The relationship of serum aminotransferase levels to viral load and genotype in chronic hepatitis C

Delic, Dragan; Nesic, Zorica; Prostran, Milica; Maksić, Nebojša; Cutovic, Milisav; Simonović, Jasmina; Svirtlih, Neda

doi:10.2298/jmb0504247d

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…Zechini et al found a relation between HCV viral load and AST. However, we observed a negative correlation between viral load and AST in genotype 3b that may be due to poor immune response resulting in lower AST level and higher viral load and vise versa lead to liver damage [ 19 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a

Ahmad

Ijaz

Javed

et al. 2011

Virol J

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BackgroundSeveral factors have been proposed to assess the clinical outcome of HCV infection. The correlation of HCV genotypes to possible serum markers in clinical prediction is still controversial. The main objective of this study was to determine the existence of any correlation between HCV genotypes to viral load and different clinical serum markers.MethodsWe performed a prospective cross-sectional and observational study. About 3160 serum HCV RNA positive patients were chosen from 4020 randomly selected anti-HCV positive patients. Statistical analysis was performed using the SPSS 16 software package. ROC (receiver operating characteristics) curves were used to compare diagnostic values of serum markers to predict genotypes.ResultsThe most prevalent genotype was 3a (73.9%) followed by 1a (10.7%), 4a (6.4%) and 3b (6.1%) in Pakistani population. No correlation was found between viral load and serum markers for genotype 3a in a large no. of sample (n = 2336). While significant correlation was observed between viral load and AST in genotype 3b, ALP with viral load and ALT for genotype 1a. Patients with genotype 4a showed a significant inverse correlation with viral load and Hb level and AST with ALP. For genotype 4a, AUC (area under the curve) of ALT, ALP, AST, bilirubin, Hb level and viral load was 0.790, 0.763, 0.454, 0.664, 0.458 and 0.872 respectively.ConclusionsIn conclusion, there was a significant variable response of HCV genotypes with serum markers. Severity of disease is independent of serum marker level in genotype 3a, while the liver damage in genotype 4a may associate with viral cytopathic effect as well as the immune-mediated process. An index using six serum markers may correctly predict genotype 4a in patients with ≥75% accuracy.

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Section: Discussionmentioning

confidence: 99%

HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a

Ahmad

Ijaz

Javed

et al. 2011

Virol J

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“…Clinical consequences of HCV infection depend on the balance between replication rate of the virus and specific, rapid and effective response of immune system to the virus (21,28). A number of clinical, biochemical and histological parameters are used in the evaluation of CHC progression (29).…”

Section: Discussionmentioning

confidence: 99%

“…The grade of elevated ALT is accepted as a marker of liver injury and it is used as a criterion in starting antiviral therapy or monitoring response to therapy (14,21,28). It has also been determined that HCV RNA titers are correlated with response to antiviral therapy (18,43).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Nar¹,

Sezgin²

2016

vhd

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ÖZObjective: Liver biopsy, as well as some non-invasive biochemical parameters are also used in monitoring patients with chronic hepatitis C (CHC). The aim of this study was to investigate the relationship between serum biochemical markers and HCV RNA titers in patients with previously untreated CHC. Materials and Methods:We performed a retrospective study on anti-HCV and HCV-RNA-positive 82 patients with CHC. Eighty two healthy subjects constituted the control group. Complete blood counts, total protein (TP), albumin (ALB), C-reactive protein (CRP), γ-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and HCV RNA levels were recorded for each patient and control subject. Neutrophil-lymphocytes ratio (NLR) and the fibrosis index based on the 4 factors (FIB-4 index) were calculated using formulas.Results: There was a significant difference in ALT, AST, GGT, TP , CRP , red cell distribution width (RDW), lymphocytes (LYM), platelets (PLT), FIB-4, and NLR between CHC patients and controls (p=<0.05

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“…Another concern about hepatitis C is the association between HCV genotypes and serum biochemical markers (platelet count, bilirubin, hyaluronic acid, collagen, and elevated alanine aminotransferase/aspartate aminotransferase [ALT/AST]), and conflicting results have observed in this regard. [ 11 12 13 ] Elevated liver enzymes reflect the inflammation/damage to cells in the liver, and for HCV infection, it is mainly related to the patient's immune response to the viral infection in the liver and can fluctuate. [ 14 ] Further, many factors such as serum HCV RNA load,[ 12 ] HIV infection, co-infection with another hepatitis virus, or having another liver disease can change the liver enzyme balance.…”

Section: Introductionmentioning

confidence: 99%

“…[ 11 12 13 ] Elevated liver enzymes reflect the inflammation/damage to cells in the liver, and for HCV infection, it is mainly related to the patient's immune response to the viral infection in the liver and can fluctuate. [ 14 ] Further, many factors such as serum HCV RNA load,[ 12 ] HIV infection, co-infection with another hepatitis virus, or having another liver disease can change the liver enzyme balance. [ 15 ] Hence, this present study, as the third aim and for the first time in Iran, investigated the association between the level of liver enzymes with HCV genotypes to find whether enzymes level not only can be considered as markers for each genotype and disease severity but can also be used as an indicator for treatment management.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus in Iran; transmission routes, growth in 3a genotype distribution, and lack of liver marker relation with genotypes

2020

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Background: The hepatitis C virus (HCV) outbreak in Iran is increasing. This study investigated the dissemination and transmission routes of HCV genotypes in different regions of Iran. The relationship between serum biochemical markers and viral genotypes was also assessed to find whether liver enzymes level can be considered as the markers for HCV genotypes. Materials and Methods: HCV-infected patients from different provinces of Iran (from August 2017 to March 2019) were enrolled. Nested reverse transcriptase polymerase chain reaction (PCR)-restriction fragment length polymorphism and real-time PCR were used to discover the genotypes. The infection transmission routes in the study population were investigated and recorded. Serum samples with equal viral loud from the patients without other liver disorders were recruited to explore the association between the genotypes and the liver biochemical markers. Results: One thousand serum samples positive for the HCV genome were recruited. Genotype 3a was the most prevalent in the north, while genotype 1a was dominant at the center. In total, genotype 3a was the dominant genotype closely followed by 1a. Needle sharing by addicts was the most common transmission way of infection in Iran. This way was also the most for genotype 3a dissemination, and genotype 1a was transmitted mostly between family members. No significant association ( P > 0.05) was observed between biochemical marker titers and HCV genotypes. Conclusion: A shift in the distribution profile of HCV genotypes, related to the transmission routes, has happened over time. Public awareness of the main routes of HCV transmission can break the cycle of transmission. Liver enzyme values in HCV-infected patients showed no relation with genotypes and only represented hepatocellular dysfunction.

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The relationship of serum aminotransferase levels to viral load and genotype in chronic hepatitis C

Cited by 5 publications

References 20 publications

HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a

HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Hepatitis C virus in Iran; transmission routes, growth in 3a genotype distribution, and lack of liver marker relation with genotypes

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