The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment

Козиолова, Н. А.; Chernyavina, A. I.

doi:10.15829/1560-4071-2020-3-3708

Russ J Cardiol

2020

DOI: 10.15829/1560-4071-2020-3-3708

|View full text |Cite

The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment

Н. А. Козиолова

A. I. Chernyavina

Abstract: Взаимосвязь полиморфизма генов с риском развития хронической сердечной недостаточности у больных гипертонической болезнью при высокой приверженности к лечениюКозиолова Н. А., Чернявина А. И.Цель. Определить риск развития хронической сердечной недостаточности (ХСН) у больных гипертонической болезнью (ГБ) при высокой приверженности к лечению в зависимости от концентрации N-терминального фрагмента предшественника мозгового натрийуретического пептида (NТ-proBNP) в крови и наличия полиморфизма некоторых генов. Мате… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Chronic heart failure associated genetic polymorphisms

Sveklina,

Shustov,

Kolyubaeva

et al. 2024

Bulletin of the Russian Military Medical Academy

View full text Add to dashboard Cite

The genetic associations between single-nucleotide polymorphisms of genes and chronic heart failure in phenotypically similar groups of patients were examined. The known information about single-nucleotide polymorphisms associated with the main pathogenetic links of chronic heart failure is systematized. Using electronic databases (PubMed, Web of Science, eLibrary), a search and synthesis of scientific works was conducted, followed by the formation of groups of genes homogeneous in their functionality (i.e., genes of the metabolic cascade, coagulation cascade, and neuroendocrine cascade). From 50 literary sources analyzed, 15 of the most specific genes were identified (ApoA1, ApoE, ApoC3, GNB3, FTO, PON-1, ET(A), EDNRA, F13, ITGB3, PAI-1, VEGF, ACE, AGT, AGTR1), contributing in metabolic processes, the hemostatic system, endothelial function, and regulation of the renin–angiotensin–aldosterone system and associated with the development of chronic heart failure. The most significant contribution of these genes in the development of regulatory and structural disorders characteristic of the pathogenetic phenotype of chronic heart failure has been proven. The results are ambiguous. Thus, in individuals who have a polymorphic gene variant in their genotype associated with the risk of developing a disease, the possibility of its manifestation is considerably higher; however, this does not confirm the development of the disease. Moreover, a correlation was noted between ejection fraction in patients with chronic heart failure and gene polymorphisms associated with renin–angiotensin–aldosterone system dysfunction and metabolic cascade. Chronic heart failure is a polygenic disease. Hence, this allows for further research into groups of coordinately functioning genes that are part of genetic regulatory networks, enabling a more complete understanding of the etiology and pathophysiological mechanisms of this nosology with the aim of subsequent early identification of individuals belonging to the risk group and the creation of a set of measures for individual prevention diseases. We believe that the development of chronic heart failure with low ejection fraction is primarily responsible for gene polymorphisms associated with disorders of the renin–angiotensin–aldosterone system and for the development of chronic heart failure with preserved ejection fraction — gene polymorphisms associated with metabolic cascade disorders.

show abstract

Chronic heart failure associated genetic polymorphisms

Sveklina,

Shustov,

Kolyubaeva

et al. 2024

Bulletin of the Russian Military Medical Academy

View full text Add to dashboard Cite

show abstract

Allelic variants of folate metabolism genes among students in Arctic Russia

Voronsova,

Vorobyeva,

Vorobyeva

et al. 2023

Ekologiya cheloveka (Human Ecology)

View full text Add to dashboard Cite

AIM: analysis of epidemiology of the spread of polymorphism of folate metabolism genes in various ethnic groups Russians and Indians living in the Arctic region of Russia. METHODS: epidemiological, prospective, cross-sectional population study was performed on a sample of ethnic Indians and Russians, natives of the Arkhangelsk region.RESULTS: A questionnaire survey of participants and a molecular genetic study of genes determining folate metabolism were conducted by real-time PCR. During the study, the participants were divided into two groups a group of Russian ethnos and a group of Indian ethnos. A comparative analysis of the frequencies of the spread of polymorphism of folate metabolism genes in the two studied groups was carried out. CONCLUSION: russian participants were more likely to carry the unfavorable allele T polymorphism rs1801133 of the MTHFR gene in comparison with the group of ethnic Indians, which indicates an increased risk of folate metabolism disorders in the group of Russian participants.

show abstract

Relationship between folate cycle genes polymorphisms and development of chronic heart failure in patients with hypertension and type 2 diabetes mellitus

Sveklina,

Kolyubaeva,

Shustov

et al. 2023

Arter. gipertenz.

View full text Add to dashboard Cite

Limited studies have been performed on the association of distorted folates metabolism genetic markers with progression of clinically manifesting chronic heart failure with preserved ejection fraction (CHF-pEF) in patients with arterial hypertension (HTN) and type 2 diabetes mellitus (DM2).Objective. To identify folate cycle genes polymorphisms in patients with HTN, DM2 and CHF-pEF.Design and methods. We have identified the occurrence frequency of several MTHFR genes polymorphisms: 677 C > T (rs1801133), MTHFR: 1298 A > C (rs1801131), MTR: 2756 A > G (rs1805087), MTRR: 66 A > G (rs1801394) in patients with CHF-pEF and DM2 (n = 52), chronic heart failure with reduced ejection fraction (CHF-rEF) and DM2 (n = 49) and control patients without CHF or DM2 (n = 66). Mean aged was 69,9 ± 10,1 years old.Results. In comparison to the controls, the CHF-pEF group showed higher frequencies of rs1801133: CHF-pEF group — 61,54 % vs. 28,57 % (odds ratio (OR) — 4,0, confidence interval (CI) — 1,788–8,948, p < 0,002); rs1805087–75,0 % vs. 25,0 % (OR — 9,0, CI — 3,573–22,673, p < 0,001), rs1801394–90,38 % vs. 69,39 % (OR — 4,2, CI — 1,375–12,510, p < 0,017). Compared to the CHF-rFV group, the following frequencies were found: CHF-rFV — rs1805087–75,0 % against 36,96 % (OR — 5,2, CI — 2,110–12,414, p < 0,001), rs1801394–90,38 % vs. 68,75 % (OR — 4,3, CI — 1,414–12,909, p < 0,011). The polymorphism frequencies in CHF-rFV were generally comparable with such of the controls. Conclusions. Higher frequencies of rs1801133, rs1805087 and rs1801394 polymorphisms were detected in patients with HTN, DM2 and those with CHF-pEF, as compared to either helthy patients and those with reduced ejection fraction. There is also high rate of rs1801394 polymorphism in patients with HTN, DM2, regardless of the ejection fraction.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The relationship of gene polymorphism with the heart failure risk in patients with hypertension and high adherence to treatment

Cited by 3 publications

References 13 publications

Chronic heart failure associated genetic polymorphisms

Chronic heart failure associated genetic polymorphisms

Allelic variants of folate metabolism genes among students in Arctic Russia

Relationship between folate cycle genes polymorphisms and development of chronic heart failure in patients with hypertension and type 2 diabetes mellitus

Contact Info

Product

Resources

About