The Relationship of Pregnancy-Associated Plasma Protein A and Human Chorionic Gonadotropin with Adverse Pregnancy Outcomes: A Prospective Study

Pakniat, Hamideh; Bahman, Atieh; Ansari, Iman

doi:10.1007/s13224-019-01217-3

Cited by 12 publications

(9 citation statements)

References 37 publications

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“…According to our study, while there was a significant difference in PAPP-A and NT measurements between SGA, AGA, and LGA groups, no significant difference was observed between β-hCG levels. Pakniat et al, in their study with 994 pregnant women, found that (in line with our study) low PAPP-A levels were associated with SGA, but β-hCG levels did not show this relationship (33). In the study by Hansen et al from Denmark, 1155 pregnant women were divided into two groups as SGA and AGA.…”

Section: Discussionsupporting

confidence: 88%

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Soysal

Bıyık

Erten

et al. 2021

Gynecol Obstet Reprod Med

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OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma and the predicted weight at birth: Small for gestational age and large for gestational age. STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent first-trimester aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational age, and those over the 90th percentile were defined as large for gestational age. RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for gestational age However, due to its low correlation, it is not a suitable screening test for clinical practice.

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Section: Discussionsupporting

confidence: 88%

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Soysal

Bıyık

Erten

et al. 2021

Gynecol Obstet Reprod Med

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“…We have found studies showing similar results, in which they also observed a greater risk of preeclampsia, preterm labor and low birth weight, in pregnant women with low levels of PAPP-A [8][9][10].…”

Section: Preeclampsiasupporting

confidence: 71%

Retrospective Study of the Metrorrhagia of the First Trimester. Follow-up and Gestational Complications

Cándenas¹,

González-Mesa²,

Frías³

et al. 2023

Preprint

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Background and Objectives: The purpose of this study was to describe and evaluate the bleeding that occurs during the first weeks of gestation and its implications throughout pregnancy. Secondarily, we assessed the associated complications in order to identify potential risk factors that could be used to select women at higher risk of adverse outcomes that could benefit from an early diagnosis and improved monitoring. Materials and Methods: We made a selection of all the women who consulted in the Emergency Department of the Hospital QuirónSalud in Malaga on 2015 presenting with first trimester metrorrhagia. We refer to first trimester metrorrhagia as that which occurs until week 12+6. Once these pregnant women were identified, we studied several variables not related to the gestation and some others associated with it and its natural course. Results: The average age of the patients assessed was 34.1. Associated gestational complications were metrorrhagia in the second trimester (6.3%), threatened preterm labour (7.4%), preeclampsia (2.5%), gestational diabetes (7.4%), late abortion (1.2%) and early postpartum hemorrhage (1.8%). We sought associations to assess possible risk factors, establishing an increased maternal age as an aggravating factor for the development of complications. We also studied gestational complications finding a higher prevalence of them in older women, such as prematurity (33.11 vs 34.48 years), gestational diabetes (33.11 vs 36.06 years) and preeclampsia (33.25 vs 35 years). Conclusions: Maternal age is a risk factor for first-trimester spontaneous miscarriage and for the development of complications of pregnancy. It is crucial to perform a correct screening of different pathologies throughout the pregnancy to anticipate potential complications.

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“…Preeclampsia is detected when the blood pressure exceeds 140/90 mmHg after the 20 th week of pregnancy, along with proteinuria≥300 mg in the 24 hour urine sample or ≥n +1 in the urine dipstick [11].…”

Section: Patientsmentioning

confidence: 99%

“…There are several clinical, biophysical, and biochemical tests to identify women at risk of preeclampsia, but the results of studies reveal that their predictive value is low in the early diagnosis of preeclampsia [10]. One study also showed that low pregnancy-associated plasma protein-A might be used to predict preeclampsia [11].…”

Section: Introductionmentioning

confidence: 99%

Preeclampsia and Its Associated Risk Factors: A Case-control Study in Qazvin Province

Mirabedini

Pakniat²,

Mahdavi³

et al. 2022

J Inflamm Dis

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Background: Preeclampsia is one of the common disorders in pregnancy. It is characterized by hypertension and proteinuria in the second half of pregnancy. It is also one of the three main causes of death in pregnant women. Objective: This study investigated the risk factors of preeclampsia in women referred to Kowsar Hospital in Qazvin Province, Iran. Methods: In this case-control study, after reviewing 7855 cases of pregnant women referred to Kowsar Hospital in 2016, 171 hospitalized patients with severe preeclampsia were put in the case group, and 171 patients with delivery problems were in the control group. Then, we compared the collected data about risk factors, such as a history of preeclampsia, hypertension, smoking, diabetes mellitus, infertility, twin, and body mass index, in both groups. Results: The Mean±SD age of the pregnant women with preeclampsia was 31.19±6.42 years with an interquartile interval of 26-35 years. History of preeclampsia (P=0.02), hypertension (P=0.001), and body mass index (P=0.001) were significantly higher in the preeclampsia group than in the control group. Also, there was no significant relationship between a history of diabetes mellitus, infertility, or twin with preeclampsia (P<0.05). Conclusion: This study showed that the risk factors of a history of preeclampsia, hypertension, and body mass index significantly differed between the case and control groups.

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The Relationship of Pregnancy-Associated Plasma Protein A and Human Chorionic Gonadotropin with Adverse Pregnancy Outcomes: A Prospective Study

Cited by 12 publications

References 37 publications

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight

Retrospective Study of the Metrorrhagia of the First Trimester. Follow-up and Gestational Complications

Preeclampsia and Its Associated Risk Factors: A Case-control Study in Qazvin Province

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