The relationship of endometriosis and ovarian malignancy: a review

Nezhat, Farr; Datta, Meghna; Hanson, Veneta; Pejović, Tanja; Nezhat, Ceana; Nezhat, Camran

doi:10.1016/j.fertnstert.2008.08.007

Cited by 217 publications

(173 citation statements)

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“…Recent data demonstrated, for example, an association between PTEN, P53, and BCL2 gene mutations and human endometriosis and ovarian cancer (Nezhat et al, 2008). According to the authors, these mutations might correlate with a genetic transition to malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…The absence of symptoms leads most patients to seek specialized services during late clinical stages of the disease (Fehrmann et al, 2007). Recent data have demonstrated the presence of common mutations in the PTEN, P53, and BCL2 genes in ovarian cancers and in adjacent endometriotic lesions, thus suggesting a possible malignant genetic transition spectrum (Nezhat et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer

Monteiro¹,

Boas²,

Gigliotti³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Endometriosis is a complex disease that has both benign and malignant characteristics. It affects 5-10% of women of reproductive age. Studies have demonstrated the existence of common genetic changes in endometriosis and ovarian cancer, suggesting a possible association between these 2 diseases. However, the mechanisms that lead to the development of cancer from endometriosis remain unknown. In this study, we evaluated 3 groups of women: 72 patients with endometriosis, 70 with ovarian cancer, and 70 healthy individuals (controls). Repair (XRCC1 codons 194 and 399, XPD codons 312 and 751, and XRCC3 codon 241)-and metabolism (BLHX codon 443)-related gene polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism technique; the efficiency of DNA damage repair was analyzed in vitro 637 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (1): 636-648 (2014) Chromosome instability in endometriosis and ovarian cancer in lymphocytes exposed to bleomycin. The logistic regression model was used to evaluate key associations. The results showed an increased average of chromosome breakage in bleomycin-treated lymphocytes from patients with endometriosis and ovarian cancer compared with healthy women. We also detected significant association between XRCC1, XRCC3, and BLHX polymorphisms and a high frequency of chromosomal damage. Women with endometriosis or ovarian cancer may have an altered mechanism of DNA repair, and these defects may be related to a higher incidence of ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer

Monteiro¹,

Boas²,

Gigliotti³

et al. 2014

Genet. Mol. Res.

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“…Penelitian Hadisaputra, 2013, didapatkan VEGF berbanding lurus dengan derajat dan prognosis yang buruk pada endometriosis (Hadisaputra W, Prayudhana S, 2013). IL-1 β pun merangsang cyclooxygenase 2 (COX2) memproduksi prostaglandin (PG) E 2, merangsang gen steroidogenik dan menekan reseptor gonadothrophin releasing hormone (GnRH) (Nezhat et al, 2008). Semua kondisi tersebut, pada jangka waktu lama akan memicu proliferasi dan mempengaruhi kemampuan DNA untuk memperbaiki diri, sehingga ditemukan resiko keganasan epithelial ovarium meningkat sebanyak 3 kali lipat (resiko relatif 1.9 sampai 4.2) (Keita et al, 2011;Furuya, 2012;Robboy et al, 2009).…”

Section: Pendahuluanunclassified

“…Beberapa penelitian, termasuk yang dilakukan oleh Maccio dkk, menunjukkan adanya korelasi antara derajat inflamasi kronik, stadium lanjut dan hasil akhir yang buruk pada pasien EAOC (Munksgaard PS, Blaakaer J, 2011;Nezhat et al, 2008;Worley et al, 2013;Macciò, and Madeddu, 2012).…”

Section: Hasil Dan Pembahasanunclassified

Ekspresi Interleukin-1 (Il-1) Β Pada Endometriosis, Karsinoma Endometrioid Dan Karsinoma Serosum Ovarium

Lestari¹,

Amarwati²,

Sadhana³

et al. 2017

Biomedika

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ABSTRAK Kata kunci: Endometriosis, interleukin-1β, karsinoma endometrioid, karsinoma serosum ABSTRACT Ovarian endometriosis is associated with an increased risk of ovarian epithelial carcinoma (RR 1.9-4.2). Endometrioid carcinoma is one of the most common type of malignancy associated with endometriosis, while serous carcinoma is the most common ovarian cancer type. It has been reported that sera pro-inflammatory interleukin-1 (IL-1) β evidently be involved in both endometriosis (p = 0,034 and p=0,020), while group B vs group C was not significant (p = 0,805). There are some differences in IL-1β expression among ovarian endometriosis, endometrioid carcinoma, and serosum carcinoma, but there are no significantly difference between ovarian endometrioid carcinoma and serosum carcinoma.

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“…Развитие эндометриоидных гетеротопий в яичниках и по брюшине наблюдается у каждой 3-й больной с симптомами хронической тазовой боли и наруше-нием менструального цикла [5]. Проявляясь как хро-ническое воспалительное заболевание, эндометриоз приобретает свойства злокачественных опухолей: на-личие не только локальных, но и отдаленных очагов, способность клеток к миграции, инвазии и поврежде-нию окружающих тканей [6].…”

Section: обзорные статьиunclassified