The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis

Sertpoyraz, Filiz Meryem

doi:10.14744/nci.2020.23590

Cited by 6 publications

(18 citation statements)

References 30 publications

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“…A major finding of the present study was that patients with AS had significantly higher serum IMA level than controls. This finding is in agreement with the findings of a previous study that compared the serum IMA level between 63 patients with AS and 48 controls and found that the AS patients had significantly higher IMA levels than controls [27].…”

Section: Discussionsupporting

confidence: 93%

“…In the study of Sertpoyraz et al the CRP and IMA levels were high in patients with active AS, and there was a positive correlation between them [45]. Consistent with these findings, it was previously found that high CRP values were associated with radiological changes and SIj inflammation and correlated with the BASDAI scores [46].…”

Section: Discussionsupporting

confidence: 53%

“…Among patients with Behcet's disease, the IMA levels were found to increase in those with active disease and vascular involvement [48].In agreement with the findings of the present study, Sertpoyraz et al found that the IMA and CRP levels in the patients with active AS were higher than those with inactive AS. In patients with AS, the IMA levels had a positive correlation with the disease activity criteria, BASDAI and CRP [27].…”

Section: Discussionmentioning

confidence: 89%

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the serum ischemia modified albumin in patients with ankylosing spondylitis

mohamed,

el-bassiouny,

El-kady

et al. 2023

Zagazig University Medical Journal

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Background: Ankylosing spondylitis (AS) is a chronic, inflammatory disease that primarily affects the axial spine. Involvement of the sacroiliac joint is a hallmark of AS. AS is also associated with an increased risk of CVD (cardiovascular disease) which constitutes one of the main causes of death in these patients. AS is a complex immune-mediated condition whose pathogenesis is not fully understood. It is assumed that Reactive oxygen species is a major event in inflamed tissues leading to AS. Albumin acts as an antioxidant by removing oxidative stress products. Ischemia modified albumin (IMA) had gained wide acceptance as a systemic biomarker of oxidative stress. The aim of study to evaluate the serum level of ischemiamodified albumin in patients with ankylosing spondylitis and to correlate the ischemia-modified albumin serum level with disease activity indices, and carotid artery intima media thickness. Objective: The aim of the study was to evaluate the serum level of IMA in patients with AS and to correlate the IMA serum level with disease activity indices, and Carotid intima media thickness. Subjects and Methods: This cross-sectional study included 40 AS patients and 40 matched healthy controls. In AS patients, the activity parameters (BASDAI score, ASDAS-ESR, ASDAS-CRP, ESR and serum CRP levels) as well as BASFI score and BASMI score and treatment regimen were assessed. In addition, the cIMT and was measured for AS patients and controls. Ischemia-modified albumin (IMA) was also measured. Results: Patients with AS had significantly higher serum IMA level than controls. The ROC curve analysis revealed a strong ability of the IMA to discriminate the AS patients from controls. In AS patients, the serum IMA was significantly correlated with the cIMT and was higher in AS patients with plaques than those without plaques. Conclusion: our study has shown that the serum level of IMA was significantly higher in patients with AS than matched healthy controls. MA serum level was significantly correlated with AS activity and severity. Serum IMA can be used as a marker for subclinical atherosclerosis in AS.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 89%

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the serum ischemia modified albumin in patients with ankylosing spondylitis

mohamed,

el-bassiouny,

El-kady

et al. 2023

Zagazig University Medical Journal

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“…In many studies, it has been shown that serum IMA level is higher than HC in rheumatological diseases such as RA and AS and is associated with disease activity. [40][41][42][43] In our study, serum IMA levels were found to be similar between SLE patients and HCs. But serum IMA levels were found to be higher in SLE patients with HDA compared to LDA.…”

Section: Discussionmentioning

confidence: 70%

Evaluation of thiol/disulfide hemostasis and serum Ischemia modified albumin as oxidative stress biomarkers in systemic lupus erythematosus patients: Relationship with major organ involvement and disease activity

Ermurat

Kazancı

Toka

et al. 2022

Lupus

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Objectives We aimed to compare thiol/disulfide hemostasis and serum ischemia-modified albumin (IMA) levels, which are indicators of oxidative stress (OS), in patients with systemic lupus erythematosus (SLE), with the healthy control (HC) group and to evaluate the relationship of these parameters with disease activity and major organ involvement. Material-Methods Eighty-four SLE patients and 96 HCs were included in this study. The disease activity of SLE patients was calculated using The Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). Patients with SLEDAI-2K ≤ 5 were classified as low disease activity (LDA) and those with SLEDAI-2K > 6 as high disease activity (HDA). Thiol/disulfide hemostasis was evaluated using a new automated method and natural thiol (NT), total thiol (TT), disulfide (SS) levels, SS/NT, SS/TT, NT/TT ratios, and serum IMA levels were recorded. Results NT and TT levels were significantly lower (490.11 ± 123.61 vs 536.96 ± 86.05, p = 0.003) (532.56 ± 125.80 vs 565.72 ± 89.82, p = 0.046), SS level (21.22 ± 11.75 vs 13.37 ± 9.31, p < 0.001) was higher, and SS/TT (4.64 ± 2.93 vs 2.52 ± 1.82, p < 0.001) and SS/NT (4.12 ± 2.33 vs 2.35 ± 1.59, p < 0.001) ratios were significantly higher in SLE patients compared to HCs. IMA values were not different between the two groups ( p = 0.920). NT (449.84 ± 136.98 vs 520.32 ± 104.11, p = 0.012) and TT levels (492.01 ± 138.45±562.97 ± 107.09, p = 0.013) were significantly lower and serum IMA levels (0.802 ± 0.089 vs 0.764 ± 0.040, p = 0.023) were significantly higher in SLE patients with HDA than in LDA patients. There was a weak negative correlation between NT (r = −0.284, p=0.009) (r = −0.291, p = 0.007) and TT levels (r = −0.281, p = 0.010) (r = −0.289, p = 0.008) and a weak positive correlation between IMA levels (r = 0.279, p = 0.011) (r = 0.263, p = 0.016) and SLEDAI-2K, and major organ involvement. Conclusion It is thought that thiol/disulfide hemostasis and IMA levels may be used as ideal biomarkers of OS in SLE patients and may reflect the disease activity and major organ involvement.

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“…In addition, ischemia-modified Alb (IMA) is a type of Alb with an altered structural conformation of the N-terminus of Alb that increases upon exposure to ischemia, hypoxia, oxidative stress, and inflammation [ 8 ]. Although IMA was initially recognized as a biological marker increased in acute coronary syndrome, research has demonstrated that IMA is also elevated in patients with autoimmune disorders such as inflammatory bowel diseases, Behcet disease, and ankylosing spondylitis [ 9 – 11 ]. Nonetheless, the correlation between disease activity and indices of Alb, Palb, and IMA has not been investigated in patients with AAV.…”

Section: Introductionmentioning

confidence: 99%

Serum albumin, prealbumin, and ischemia-modified albumin levels in patients with ANCA-associated vasculitis: A prospective cohort study

et al. 2022

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Objectives Acute phase reactants (APRs) are proteins altered by inflammation and are regarded as surrogate markers representing inflammatory status. This study evaluated changes of albumin (Alb), prealbumin (Palb), and ischemia-modified albumin (IMA) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in response to alterations in disease activity and the correlation between disease activity and Alb, Palb, and IMA. Methods Fifty-nine patients with AAV registered in the prospective SHAVE cohort, who had available serial blood samples at least three months apart were included (indicated as pre and post). Correlation analysis and linear regression were carried out to determine the relationship between continuous variables. Alb, Palb, and IMA levels in 40 healthy controls (HCs) were compared with patients with AAV. Results Comparison of Alb, Palb, and IMA levels in HCs and in patients at initial (pre) and follow-up (post) time points revealed that Alb levels significantly increased following the improvement of disease activity and were comparable between HCs and patients at follow-up (post). Meanwhile, there was no significant difference noted in Palb and IMA levels after the decrease of disease activity. While initial (pre) Alb and Palb were significantly associated with BVAS, a subgroup analysis of patients with new-onset disease showed Palb was no longer significantly associated with Birmingham Vasculitis Activity Score (BVAS). Multivariate linear regression showed Alb level (standardized β = -0.377; 95% confidence interval: -5.623, -1.260; p = 0.003) was an independent predictor of BVAS at baseline. Conclusions Among Alb, Palb, and IMA, we found that Alb could be a useful marker indicating disease activity in patients with AAV.

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The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis

Cited by 6 publications

References 30 publications

the serum ischemia modified albumin in patients with ankylosing spondylitis

the serum ischemia modified albumin in patients with ankylosing spondylitis

Evaluation of thiol/disulfide hemostasis and serum Ischemia modified albumin as oxidative stress biomarkers in systemic lupus erythematosus patients: Relationship with major organ involvement and disease activity

Serum albumin, prealbumin, and ischemia-modified albumin levels in patients with ANCA-associated vasculitis: A prospective cohort study

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