Pharmacists at the Puskesmas have a role in monitoring and fostering the Rational Use of Drugs (POR) to prevent and overcome the problems in drug administration. The high irrational use of drugs and the bad consequences of resistance is one of the reasons why this research needs to be done. The purpose of this study was to determine the suitability of prescribing non-pneumonia ARI drugs with the National POR indicator at the Sleman District Health Center, Yogyakarta. This research uses observational descriptive research with cross-sectional design. The research data obtained from non-pneumonia ARI prescriptions for the period January-June 2020. Data were analyzed descriptively by calculating the percentage rationality of prescribing non-pneumonia ARI drugs and their conformity with the National POR indicator. The results showed that during the study period, patients who visited the Puskesmas were dominated by women (56.45%) and the age group was 26-45 years (26.57%). From 8 Puskesmas in Sleman Regency, only 3 Puskesmas (37.5%) with non-pneumonia ARI prescriptions in each month that met the National POR criteria. This study concludes that not all puskesmas in Sleman Regency, Yogyakarta that included in the study meet the rationality standard for prescribing non-pneumonia ARI by the National POR criteria