The relationship of recurrent aphthous stomatitis and Helicobacter pylori, cytokine gene polymorphism and cobalamin

Abstract

Background/Aims: The aim of the present study was to investigate whether Helicobacter pylori causes or triggers recurrent aphthous stomatitis (RAS) through cytokine gene polymorphism and/or cobalamin deficiency. Materials and Methods: Thirty-six patients with RAS and 130 patients without RAS were genotyped for IL-1β (−511C/T) and IL-6 (−174G/C) and evaluated for H. pylori infection and serum cobalamin level. Results: The patient groups according to RAS had similar rates of H. pylori gastritis and interleukin genotypes/alleles, and there was a non-significant difference between serum cobalamin levels (p>0.05). RAS patients with H. pylori gastritis showed a higher frequency (51.9%) of GC IL-6 genotype than RAS patients without H. pylori gastritis (11.1%) (p=0.036). Non-GG genotype and C allele were increased in patients without RAS and with H. pylori gastritis (p<0.05). Patients with H. pylori gastritis showed a lower value of serum cobalamin without statistical significance, although this difference was more prominent in RAS patients (p=0.07). Conclusion: The carriage of the C allele of IL-6 may lead a susceptibility to chronic gastric inflammation after contamination with H. pylori. If H. pylori infection is justified as a predisposing factor for RAS and its severity by further studies, we can speculate that subjects with genetic susceptibility to this infection may benefit from H. pylori eradication treatment with respect to RAS.

Association study of interleukin‐1 family, interleukin‐6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

“…found significantly higher frequency of IL‐6 ‐174 CC genotype in a group of patients with RAS. In contrast, other authors could not confirm any association between IL‐6 promoter variants and RAS in different populations . It is in agreement with our findings where similar frequencies of the IL‐6 genotypes and/or alleles between patients with RAS and healthy controls were found.…”

“…15,16 Several studies evaluated the potential association between IL-1A, IL-1B, IL-1RN, or IL-6 gene polymorphisms and an increased susceptibility to aphthous stomatitis with conflicting results. 8,[17][18][19][20][21][22][23] To date, no study has been conducted on the IL-6R gene variants in this disease.…”

A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis

“…[1][2][3] In general, these patients have eating and speaking problems. 2 Pathogenesis of RAS is related to genetic, immunological, microbial factors as well as local or systemic conditions.…”

“…2 Pathogenesis of RAS is related to genetic, immunological, microbial factors as well as local or systemic conditions. 1,3,4 Since the characteristics of peptic ulcers and oral aphthous ulcers have histological similarities, it was believed that development of RAS could be due to H. pylori. [1][2][3][4] The person infected with H. pylori can be an asymptomatic carrier.…”

“…1,3,4 Since the characteristics of peptic ulcers and oral aphthous ulcers have histological similarities, it was believed that development of RAS could be due to H. pylori. [1][2][3][4] The person infected with H. pylori can be an asymptomatic carrier. 1 Helicobacter pylori is a Gram-negative, microaerophilic, spiral-shaped bacteria found in the mucosa of the gastric region.…”