The relationship of intestinal fat to an augmented acid and gastrin response in dogs with a reversible pancreatic fistula

Hofmann, James W.; Raih, T.J.; Go, Vay Liang W.; Wilson, Stuart D.

doi:10.1016/0022-4804(75)90102-x

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…Similarly, Kyle and Welbourn (1966) reported that the administration of fat after PDL accelerated acid secretion from the Heidenhain pouch, but this was suppressed when pancreatic juice was administered simultaneously. Hofmann et al (1975) found that instillation of olive oil and oleic acid into the duodenum in the presence of pancreatic juice could inhibit gastric acid secretion, but in the absence of pancreatic juice, the inhibitory effect was only recognized with the instillation of oleic acid. Sakazaki et al (1976), however, contended that only lack of lipase in pancreatic juice or pancreatic atrophy is not enough for full explanation of gastric hypersecretion after PDL.…”

Section: Discussionmentioning

confidence: 99%

Influence of pancreatic duct ligation on gastric acid secretion.

Sekine

Kameyama

Sasaki

et al. 1981

Tohoku J. Exp. Med.

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The influence of pancreatic duct ligation (PDL) on gastric secretion was investigated in dogs with a Heidenhain pouch. A test meal was given to the dogs before PDL, and following PDL the dogs were administered with the test meal mixed with pancreatic enzymes and with the test meal alone in succession. The responses to the test meal were examined in the control period and every one week for a period of 1 to 6 weeks following PDL to identify the changes in gastric acid secretion, serum gastrin levels, immunoreactive glucagon (IRG) levels and immunoreactive insulin (IRI) levels. Gastric acid secretion in response to food stimulations markedly increased after PDL. However, the acid secretion was significantly inhibited by the administration of pancreatic enzymes. Serum gastrin levels began to increase from the second week and continued to increase until the sixth week after PDL, revealing no effect of pancreatic enzymes. IRG levels also increased following PDL, particularly in cases administered with pancreatic enzymes. IRI levels were higher at the first week of PDL than before PDL, but tended to decrease thereafter. It is assumed that gastric hypersecretion after PDL would have complicated relations with IRG, gastric inhibitory polypeptide (GIP) as well as with antral gastrin. pancreatic duct ligation; pancreatic enzymes; gastric acid secretion; serum gastrin level; immunoreactive glucagon level Complications of peptic ulcer in patients with chronic pancreatitis have so far been noted (Elliott et al. 1964;Elliott 1974), and it has been experimentally pointed out that gastric hypersecretion and ulcers are likely to develop following pancreatic duct ligation (Yesko 1928;Elliott et al. 1963; Hemn et al. 1963;Kyle and Welbourn 1966;Peterson et al. 1974), external pancreatic fistulae (Greenlee et al. 1959), and total pancreatectomy (Barcena et al. 1956). However, its mechanism still remains obscure. With an aim to clarify the influence of pancreatic duct ligation on gastric acid secretion, the present study was undetaken. We ligated the pancreatic ducts in dogs with a Heidenhain pouch and studied their responses to food stimulation, i.e., changes in gastric acid secretion, serum gastrin levels, immunoreactive glucagon (IRG) levels and immunoreactive insulin (IRI) levels. A particular attention was paid on the effect of the administration of pancreatic enzymes.

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Section: Discussionmentioning

confidence: 99%

Influence of pancreatic duct ligation on gastric acid secretion.

Sekine

Kameyama

Sasaki

et al. 1981

Tohoku J. Exp. Med.

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“…In part, the hypersecre tion is the result of defective gastric inhibition from the small intestine. Nor mally, the products of the digestion of fat inhibit gastric secretion, but since digestion of fat is defective in pancreatic insufficiency, so is fat-evoked gastric inhibition (6). In addition, pancreatic insufficiency may result in abnormal stimulation of gastric secretion.…”

Section: Discussionmentioning

confidence: 99%

Gastric Secretion of Acid in Patients with Pancreatic Disease

Saunders

Cargill

Wormsley³

1978

Digestion

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In view of the destruction of pancreatic extract, used in the treatment of pancreatic insufficiency, by gastric juice, we measured the gastric secretory response to pentagastrin in patients with pancreatic disease. The patients with chronic pancreatitis and steatorrhoea secreted as much acid as patients with duodenal ulcer, emphasising the need for therapeutic gastric secretory inhibition to supplement treatment of pancreatic insufficiency with pancreatic extract.

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A modified version of Herrera's method for creating a pancreatic fistula in dogs

Nishiwaki

Satake

Umeyama

1990

The Japanese Journal of Surgery

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Various cannulae have been devised to serve in experiments for collecting pancreatic juice. In this study we created a pancreatic fistula in dogs through a modification of Herrera's method. Since it is advisable to make as small a duodenal pouch as possible to collect almost all the secreted pancreatic juice, both ends of the pouch were closed by an inverted continuous all-layer suture. The lateral flange of the cannula was then introduced into the pouch to sample the pancreatic juice. Duodenoduodenostomy was performed to restore continuity of the alimentary tract, and the other end was inserted into the duodenum 3 cm distal to the anastomosis on the anal side. The exocrine pancreatic secretion of these dogs responded well to food ingestion, with a peak level of 14.5 +/- 5.4 ml/15 min appearing after 30 to 45 min in a postprandial state. Moreover, the animals were able to survive and be utilized for experiments for a period of 3 to 5 months. This experimental model is therefore considered to be of great value for the investigation of exocrine pancreatic secretion.

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The relationship of intestinal fat to an augmented acid and gastrin response in dogs with a reversible pancreatic fistula

Cited by 8 publications

References 17 publications

Influence of pancreatic duct ligation on gastric acid secretion.

Influence of pancreatic duct ligation on gastric acid secretion.

Gastric Secretion of Acid in Patients with Pancreatic Disease

A modified version of Herrera's method for creating a pancreatic fistula in dogs

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