The relationship of fatigue in breast cancer survivors with quality of life and factors to address in psychological interventions: A systematic review

Abrahams, H.J.G.; Gielissen, Marieke; Verhagen, C.A.H.H.V.M.; Knoop, Hans

doi:10.1016/j.cpr.2018.05.004

Cited by 114 publications

(114 citation statements)

References 86 publications

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“…This pinpoints the importance of having a biopsychosocial or holistic view of YACS during cancer treatment and survivorship. In line with this, newer research stresses the importance of viewing all these negative outcomes as being connected and be seen more as symptom clusters and predictors for impaired function and QOL than single negative outcomes (Abrahams, Gielissen, Verhagen and Knoop (2018);Fisher et al, 2018;Abrahams, Gielissen, Verhagen &Knoop, 2018).…”

Section: Discussionmentioning

confidence: 99%

“It's been a life‐changing experience!” A qualitative study of young adult cancer survivors’ experiences of the coexistence of negative and positive outcomes after cancer treatment

Hauken

Grue

Dyregrov

2019

Scandinavian J Psychology

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The aim of this study was to illuminate the coexistence of negative and positive experiences of young adult cancer survivors after cancer treatment. Using an interpretive descriptive design, 20 young adult cancer survivors were interviewed. The participants stated that the cancer was a life‐changing experience followed by both negative and positive outcomes. The range of negative outcomes was identified in the main theme “the cancer still hampers me,” subdivided into three subthemes “impaired function and changed body,” “intrusion of thoughts and feelings” and “negative impact on relationships.” Simultaneously, the informants experienced positive outcomes identified in the main theme “I have acknowledged what's important in life,” where “a changed perspective,” “personal growth” and “the significance of close relationships” were important facets. The findings indicate that young adult cancer survivors need close and sustained follow up with screening and tailored interventions to minimize negative physical, emotional and social outcomes. In addition, actions that promote positive outcomes such as increasing social support, prioritizing close relationships and facilitating positive changes in values and life goals should be fostered during the entire cancer trajectory.

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Section: Discussionmentioning

confidence: 99%

“It's been a life‐changing experience!” A qualitative study of young adult cancer survivors’ experiences of the coexistence of negative and positive outcomes after cancer treatment

Hauken

Grue

Dyregrov

2019

Scandinavian J Psychology

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“…The National Comprehensive Cancer Network [2] defines cancer-related fatigue as "A distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning." In cancer survivors (patients who have completed cancer treatment as well as all patients who have been diagnosed with cancer), fatigue is a common symptom, and it reduces quality of life (QOL) [3][4][5]. Fatigue not only affects cancer survivors during treatment, but also affects 23-55% of survivors after treatment completion and can persist for months or even years [4,[6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The relation between mindfulness and the fatigue of women with breast cancer: path analysis

Ikeuchi

Ishiguro

Nakamura

et al. 2020

BioPsychoSocial Med

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Background: Although fatigue is a common and distressing symptom in cancer survivors, the mechanism of fatigue is not fully understood. Therefore, this study aims to investigate the relation between the fatigue and mindfulness of breast cancer survivors using anxiety, depression, pain, loneliness, and sleep disturbance as mediators.Methods: Path analysis was performed to examine direct and indirect associations between mindfulness and fatigue. Participants were breast cancer survivors who visited a breast surgery department at a university hospital in Japan for hormonal therapy or regular check-ups after treatment. The questionnaire measured cancer-relatedfatigue, mindfulness, anxiety, depression, pain, loneliness, and sleep disturbance. Demographic and clinical characteristics were collected from medical records.Results: Two-hundred and seventy-nine breast cancer survivors were registered, of which 259 answered the questionnaire. Ten respondents with incomplete questionnaire data were excluded, resulting in 249 participants for the analyses. Our final model fit the data well (goodness of fit index = .993; adjusted goodness of fit index = .966; comparative fit index = .999; root mean square error of approximation = .016). Mindfulness, anxiety, depression, pain, loneliness, and sleep disturbance were related to fatigue, and mindfulness had the most influence on fatigue (β = − .52). Mindfulness affected fatigue not only directly but also indirectly through anxiety, depression, pain, loneliness, and sleep disturbance.Conclusions: The study model helps to explain the process by which mindfulness affects fatigue. Our results suggest that mindfulness has both direct and indirect effects on the fatigue of breast cancer survivors and that mindfulness can be used to more effectively reduce their fatigue. It also suggests that health care professionals should be aware of factors such as anxiety, depression, pain, loneliness, and sleep disturbance in their care for fatigue of breast cancer survivors.

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“…Notably, breast cancer is a leading cause of morbidity and mortality in women around the world. [ 19 , 20 ] Doxorubicin and trastuzumab are the cornerstone regimen for breast cancer. However, many studies have shown the cardiotoxicity of these 2 medications.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of soluble ST-2 for changes of cardiac function and structure in breast cancer patients receiving chemotherapy

et al. 2018

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The current study was to evaluate soluble ST-2 level and left ventricular ejection fraction (LVEF) in patients with breast cancer receiving doxorubicin or trastuzumab treatment for 6 months and determine whether soluble ST-2 level can be used to predictive left ventricular function impairment.Patients who were diagnosed as having breast cancer receiving doxorubicin or trastuzumab or combined therapy were enrolled. Demographic data, prior medical history and related medical therapy, and site and stage of breast cancer information were collected from electronic health record. Fasting blood was used to detect soluble ST-2 and brain natriuretic peptide (BNP) levels before and after 6 months doxorubicin or trastuzumab therapy. Echocardiography was performed before and after 6 months of doxorubicin or trastuzumab therapy.Participants were divided into 3 groups based on tertiary soluble ST-2 level. Compared with 1st tertiary group, patients in the 3rd tertiary group had higher proportion receiving combined therapy (14.3% vs 4.7%, P < .05). Baseline soluble ST-2 level was similar across groups. After 6 months’ therapy, soluble ST-2 level was significantly higher in the 3rd tertiary group. Pearson correlation analysis showed that soluble ST-2 level was positively correlated with left ventricular volume and E/e’ ratio while negatively correlated with LVEF. Doxorubicin, trastuzumab, combined therapy, soluble ST-2 level, and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker treatment were all independently associated with LVEF change.In breast cancer patients receiving doxorubicin or trastuzumab therapy, soluble ST-2 level can be used to predict cardiac function and structure changes.

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The relationship of fatigue in breast cancer survivors with quality of life and factors to address in psychological interventions: A systematic review

Cited by 114 publications

References 86 publications

“It's been a life‐changing experience!” A qualitative study of young adult cancer survivors’ experiences of the coexistence of negative and positive outcomes after cancer treatment

“It's been a life‐changing experience!” A qualitative study of young adult cancer survivors’ experiences of the coexistence of negative and positive outcomes after cancer treatment

The relation between mindfulness and the fatigue of women with breast cancer: path analysis

Predictive value of soluble ST-2 for changes of cardiac function and structure in breast cancer patients receiving chemotherapy

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