintomas concomitantes ao processo da avaliação (Ando-Tanabe, 2014, Askren et al, 2014Chen et al, 2013;Dumas, 2013;Ganz et al, 2003;Jansen, 2011;Kam et al, 2016;Kesler et al, 2011;Koppelmans et al, 2012;Lyon et al, 2016;McDonald et al, 2013;Miao et al, 2016;Park et al, 2015;Piccirillo, et al, 2015;Yao et al, 2016;Zheng et al, 2014). Apenas Kam et al (2016), Miao et al (2016) e McDonald et al (2013) delimitaram-se à investigação e discussão aos aspectos relevantes do funcionamento executivo.…”

Section: Resultsunclassified

“…Apenas o teste Stroop, visando à avaliação de controle inibitório, foi o mais utilizado (Chen et al, 2013;Jansen et al, 2011;Kam et al, 2016;Koppelmans et al, 2012;Lyon et al, 2016;Miao et al, 2016;Yao et al, 2016;Zheng et al, 2014). É possível conferir essa variabilidade de métodos de avaliação na Tabela 2.…”

Section: Resultsunclassified

“…Partindo para os resultados das pesquisas que aplicaram baterias de testes neuropsicológicos, a maioria dos subdomínios que correspondem às funções executivas mostraram-se alteradas em grupos de mulheres com câncer de mama em condição de quimioterapia (Chen e al., 2014;Ganz et al, 2003;Koppelmans, 2012;Lyon et al, 2016;Park et al, 2015;Yao et al, 2016;Zheng et al, 2014). Corroborando com esses dados, Askren et al (2014), Dumas (2013), Kam et al (2016), Kesler (2011;, Miao et al (2016), McDonald et al (2013) e Piccirillo et al (2015, ao examinarem imagens de ressonância magnética, observaram alterações em ligações funcionais nas redes cerebrais no que se refere à função executiva.…”

Section: Resultsunclassified

“…Finalmente, ressalta-se que, alguns estudos verificaram que houve melhoras do funcionamento executivo após a conclusão da quimioterapia (Ando-Tanabe, 2014; Chen et al, 2014;Dumas, 2013;Jansen, 2011;Lyon et al, 2016;Park et al, 2015;Zheng et al, 2014), sendo mais lenta em mulheres com idade mais avançada e de escolaridade baixa (Kesler et al, 2011;Zheng et al, 2014).…”

Section: Tabelaunclassified

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Mulheres Submetidas à Quimioterapia e suas Funções Cognitivas

Lima

Póvoa

2017

Psicol. cienc. prof.

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Resumo: Atualmente, o câncer representa um grande desafio científico. A quimioterapia tem sido a alternativa de tratamento de maior perspectiva para o combate ao câncer. Durante esse percurso, alterações cognitivas podem ser acarretadas e, portanto, faz-se necessário a identificação destas, já que representam complicações neurológicas com alto índice de melhora quando tratadas. O objetivo desse trabalho delimitou-se a estudar as funções executivas em mulheres com câncer de mama submetidas à quimioterapia buscando identificar aspectos como flexibilidade cognitiva, impulsividade/controle inibitório, memória operacional, planejamento, tomada de decisão, categorização e fluência. Trata-se de uma revisão de literatura a partir de levantamento de publicações dos últimos cinco anos nas bases de dados PubMed, Lilacs, Pepsico, SciELO e BVS. Foram utilizados os seguintes descritores: avaliação neuropsicológica/neuropsychological evaluation, funções executivas/functions executive, quimioterapia/chemotherapy e câncer de mama/breast cancer. Foram encontrados 18 artigos relacionados ao tema. Os estudos apontaram a existência de alterações no funcionamento executivo de mulheres submetidas à quimioterapia. Ressalta-se que essas pesquisas se diferenciaram entre si, no que se refere à caracterização da amostra e a métodos utilizados, o que demonstra pouca padronização da avaliação neuropsicológica desse domínio cognitivo. Conclui-se que os domínios cognitivos referentes às funções executivas se encontram mais prejudicados em mulheres com câncer de mama que receberam quimioterapia. Contudo, essas informações ainda são insuficientes, pois subdomínios das funções executivas precisam ser investigados com maior integralidade, a fim de se obter um maior panorama funcional. Sugere-se novos estudos acerca do rastreio das funções executivas. Palavras-chave:Câncer de mama Quimioterapia, Funções executivas.

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Mulheres Submetidas à Quimioterapia e suas Funções Cognitivas

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Póvoa

2017

Psicol. cienc. prof.

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“…Memory impairment is one of the main complaints by patients with breast cancer [83][84][85] and has been linked to inflammatory processes [86,87]. It was demonstrated that breast cancer patients harbouring the IL6-174 GG and TNF-308 GG genotypes had near significant worse memory complaints [61].…”

Section: Memory and Cognitive Functionmentioning

confidence: 99%

Genetic polymorphisms associated with common symptoms experienced by breast cancer patients

Abubakar

Gan²

2018

biomedicalresearch

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The recent advances have led to a considerable increase in the proportion of breast cancer survivors, however, majority of them experience symptoms such as fatigue, pain, depression and sleep disturbances that impair their Quality of Life (QOL) significantly. In addition, a significant inter-individual variability in QOL of breast cancer patients exists which has been partly attributed to genetic variations. However, details of how these variations are influenced by genetic factors remain largely unknown. Therefore, detecting patients with greater susceptibility to reduced QOL using genetic markers may help in designing intervention strategies for personalized medicine. Although limited number of studies have reported on the associations between genetic polymorphisms and QOL, cytokine gene polymorphisms has consistently been linked to increased susceptibility to the development of common symptoms (fatigue, pain, depression and sleep disturbances) in breast cancer patients. More interestingly, these symptoms share some common molecular pathways making it possible to consider them as symptom cluster. In this review, the relationship between genetic variation and common symptoms among breast cancer patients is discussed. In order for genetic factors to be integrated into clinical practice and nursing care of breast cancer patients with impaired QOL, additional studies are encouraged to understand the underlying molecular mechanisms involved in the development of these symptoms and their impact on QOL for identification of patients based on the presence of a symptom cluster using genetic biomarkers.

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Altered gyrification in chemotherapy‐treated older long‐term breast cancer survivors

Daniel,

Deng,

Patel

et al. 2024

Brain and Behavior

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PurposeThe purpose of this prospective longitudinal study was to evaluate the changes in brain surface gyrification in older long‐term breast cancer survivors 5–15 years after chemotherapy treatment.MethodsOlder breast cancer survivors aged ≥ 65 years treated with chemotherapy (C+) or without chemotherapy (C‐) 5–15 years prior and age‐ and sex‐matched healthy controls (HC) were recruited (time point 1 (TP1)) and followed up for 2 years (time point 2 (TP2)). Study assessments for both time points included neuropsychological (NP) testing with the NIH Toolbox cognition battery and cortical gyrification analysis based on brain MRI.ResultsThe study cohort with data for both TP1 and TP2 consisted of the following: 10 participants for the C+ group, 12 participants for the C‐ group, and 13 participants for the HC group. The C+ group had increased gyrification in six local gyral regions including the right fusiform, paracentral, precuneus, superior, middle temporal gyri and left pars opercularis gyrus, and it had decreased gyrification in two local gyral regions from TP1 to TP2 (p < .05, Bonferroni corrected). The C‐ and HC groups showed decreased gyrification only (p < .05, Bonferroni corrected). In the C+ group, changes in right paracentral gyrification and crystalized composite scores were negatively correlated (R = –0.76, p = .01).ConclusionsAltered gyrification could be the neural correlate of cognitive changes in older chemotherapy‐treated long‐term breast cancer survivors.

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The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study

Cited by 34 publications

References 53 publications

Mulheres Submetidas à Quimioterapia e suas Funções Cognitivas

Mulheres Submetidas à Quimioterapia e suas Funções Cognitivas

Genetic polymorphisms associated with common symptoms experienced by breast cancer patients

Altered gyrification in chemotherapy‐treated older long‐term breast cancer survivors

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