The relationship of metalloproteinase gene polymorphisms and lung cancer

Şanlı, Maruf; Akar, Erkan; Pehlıvan, Sacide; Bakir, Kemal; Tunçözgür, Bülent; Işık, Ahmet Feridun; Pehlıvan, Mustafa; Elbeyli, Levent

doi:10.1016/j.jss.2013.01.045

Cited by 19 publications

(17 citation statements)

References 19 publications

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“…Recently, it has been shown that MMPs play significant roles in tumor initiation and development. 17Y19 It has been demonstrated that polymorphisms of some MMPs were strongly associated with a risk of cancer, such as prostate cancer, 20 breast cancer, 21,22 lung cancer, 23,24 and bladder cancer. 25,26 It has been reported that the matrix metalloproteinase-1 (MMP1) promoter j1607Ybase pair (bp) polymorphism was a negative prognostic parameter in patients with ovarian cancer.…”

mentioning

confidence: 99%

Analysis of the Association of Matrix Metalloproteinase-1 Gene Promoter (rs1799750) Polymorphism and Risk of Ovarian Cancer

Wang

Kong

2015

Int J Gynecol Cancer

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confidence: 99%

Analysis of the Association of Matrix Metalloproteinase-1 Gene Promoter (rs1799750) Polymorphism and Risk of Ovarian Cancer

Wang

Kong

2015

Int J Gynecol Cancer

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“…In general, extracellular MMP-13 breaks down collagens and has been shown to be an important biomarker for breast and other types of cancers. 22–26 However, after cerebral ischemia, the MMP-13 was found to be localized in the nucleus of neural cells. 22 This nuclear translocation was associated with oxygen and glucose deprivation of the cells undergoing ischemia.…”

Section: Nuclear Mmps Induce Apoptosismentioning

confidence: 99%

“…Studies have shown that overexpression of MMP-13 plays a role in the metastasis of colon cancer, breast and other cancer types. 24–27 , 31–33 For instance, disruption of basement membranes of tissues by upregulated MMP-13 leads to cell dissociation, tumor invasion and metastasis in breast cancer. 33 MMP-10 was known to induce cell invasion in cervical tumors.…”

Section: Nuclear Mmps In Cell Migrationmentioning

confidence: 99%

Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment

et al. 2017

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Matrix metalloproteinase (MMP) is defined as an endopeptidase in the extracellular matrix (ECM), which plays essential roles in physiological processes such as organogenesis, wound healing, angiogenesis, apoptosis and motility. MMPs are produced and assembled in the cytoplasm as proenzymes with a cytoplasmic domain and require extracellular activation. MMPs can degrade receptors, extracellular matrix proteins, PARPs and release apoptotic substances. MMPs have been found in the cytosol, organelles and extracellular compartments and recently many types of MMPs have been found in the nucleus. However, the mechanisms and roles of MMPs inside the cell nucleus are still poorly understood. Here we summarized the nuclear localization mechanisms of MMPs and their functions in the nucleus such as apoptosis, tissue remodeling upon injury and cancer progression. Most importantly, we found that nuclear MMPs have evolved to translocate to membrane and target ECM possibly through evolution of nuclear localization signal (NLS), natural selection and anti-apoptotic survival. Thus, the knowledge about the evolution and regulation of nuclear MMPs appears to be essential in understanding a variety of cellular processes along with the development of MMP-targeted therapeutic drugs against the progression of certain diseases.

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“…Matrix metalloproteinase 13 (MMP-13 and also known as collagenase 3) is a zinc-dependent protease and has been shown as a potential biomarker for breast and other cancer. [1][2][3][4] Also, it has long been considered as a target in the treatment of osteoarthritis (OA), and rheumatoid arthritis (RA). 5,6) Recently, its role in tumor metastasis has been reported first in colon carcinomas 7) and later in breast and other cancer.…”

mentioning

confidence: 99%

“…5,6) Recently, its role in tumor metastasis has been reported first in colon carcinomas 7) and later in breast and other cancer. [1][2][3][4] MMP activities can be regulated by tissue inhibitors of metalloproteinases (TIMPs). 8) The increased levels of MMP-13 result in an imbalance, in spite of TIMPs, thus resulting in a diseased state.…”

mentioning

confidence: 99%

Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) – experimental validation in human breast and colon cancer

Kothapalli

Siveen

Tan

et al. 2016

Bioscience, Biotechnology, and Biochemistry

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Considering the pathological significance of MMP-13 in breast and colon cancers, exosite-based inhibition of the C-terminal hemopexin (Hpx) domain could serve as an alternative strategy to develop selective inhibitors for MMP-13.Two of six lead compounds, compound 5 (2,3-dihydro-1,4-benzodioxine-5-carboxylic acid) and compound 6 (1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid) exhibited considerable inhibitory activity against MMP-13. Complementing to this study, we have also shown the gene expression levels of MMP-13 within the subtypes of colon and breast cancers classified from patients' tissue samples to provide a better understanding on which subtype of breast cancer patients would get benefited by MMP-13 inhibitors.Our current results show that compounds 5 and 6 could effectively inhibit MMP-13 and provide specific therapeutic possibilities in the treatment of inflammatory disorders and cancers. The characterization of these lead compounds would provide a better mechanistic understanding of exosite-based inhibition of MMP-13, which could overcome the challenges in the identification of other MMP catalytic domain-specific inhibitors.

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The relationship of metalloproteinase gene polymorphisms and lung cancer

Cited by 19 publications

References 19 publications

Analysis of the Association of Matrix Metalloproteinase-1 Gene Promoter (rs1799750) Polymorphism and Risk of Ovarian Cancer

Analysis of the Association of Matrix Metalloproteinase-1 Gene Promoter (rs1799750) Polymorphism and Risk of Ovarian Cancer

Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment

Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) – experimental validation in human breast and colon cancer

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