The Relationship of Plasma Homocysteine Levels and the Methylenetetrahydrofolate Reductase C677T Gene Polymorphism to Ankylosing Spondylitis in a Chinese Population

Mao, Ni; Chen, Jinwei; Peng, Wenfeng; Chen, Lixiao; Xie, Xiaoqing

doi:10.5606/tjr.2012.029

Cited by 1 publication

(6 citation statements)

References 14 publications

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“…Of the 9 studies included in this analysis, 4 recruited AS patients on MTX [ 35 – 37 , 41 ], 2 of which used folate supplementation [ 35 , 36 ]. Of the other 5 studies, 3 didn’t use MTX [ 38 – 40 ] and 2 didn’t mention any treatment method [ 16 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies indicated that the TT genotype of the MTHFR C677T polymorphism exhibits higher plasma HCY concentrations than CT heterozygotes and CC homozygotes [ 58 , 59 ]. Besides, Mao et al reported that high plasma HCY levels are associated with MTHFR 677TT polymorphism as compared with the CC or CT genotype in AS patients [ 34 ]. In this meta-analysis, subgroup analysis showed no significant correlation between all 3 genotypes of the MTHFR C677T polymorphism and HCY levels in AS.…”

Section: Discussionmentioning

confidence: 99%

“…Out of a total of 15 relevant studies found, 9 original studies met our inclusion criteria and were selected for this meta-analysis. These 9 studies were published between 2005 and 2020 and included 778 AS patients and 522 controls [16,[34][35][36][37][38][39][40][41]. Of the 9 studies, 4 were conducted in Asia, 3 in Asia-Europe (Turkey), 1 in Europe, and 1 in South America.…”

Section: Publication Search and Study Characteristicsmentioning

confidence: 99%

“…Of the 9 studies, 4 were conducted in Asia, 3 in Asia-Europe (Turkey), 1 in Europe, and 1 in South America. As of the controls, 1 study included non-inflammatory low back pain [39], 1 included osteoarthritis or soft tissue rheumatism [41], and the other 7 included healthy controls [16,[34][35][36][37][38]40]. Our methodological quality assessment showed the NOS scores of included studies ranged from 7 to 8.…”

Section: Publication Search and Study Characteristicsmentioning

confidence: 99%

“…However, the conclusions of HCY levels reported in AS patients are inconsistent. Several studies reported high levels of serum/plasma HCY levels in AS patients [34][35][36][37][38]. In contrast, others claimed that HCY levels in AS patients were similar or lower compared with control patients [16,[39][40][41].…”

Section: Introductionmentioning

confidence: 99%

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Association of homocysteine with ankylosing spondylitis: a systematic review and meta-analysis

Sai

et al. 2021

Adv Rheumatol

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Background Hyperhomocysteinemia is associated with autoimmune diseases such as ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA). Current findings regarding plasma/serum homocysteine (HCY) levels in AS patients are inconsistent. This study aims to systematically evaluate the association between circulating HCY levels and AS. Methods Online electronic databases (PubMed, Web of Science, Embase, ScienceDirect, China National Knowledge Infrastructure (CNKI), and Wanfang data) were used to retrieve all relevant articles published up to May 7, 2020. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using the random-effect model, Stata16 software. Results Nine articles containing 778 AS patients and 522 controls were included in this meta-analysis. No significant differences in HCY levels were found between AS and control groups (pooled SMD = 0.46, 95% CI = − 0.30 to 1.23, P = 0.23). However, subgroup analysis suggested that HCY levels were significantly higher (P < 0.05) in the AS group treated with methotrexate (MTX) compared with the control group. In contrast, HCY levels were significantly (P < 0.05) lower in the AS group receiving anti-TNF-α treatment compared with the control group. No significant differences were detected between HCY levels and disease activity scores (Bath AS disease activity index, BASDAI), and methylenetetrahydrofolate reductase (MTHFR) C677T genotype. Conclusion This meta-analysis indicates that HCY levels are similar between AS and controls, and do not correlate with disease activity. However, different medical treatments cause fluctuations of circulating HCY levels in AS patients. Further and larger-scale studies are needed to confirm these findings. Trial registration This study was registered at international prospective register of systematic reviews (PROSPERO), registration number: CRD42020184426.

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