The Relationship of Plasma Glucose and Glycosylated Hemoglobin A1C Levels Among Nondiabetic Trauma Patients

Kopelman, Tammy R.; O’Neill, Patrick J.; Kanneganti, Shalini; Davis, Karole M.; Drachman, David A.

doi:10.1097/ta.0b013e318161b0ab

Cited by 31 publications

(34 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the purpose of our investigation was to evaluate hyperglycemia in orthopaedic trauma patients without a history of diabetes. While authors of previous studies have commented that patients with stress-hyperglycemia may include both undiagnosed diabetics and nondiabetics 17,23 , a recent prospective study demonstrated that nearly 5% of general trauma patients were diagnosed with occult diabetes mellitus on the basis of hemoglobin A1C blood values 27 . Such laboratory values were not routinely collected at our institution, and therefore patients with occult diabetes could not be identified from this investigation.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Hyperglycemia and Surgical-Site Infection in Orthopaedic Surgery

Richards

Kauffmann

Zuckerman

et al. 2012

The Journal of Bone & Joint Surgery

178

105

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Relationship of Hyperglycemia and Surgical-Site Infection in Orthopaedic Surgery

Richards

Kauffmann

Zuckerman

et al. 2012

The Journal of Bone & Joint Surgery

178

105

View full text Add to dashboard Cite

“…Overproduction of counterregulatory hormones and cytokines leads to failure of insulin to suppress hepatic gluconeogenesis in a hyperglycemic environment [15]. Many studies have been done to demonstrate the significant portions of hospitalized patients exhibiting hyperglycemia, many of whom meet the criteria for diabetes, with no history of a previous diagnosis of the disease [16, 17]. …”

Section: Discussionmentioning

confidence: 99%

Association of Blood Glucose and Clinical Outcome after Mechanical Thrombectomy for Acute Ischemic Stroke

et al. 2018

View full text Add to dashboard Cite

Background: Elevated blood glucose levels following acute ischemic stroke have been associated with adverse clinical outcomes in thrombolytic and nonthrombolytic treated patients. The current study examined multiple blood glucose parameters and their association with modified Rankin Scale (mRS) score at 3 months following mechanical thrombectomy and hospital discharge. Methods: Acute ischemic stroke patients undergoing mechanical thrombectomy with a retrievable stent at two stroke centers were studied. Admission blood glucose level, maximum blood glucose during the hospital stay, and serial blood glucose measurements within the first 24 h of hospital admission were recorded. Variability in blood glucose level was represented by the standard deviation of the serial measurements within the first 24 h. The following demographic and clinical data was also collected: age, sex, baseline NIHSS score, onset-to-reperfusion times, hemoglobin A1c, and stroke mechanism. Results: 79 patients were identified; at 3 months, 35 patients had an mRS score of 0–2 and 44 had had an mRS of 3–6. Among the blood glucose variables, standard deviation of blood glucose in the first 24 h following admission and maximum blood glucose during hospital stay were significantly higher in the mRS 3–6 group. In multivariate logistic regression analysis, only the standard deviation of blood glucose remained significant (OR = 1.07, 95% CI = 1.02–1.11, p = 0.003) in a model that adjusted for admission NIHSS score (p = 0.016) and number of stent retriever passes (p = 0.042). Conclusions: Greater blood glucose variability following acute ischemic stroke is associated with worse clinical outcome in patients undergoing mechanical thrombectomy.

show abstract

“…2 Levetan et al 4 followed over 1000 consecutive adult patients and found an overall 13% incidence of hyperglycemia and a 33% incidence of hyperglycemia in surgical patients who presented without the diagnosis of diabetes. Kopelman et al 5 found an 18% incidence of hyperglycemia in their population of over 1000 nondiabetic trauma patients.…”

Section: Introductionmentioning

confidence: 98%

Does Stress-Induced Hyperglycemia Increase the Risk of Perioperative Infectious Complications in Orthopaedic Trauma Patients?

Karunakar

Staples²

2010

Journal of Orthopaedic Trauma

View full text Add to dashboard Cite

Mean perioperative glucose levels greater than 220 mg/dL (HGI greater than 3.0) were associated with a seven times higher risk of infection in orthopaedic trauma patients with no known history of diabetes mellitus. Further prospective studies are needed to study the effects of stress-induced hyperglycemia and to determine whether this physiological response is protective or detrimental to the postoperative trauma patient.

show abstract

The Relationship of Plasma Glucose and Glycosylated Hemoglobin A1C Levels Among Nondiabetic Trauma Patients

Cited by 31 publications

References 18 publications

Relationship of Hyperglycemia and Surgical-Site Infection in Orthopaedic Surgery

Relationship of Hyperglycemia and Surgical-Site Infection in Orthopaedic Surgery

Association of Blood Glucose and Clinical Outcome after Mechanical Thrombectomy for Acute Ischemic Stroke

Does Stress-Induced Hyperglycemia Increase the Risk of Perioperative Infectious Complications in Orthopaedic Trauma Patients?

Contact Info

Product

Resources

About