The relationship of family characteristics and bipolar disorder using causal-pie models

Chen, Y.-C.; Kao, Cheng−Yan; Lü, Ming; Yang, Yen Kuang; Liao, Shih‐Cheng; Jang, Fong Lin; Chen, W.J.; Lu, Ru‐Band; Kuo, Po-Hsiu

doi:10.1016/j.eurpsy.2013.05.004

Cited by 13 publications

(10 citation statements)

References 48 publications

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“…Family functioning is often poor for those with bipolar disorder (43). In prospective research, family impairment has been shown to predict depressive more than manic symptoms among adults (39, 44, 45).…”

Section: Low Social Supportmentioning

confidence: 99%

“…Causal interpretations of family functioning on the course of adolescent bipolar disorder, however, must be approached cautiously. One of the strongest predictors of risk of bipolar disorder is parental psychopathology (43). In addition, family conflict may arise as parents attempt to exert control over the manic symptoms they observe in their children.…”

Section: Low Social Supportmentioning

confidence: 99%

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The Influence of Trauma, Life Events, and Social Relationships on Bipolar Depression

Johnson

Cuellar

Gershon

2016

Psychiatric Clinics of North America

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Synopsis A growing body of research suggests that the social environment exerts a powerful influence on the course of bipolar depression. We review longitudinal research to suggest that trauma, negative life events, social support deficits, and family difficulties are common and predict a more severe course of depression when present among those diagnosed with bipolar disorder. The triggers of bipolar depression overlap with those documented for unipolar depression, suggesting that many of the treatment targets for unipolar depression may be applicable for bipolar depression.

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Section: Low Social Supportmentioning

confidence: 99%

Section: Low Social Supportmentioning

confidence: 99%

The Influence of Trauma, Life Events, and Social Relationships on Bipolar Depression

Johnson

Cuellar

Gershon

2016

Psychiatric Clinics of North America

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“…Variables entered into the model included all those with a P ≤0.2 from the univariate analyses. SUD, whether present in the family or in the patient, even if the P >0.2, was also entered into the model of analysis because of its theoretical association with BD 23. In the final step of the regression analysis, the variables that still had a statistical significant positive association with AD comorbidity were age at onset of BD (odds ratio =0.95, 95% confidence interval [CI] =0.93–0.97, P <0.01), SUD in the patient’s family (odds ratio =2.18, 95% CI =1.11–4.27, P =0.02), and a higher MADRS (odds ratio =1.10, 95% CI =1.06–1.15, P <0.01) (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Risk factors for an anxiety disorder comorbidity among Thai patients with bipolar disorder: results from the Thai Bipolar Disorder Registry

Paholpak¹,

Kongsakon²,

Pattanakumjorn³

et al. 2014

NDT

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BackgroundThe aim of the study was to determine in a clinical setting the risk factors for current anxiety disorder (AD) comorbidity among Thai patients with bipolar disorder (BD), being treated under the Thai Bipolar Disorder Registry Project (TBDR).MethodsThe TBDR was a multisite naturalistic study conducted at 24 psychiatric units (ie, at university, provincial mental, and government general hospitals) between February 2009 and January 2011. Participants were in- or out-patients over 18 years of age who were diagnosed with BD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Instruments used in this study included the Thai Mini International Neuropsychiatric Interview version 5; Thai Montgomery–Åsberg Depression Rating Scale (MADRS); Thai Young Mania Rating Scale; Clinical Global Impression of Bipolar Disorder-Severity (CGI-BP-S), CGI-BP-S-mania, CGI-BPS-depression, and CGI-BP-S-overall BP illness; and the Thai SF-36 quality of life questionnaire.ResultsAmong the 424 BD patients, 404 (95.3%) had BD type I. The respective mean ± standard deviation of age of onset of mood disturbance, first diagnosis of BD, and first treatment of BD was 32.0±11.9, 36.1±12.2, and 36.2±12.2 years. The duration of illness was 10.7±9.0 years. Fifty-three (12.5%) of the 424 participants had a current AD while 38 (9%) had a substance use disorder (SUD). The univariate analysis revealed 13 significant risks for current AD comorbidity, which the multivariate analysis narrowed to age at first diagnosis of BD (odds ratio =0.95, P<0.01), family history of SUD (odds ratio =2.18, P=0.02), and having a higher current MADRS score (odds ratio =1.11, P<0.01).ConclusionA diagnosis of AD comorbid with BD is suggested by early-age onset of BD together with a higher MADRS score and a family history of SUD. The likelihood of AD comorbidity decreases by 5% with each passing year; early-age onset of BD is a risk while later age onset is protective. Our results underscore how SUD within the family significantly contributes to the risk of an AD comorbidity.

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“…This finding is consistent with previous reports in of poorer outcomes in offspring of BD probands with SUD. 32,40 This strongly suggests a need for early intervention with parents with BD and SUD, and suggests that treatment interventions for parents with this comorbidity is an important part of treating their offspring who are presenting with Axis I disorders as well. Finally, OBD with comorbid Axis I diagnoses who had personal diagnosis of MDD or BD also reported more frequent independent stressful life events.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Stressful Life Events and Axis I Diagnoses Among Adolescent Offspring of Probands With Bipolar and Non-Bipolar Psychiatric Disorders and Healthy Controls

Pan¹,

Goldstein²,

Rooks³

et al. 2017

J. Clin. Psychiatry

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Background Previous studies have explored the role of stressful life events in the development of mood disorders. We examined the frequency and nature of stressful life events as measured by the Stressful Life Events Scale(SLES) among three groups of adolescent offspring of probands: with bipolar(BD), with non-BD psychiatric disorders, and healthy control(HC). Furthermore, we examined the relationship between stressful life events and presence of DSM-IV Axis I disorders in these offspring. Stressful life events were characterized as dependent, independent, or uncertain (neither dependent or independent), and positive, negative, and neutral (neither positive or negative). Method Offspring of probands with BD aged 13–18 years(N=269), demographically-matched offspring of probands with non-BD Axis I disorders(N=88), and HC probands(N=81) from the Pittsburgh Bipolar Offspring Study were assessed from 2002–2007 with standardized instruments at intake. Probands completed the SLES for their offspring for life events within the prior year. Life events were evaluated with regard to current offspring Axis I diagnoses after adjusting for confounds. Results After adjusting for demographic and clinical between-group differences(in probands and offspring), offspring of BD probands had greater independent and neutral life events compared with HC offspring and greater number of more severe stressful life events than HC offspring, but not non-BD offspring. Offspring of BD probands with comorbid substance use disorder reported more independent stressful life events. Greater frequency and severity of stressful life events were associated with current Axis I disorder in offspring of both BD and non-BD affected probands regardless of dependency or valence. Greater frequency and severity of stressful life events were associated with greater current Axis I disorder in all offspring. Conclusions Offspring of BD probands have greater exposure to independent and neutral life events than HC offspring. Greater frequency and severity of stressful life events was associated with Axis I disorder in offspring of both BD and non-BD affected probands.

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The relationship of family characteristics and bipolar disorder using causal-pie models

Cited by 13 publications

References 48 publications

The Influence of Trauma, Life Events, and Social Relationships on Bipolar Depression

The Influence of Trauma, Life Events, and Social Relationships on Bipolar Depression

Risk factors for an anxiety disorder comorbidity among Thai patients with bipolar disorder: results from the Thai Bipolar Disorder Registry

The Relationship Between Stressful Life Events and Axis I Diagnoses Among Adolescent Offspring of Probands With Bipolar and Non-Bipolar Psychiatric Disorders and Healthy Controls

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