The relationship of cytokine status with left ventricular hypertrophy in patients with arterial hypertension

Abstract

Aim. To study the relationship of tumor necrosis factor α and interleukin-10 levels with the presence of left ventricular hypertrophy and myocardial remodeling in patients with arterial hypertension. Metods. 156 patients with hypertension aged 40 to 75 years (mean age 55.8±7.5 years), including 57 women and 99 men were examined. All patients were divided into two groups. Group 1 included 83 patients without left ventricular hypertrophy (55.5±7.5 years), group 2 included 73 patients with left ventricular hypertrophy (56.2±7.8 years), established by echocardiographic signs. All patients in addition to the general clinical examination and biochemical studies had echocardiography and Doppler echocardiography performed, as well as measurement of the concentration of tumor necrosis factor α and interleukin-10 by solid-phase enzyme immunoassay using specialized «Cytokine-Stimulus-Best» kit (Novosibirsk, Russia). Results. The concentration of tumor necrosis factor α in patients without left ventricular hypertrophy was 8.43±1.36 pg/ml and was comparable with the concentration of this cytokine in patients with left ventricular hypertrophy (8.54±1.58 pg/ml, p >0.05). This pattern was typical for both men and women. The concentration of interleukin-10 in both groups was also comparable (15.4±3.6 pg/ml in group 1 and 14.7±3.4 pg/ml in group 2, p >0.05). However, we identified gender-specific features in the relationship of interleukin-10 with the presence of left ventricular hypertrophy in patients with hypertension. Thus, while in women the concentration of cytokine in groups with/without left ventricular hypertrophy did not differ significantly, in men without hypertrophy the level of interleukin-10 of 15.7±3.6 pg/ml, was significantly higher than the value of the same indicator in the group of men with left ventricular hypertrophy (14.8±2.9 pg/ml, p <0.025). Multivariate regression analysis showed that tumor necrosis factor α and interleukin-10 concentrations correlated to left ventricular wall thickness in patients without left ventricular hypertrophy. No such pattern was revealed for patients with hypertrophy. Conclusion. The results demonstrate the modulating role of tumor necrosis factor α and interleukin-10 in myocardial remodeling processes in arterial hypertension.

Features of compensatory and adaptive reactions of the vascular bed of the bladder of elderly and senile men with prostatic hyperplasia

“…Замыкающие артерии, имеющие хорошо выраженный продольный слой гладких мышц в интиме, способствуют адаптации расстройств кровообращения в мышечной оболочке пузыря. Развитие хронической ишемии детрузора сопровождается атрофически-склеротическими изменениями одних участков гладкой мускулатуры при сохранении других, что не противоречит принципу «функциональной гетерогенности в работе одноименных структур», согласно которому любой орган, с одной стороны, в покое не использует для выполнения функции все структуры одновременно, а с другой стороны, включает в работу все имеющиеся структурные ресурсы и резервы, подвергающиеся гипертрофии при увеличении функциональной нагрузки [15][16][17]. Как показали наши исследования, ГПЖ у мужчин пожилого и старческого возраста приводит к рабочей компенсаторной гипертрофии детрузора, выражающейся в гиперплазии и гипертрофии ранее не измененных мышечных волокон, в межмышечной строме которых возрастает степень капилляризации, столь необходимая для обеспечения активно функционирующей ткани.…”