The relationship of N2 and P3 to inhibitory processing of social drinkers in a Go/NoGo task

Oddy, Bruce W.; Barry, Robert J.

doi:10.1016/j.ijpsycho.2009.02.002

Cited by 34 publications

(35 citation statements)

References 48 publications

(66 reference statements)

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“…Moreover, in line with the lack of inhibition observed following chronic alcohol consumption using behavioral tasks (Fillmore, 2003;Noël et al, 2010), several studies have found smaller P300 amplitude during No-go trials in alcohol-dependent patients (Cohen et al, 1997;Kamarajan et al, 2005). Similar to alcohol-dependent patients, heavy social drinkers exhibit a reduction of the No-go P300 amplitude compared to light drinkers (Oddy and Barry, 2009). Lack of inhibitory skills have also been associated with compensatory neuronal mechanisms allowing drinkers to achieve performance levels similar to those in controls with increased No-go P3 amplitude and higher prefrontal activation in binge drinkers, as compared to controls, when successful inhibition responses were analyzed (López-Caneda et al, 2012).…”

Section: Introductionmentioning

confidence: 75%

“…Several discrepancies between the two studies could explain the absence of difference in our study. Firstly, in the study of Oddy and Barry (2009), the level of alcohol consumption was based on the number of standard alcoholic drinks per month. Here, heavy and light drinkers were classified according to the AUDIT scores.…”

Section: Discussionmentioning

confidence: 99%

“…For the letter Go/No-go task, the percentage of FA on No-go trials and the average reaction times (RT) on Go trials of the two groups (heavy and light drinkers) were analyzed with Student's t-test. N200 and P300 amplitudes and latencies were analyzed with four separate three-way mixed ANOVAs including Group (heavy vs. light drinkers), Trial type (Go and No-go) and Electrodes (F3-Fz-F4-C3-Cz-C4-Pz; Oddy and Barry, 2009;Petit et al, 2012a) as factors, with Trial type and Electrode as within-subject variables.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…The average percentage of FA on No-go trials and the average RT on Go trials were analyzed with three-way mixed ANOVAs including Stimulus type (alcohol-related vs. neutral picture) as within subject factor and Group (heavy vs. light drinker) and Alcohol avoidance (high alcohol avoiders and low alcohol) as between subject factors. Five-way mixed ANOVAs with Group (heavy vs. light drinkers), Alcohol avoidance (high alcohol vs. low alcohol avoiders), Stimulus type (alcohol-related vs. neutral picture), Trial type (Go and No-go), and Electrode (F3-Fz-F4-C3-Cz-C4-Pz; Oddy and Barry, 2009;Petit et al, 2012a) were conducted separately with N200 and P300 amplitudes and latencies as dependent variables.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…However, two studies did not observe such a deficit in heavy social drinkers (Adams et al, 2013;Nederkoorn et al, 2009), whereas detoxified alcohol-dependent patients showed impaired response inhibition towards alcohol-related cues after 19.7 (±2.7) days of abstinence (Noël et al, 2007). However, several ERP studies revealed early cerebral dysfunctions related to alcohol consumption before any detectable behavioral impairment in social drinkers (Bijl et al, 2005;Nichols and Martin, 1996;Oddy and Barry, 2009), and in binge drinkers (López-Caneda et al, 2013Maurage et al, 2009Maurage et al, , 2012Watson et al, 2014). To our knowledge, only one electrophysiological study assessed the inhibition abilities toward alcohol-related information (Petit et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

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Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: Impact of alcohol avoidance

Kreusch

Quertemont

Vilenne

et al. 2014

International Journal of Psychophysiology

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a b s t r a c t a r t i c l e i n f oAlcohol addictive behaviors are associated with a combination of deficits in executive functions, such as a weak response inhibition, and potent automatic appetitive responses to alcohol-related cues. The aim of the present study was to investigate behavioral responses and event-related potentials (ERPs) associated with specific response inhibition for alcohol-related cues. Thirty participants (15 heavy drinkers and 15 light drinkers) took part in the study. Response inhibition was assessed by a classical letter Go/No-go task and by a modified alcohol Go/No-go task. Participants were also classified as high and low alcohol avoiders. Results showed that heavy drinkers made more false alarms in the letter Go/No-go task. In the alcohol Go/No-go task, an absence of N200 amplitude anteriorization was found in heavy drinkers as compared to light drinkers. Participants with a high level of alcohol avoidance exhibited more false alarms, and higher N200 amplitude for the No-go trials as compared to the Go trials for alcohol-related cues. Higher P300 amplitude was observed in low alcohol avoiders for No-go as compared to Go trials. Therefore, a context involving alcohol-related cues disturbed inhibition capacities of high alcohol avoiders. These results suggest that the level of alcohol avoidance must be taken into account in studies investigating alcohol-related cognitive biases.

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Section: Introductionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: Impact of alcohol avoidance

Kreusch

Quertemont

Vilenne

et al. 2014

International Journal of Psychophysiology

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Effects of binge drinking on action cascading processes: an EEG study

2013

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High-dosage alcohol intoxication (i.e., binge drinking in humans) is an increasingly prevalent problem. Despite the well-known long-term consequences, the acute effects of high-dosage alcohol intoxication on cognitive control processes have not been investigated with respect to neurophysiological changes in humans. We provide insights into the effects of high-dosage ethanol intoxication on action control functions in humans on the basis of neurophysiological (EEG) data. Action control processes were examined in a stop-change task. Based on a detailed analysis of behavioral and electrophysiological data, we demonstrate a specific modulation of action cascading processes. Opposed to commonly held views, high-dosage ethanol intoxication (0.9-1.13 ‰) exerts highly specific effects on cognitive subprocesses mediating action control. If action control processes are performed in succession, intoxicated and non-intoxicated participants perform equally well. However, action control processes become compromised during high-dosage ethanol intoxication, when different response options require processing resources in parallel. Under high-dose ethanol intoxication, subjects are not able to prioritize different response options. We could demonstrate that the effects were of high effect sizes (η (2) = 0.702) and rely more on response selection deficits than on deficits in attentional processing. The changes in response selection processes are mediated via the anterior cingulate cortex. The specificity of the observed effects may be due to a differential involvement of dopaminergic and GABAergic processes in action control and attentional selection processes.

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Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects

et al. 2010

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RationaleThe NOGO P3 event-related potential is a sensitive marker of alcoholism, relates to EEG oscillation in the δ and θ frequency ranges, and reflects activation of an inhibitory processing network. Degradation of white matter tracts related to age or alcoholism should negatively affect the oscillatory activity within the network.ObjectiveThis study aims to evaluate the effect of alcoholism and age on δ and θ oscillations and the relationship between these oscillations and measures of white matter microstructural integrity.MethodsData from ten long-term alcoholics to 25 nonalcoholic controls were used to derive P3 from Fz, Cz, and Pz using a visual GO/NOGO protocol. Total power and across trial phase synchrony measures were calculated for δ and θ frequencies. DTI, 1.5 T, data formed the basis of quantitative fiber tracking in the left and right cingulate bundles and the genu and splenium of the corpus callosum. Fractional anisotropy and diffusivity (λL and λT) measures were calculated from each tract.ResultsNOGO P3 amplitude and δ power at Cz were smaller in alcoholics than controls. Lower δ total power was related to higher λT in the left and right cingulate bundles. GO P3 amplitude was lower and GO P3 latency was longer with advancing age, but none of the time–frequency analysis measures displayed significant age or diagnosis effects.ConclusionsThe relation of δ total power at CZ with λT in the cingulate bundles provides correlational evidence for a functional role of fronto-parietal white matter tracts in inhibitory processing.

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The relationship of N2 and P3 to inhibitory processing of social drinkers in a Go/NoGo task

Cited by 34 publications

References 48 publications

Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: Impact of alcohol avoidance

Alcohol abuse and ERP components in Go/No-go tasks using alcohol-related stimuli: Impact of alcohol avoidance

Effects of binge drinking on action cascading processes: an EEG study

Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects

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