For some individuals with autism, everyday stimuli such as crowded public places, lighting, sounds, and even touch can be highly unpleasant. The increasing prevalence of ASD has driven the research community on the therapy of individuals with autism, especially children/adolescents, to improve and accommodate the condition. This research explores social gaming and gaming design approaches to support meaningful dialogs and enhance interaction. Through careful support and management from many different disciplinary areas, addressing accessibility issues could assist individuals with health issues like obesity, poor self-related health issues (diabetes and heart diseases), ASD, and visual impairments to welfare and emotional needs, too.