The Relationship of Fasting Plasma Glucose Values and Other Variables to 2-h Postload Plasma Glucose in Japanese Subjects

Abstract

OBJECTIVE -To investigate the relationship between fasting plasma glucose (FPG) values and other variables (e.g., age, sex, and BMI) to 2-h post-75-g oral glucose load glycemia (PG) in Japanese subjects.RESEARCH DESIGN AND METHODS -Subjects included 13,694 Japanese subjects between 20 and 83 years of age (10,677 men and 3,017 women) who were undergoing a 75-g oral glucose tolerance test (OGTT) during a health screening performed at our hospital. The influences of age for 2-h PG at a fixed fasting plasma glucose (FPG) level of 126 mg/dl were analyzed. Multiple linear regression analysis was performed using a model in which the dependent variable was 2-h PG using the following explanatory variables: FPG, age, sex, BMI, blood pressure, plasma cholesterol, and triglyceride (TG) levels.RESULTS -The 2-h PG at a fixed FPG of 126 mg/dl increased by 0.94 mg/dl per year in patients aged between 30 and 78 years (r ϭ 0.68, P Ͻ 0.0001). In multiple regression, five explanatory variables (FPG, age, BMI, plasma TG levels, and systolic blood pressure levels) were all positively associated with 2-h PG. The percentages of patients with 2-h diabetes (isolated postchallenge hyperglycemia [IPH]) versus fasting plus 2-h diabetes by the World Health Organization criteria significantly (P ϭ 0.005) increased as the patients' decades increased, whereas the impact of BMI on the percentages was significant only in young patients (P ϭ 0.001).CONCLUSIONS -Aging was found to be the second best predictor of 2-h PG on multiple regression. Therefore, OGTT should be performed especially in elderly patients because they show IPH more frequently.

Low association between fasting and OGTT stimulated glucose levels with HbA1c in overweight children and adolescents

“…These results confirm our hypothesis indicating that in general the measurement of 2‐hour OGTT glucose values cannot be replaced by determining FPG, and vice versa. They also support the results of a study conducted in a North Indian population but contrast with those from adult studies conducted in Japan and in India 17‐20 …”

Factors responsible for age-related elevation in fasting plasma glucose: a cross-sectional study in Japanese men

“…Fasting plasma glucose increased by 0.011 mmol/L per year, in accord with previous reports [30]. The HOMA-β decreased by 0.85% per year, clearly indicating reduced basal insulin secretion.…”

Predicting isolated postchallenge hyperglycaemia: a new approach; Tehran Lipid and Glucose Study (TLGS)

“…Many studies have reported the relation of age and gender to postload glycaemia [10,11,13,39–44]. Bando et al .…”

“…Bando et al . [11] studied 13 694 Japanese subjects aged between 20 and 83 years and found that age, BMI, SBP and TG influence the 2‐hPG value independently of the FPG. There are some differences between our results and the Japanese study.…”