The relationship of montreal cognitive assessment scores to framingham coronary and stroke risk scores

Abstract

We examined the relationship between a brief cognitive screening measure and Framingham Coronary and Stroke Risk scores. We administered the Montreal Cognitive Assessment (MoCA) to participants in the Dallas Heart Study, a community-based multiethnic study investigating the development of atherosclerosis. The composition of the group was 50% African American, 36% Caucasian and 14% Hispanic. There were 765 subjects (mean age 51 years) who had both Coronary and Stroke Risk scores and an additional 144 subjects with only Coronary Risk scores available. There was a small significant inverse relationship between MoCA and Framingham Coronary and Stroke Risk scores. MoCA scores were influenced by education, but were not influenced by age or by the presence of one or more apoE4 alleles.

Cognitive Assessment in Asymptomatic COVID-19 Subjects

“…Cognitive decline was also detected in subjects with TIA or first ever stroke if they had more than two vascular risk factors or low cerebral perfusion on transcranial Doppler ultrasound (134,135). MoCA also correlated with the Framingham coronary and stoke risk scores (136).…”

Pro-Inflammatory Substances and Cognition in the Dallas Heart Study

“…There was a modest relationship between CRP and MoCA scores but no significant relationships between levels of MCP-1, IL-18 and cognition. Lack of significant correlations between MoCA scores and proinflammatory substance concentration in blood was surprising, in that we had previously reported a modest relationship between Framingham Coronary and Stroke scores in the same relatively young group of subjects [29]. However, other studies had also failed to find such associations, suggesting that inflammatory markers, at least in healthy samples, were not useful predictors of cognitive function [6].…”