The Relationship of Nasal Polyps, Infection, and Inflammation

Norlander, Tomas; Brönnegård, Mikael; Stierna, Pontus

doi:10.2500/105065899781367537

Cited by 37 publications

(32 citation statements)

References 28 publications

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“…Segundo Norlander et al 2 , 1999, há um considerável incremento de mediadores inflamatórios na submucosa do pólipo e mucosa adjacente. Os efeitos combinados de citocinas e fatores de crescimento produzidos por linfócitos T, fibroblastos, células epiteliais e células circulantes, principalmente eosinófilos, podem ser responsáveis pelas diversas fases do processo de formação do pólipo.…”

Section: Introdução Introdução Introdução Introdução Introduçãounclassified

Polipose nasossinusal: doença inflamatória crônica evolutiva?

Souza

Serra

Dorgam

et al. 2003

Rev. Bras. Otorrinolaringol.

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INTRODUÇÃO: A polipose nasossinusal é uma doença degenerativa da mucosa onde há formação de múltiplas estruturas polipóides nas cavidades nasais e seios paranasais e cujos mecanismos fisiopatológicos ainda não são bem compreendidos. FORMA DE ESTUDO: Clínico prospectivo. OBJETIVO E MATERIAL e MÉTODO: Objetivando colaborar na compreensão dos fatores envolvidos na patogênese dos pólipos nasais, decidimos estudar a histologia e a ultraestrutura dos pólipos em dezessete pacientes portadores de polipose. Os pacientes foram divididos em 2 grupos: alérgicos (5 pacientes) e não alérgicos (12 pacientes). RESULTADOS: Mucosa respiratória normal cobrindo a superfície do epitélio foi encontrada em oito casos; metaplasia escamosa em quatro casos; diferentes tipos epiteliais em três casos; epitélio respiratório atípico em um caso e ausência de mucosa em um caso. Foram observados quatorze casos de pólipo tipo fibro-inflamatório, um caso de hiperplasia de glândulas seromucinosas e dois casos de pólipos fibróticos. CONCLUSÕES: Os pacientes apresentaram índices de testes cutâneos positivos iguais ou maiores que a população geral, entretanto, não houve diferenças histológicas ou ultraestruturais entre os pólipos de pacientes alérgicos e dos não alérgicos, sugerindo ser a alergia um fator contribuinte mas não causal na fisiopatologia da polipose nasossinusal.

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Section: Introdução Introdução Introdução Introdução Introduçãounclassified

Polipose nasossinusal: doença inflamatória crônica evolutiva?

Souza

Serra

Dorgam

et al. 2003

Rev. Bras. Otorrinolaringol.

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“…Clinical as well as experimental studies indicate that nasal polyp formation and growth are activated and perpetuated by an integrated process of mucosal epithelium and matrix and inflammatory cells, which in turn may be initiated by both infectious and noninfectious inflammations (23). Experimental models in which multiple epithelial disruptions with proliferating granulation tissue have been initiated by bacterial infection with Streptococcus pneumoniae, Staphylococcus aureus, Bacteroides fragilis (all common pathogens in sinusitis), or Pseudomonas aeruginosa (24) have been described previously.…”

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confidence: 99%

Antifungal Immune Reactivity in Nasal Polyposis

et al. 2004

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As a fungal etiology has been proposed to underlie severe nasal polyposis, the present study was undertaken to assess local antifungal immune reactivity in nasal polyposis. For this purpose, microbial colonization, along with the pattern of T helper 1 (Th1)/Th2 cytokine production and Toll-like receptor (TLR) expression, was evaluated in patients with nasal symptoms and with and without polyposis and in healthy subjects. The results show that Th2 reactivity was a common finding for patients with nasal polyposis regardless of the presence of microbes. The production of interleukin-10 was elevated in patients with bacterial and, particularly, fungal colonization, while both TLR2 expression and TLR4 expression were locally impaired in microbe-colonized patients. Eosinophils and neutrophils, highly recruited in nasal polyposis, were found to exert potent antifungal effector activities toward conidia and hyphae of the fungus and to be positively regulated by TLR2 or TLR4 stimulation. Therefore, a local imbalance between activating and deactivating signals to effector cells may likely contribute to fungal pathogenicity and the expression of local immune reactivity in nasal polyposis.

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“…The pathogenesis of nasal polyps is probably multifactorial (2). This clinical condition can be associated with systemic diseases of the respiratory tract such as asthma, rhinitis, aspirin-intolerance, cystic fibrosis or primary cilia dyskinesia, or with more localized diseases such as chronic sinusitis with a dental or fungal focus of infection/ inflammation (3).…”

Section: Introductionmentioning

confidence: 99%

Gene expression analysis reveals novel altered genes in nasal polyps

Babeto

Calmon²,

Provazzi³

et al. 2010

Mol Med Rep

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Abstract. Nasal polyposis (NP) is a chronic inflammatory disease of the nasal mucosa characterized by the infiltration of inflammatory cells, mainly eosinophils. Although nasal polyposis occurs in 4% of the population, its physiopathology remains unclear. The aim of this study was to identify and characterize differentially expressed genes that can be used in the prognosis, treatment and elucidation of this physiopathology. To identify novel genes differentially expressed in NP, we applied real-time quantitative PCR to 11 NP samples and to a pool of total RNA from a subset of 13 normal nasal mucosa samples from human autopsies. For selecting genes, the methylated CpG island amplification technique was used. Five differentially methylated clones (ATP2A1, NOVA1, PLCD3, SOLH and TGFβI) were identified. However, these genes presented methylated CpG islands between exons, i.e., not in the promoter regions of the genes. Thus, as shown by real-time PCR, the ATP2A1, SOLH, PLDC3 and TGFβI genes were overexpressed in NP. The genes identified in this study are probably involved in some stage of the process of formation and development of nasal polyposis, as they were highly expressed in the nasal polyp samples.

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The Relationship of Nasal Polyps, Infection, and Inflammation

Cited by 37 publications

References 28 publications

Polipose nasossinusal: doença inflamatória crônica evolutiva?

Polipose nasossinusal: doença inflamatória crônica evolutiva?

Antifungal Immune Reactivity in Nasal Polyposis

Gene expression analysis reveals novel altered genes in nasal polyps

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