The Relationship of Serum S100B Levels with Infarction Size and Clinical Outcome in Acute Ischemic Stroke Patients

Selçuk, Özlem; Yayla, Vildan; Çabalar, Murat; Güzel, Vildan; Uysal, Samiye; Gedikbaşı, Asuman

doi:10.5152/npa.2014.7213

Cited by 23 publications

(15 citation statements)

References 27 publications

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“…Furthermore, serum levels of the astrocyte calcium-binding protein, S100B, also did not differ statistically between the AIS + D and AIS groups, although a trend towards higher levels in the AIS + D group was seen at p = 0.065. Serum S100B is also elevated after acute ischemic stroke, showing a positive correlation to infarct size [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated plasma biomarkers of inflammation in acute ischemic stroke patients with underlying dementia

Choi

Kim

et al. 2020

BMC Neurol

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Background The blood-brain barrier has been a hindrance to developing blood-based diagnostic tests for dementias, as it limits the appearance of brain biomarkers in the blood. Our aim was to see if the natural opening of the blood-brain barrier induced by ischemic stroke would increase serum levels of inflammatory biomarkers known to be elevated in the brains of patients with Alzheimer’s disease and other neurodegenerative dementias. Methods Forty-three patients with acute ischemic stroke presenting to Stony Brook University Hospital were prospectively enrolled in the study. Eight of these patients were clinically diagnosed as having an underlying neurodegenerative dementia. Blood was drawn acutely within 72 h of stroke symptom onset, and serum levels of the classic inflammatory biomarkers, interleukin-6 (IL-6) and C-reactive protein (CRP) were measured, along with levels of S100B protein (S100B) and complement C3 (CC3). Results Serum levels of IL-6 and CRP in patients with acute ischemic stroke and underlying dementia (AIS + D) were significantly higher ( p = 0.002 and 0.003, respectively) than in patients with acute ischemic stroke alone (AIS). Serum levels of S100B and CC3 did not differ significantly between the groups. Conclusions This study supports the possibility that opening of the blood-brain barrier may enhance the blood appearance of brain tissue markers of inflammation associated with neurodegenerative dementia. Further study is warranted to test this possibility, given the recent emergence of methods to open the blood-brain barrier for diagnostic or therapeutic purposes.

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Section: Discussionmentioning

confidence: 99%

Elevated plasma biomarkers of inflammation in acute ischemic stroke patients with underlying dementia

Choi

Kim

et al. 2020

BMC Neurol

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“…To date, however, the exact aetiology and pathogenetic mechanisms of IS remain unclear. Recently, increasing evidence has indicated that serum S100B levels may be used as a novel biomarker for IS 33 – 35 . Nevertheless, the mechanisms leading to elevated serum S100B are unknown, but this is believed to lead to aggravation of the development of IS.…”

Section: Discussionmentioning

confidence: 99%

“… 47 reported that serum-S100B was positively correlated with plasma high-sensitivity C-reactive protein. In addition, clinical and experimental studies have demonstrated that the levels of serum S100B were elevated in patients with IS 33 , 34 , 48 . Furthermore, a previous study found that knockdown of S100B in atherosclerotic mice can improve the brain’s recovery function and reduced infarctions 49 .…”

Section: Discussionmentioning

confidence: 99%

Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population

Wang

Huang

et al. 2018

Sci Rep

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The levels of serum S100B were elevated in patients with ischemic stroke (IS), which may be a novel biomarker for diagnosing IS. The aim of this study was to investigate the association of S100B polymorphisms and serum S100B with IS risk. We genotyped the S100B polymorphisms rs9722, rs9984765, rs2839356, rs1051169 and rs2186358 in 396 IS patients and 398 controls using polymerase chain reaction-single base extension (SBE-PCR). Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA). Rs9722 was associated with an increased risk of IS (AA vs. GG: adjusted OR = 2.172, 95% CI, 1.175–4.014, P = 0.013; dominant: adjusted OR = 1.507, 95% CI, 1.071–2.123, P = 0.019; recessive: adjusted OR = 1.846, 95% CI, 1.025–3.323, P = 0.041; additive: adjusted OR=1.371, 95% CI, 1.109-1.694, P = 0.003). The A-C-C-C-A haplotype was associated with an increased risk of IS (OR = 1.325, 95% CI, 1.035–1.696, P = 0.025). In addition, individuals carrying the rs9722 GA/AA genotypes had a higher serum S100B compared with the rs9722 GG genotype in IS patients (P = 0.018). Our results suggest that the S100B gene rs9722 polymorphism may contribute to the susceptibility of IS, probably by promoting the expression of serum S100B.

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“…S100β is among the family of non-ubiquitous Ca 2+ -modulated proteins and it is mainly produced by astrocytes. It plays an important role in nerve growth, differentiation, and reparation of nerves [42,43,44]. It is a glial protein, with a molecular weight of approximately 10 kDa, located intracellularly [45] and found in abundance in the cerebral astroglial compartment, peripheral Schwann cells, and extraneuronally in melanocytes, adipocytes, and chondrocytes [46].…”

Section: Introductionmentioning

confidence: 99%

Point-of-Care Surface Plasmon Resonance Biosensor for Stroke Biomarkers NT-proBNP and S100β Using a Functionalized Gold Chip with Specific Antibody

Harpaz

Koh

Marks

et al. 2019

Sensors

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Surface-plasmon-resonance (SPR) is a quantum-electromagnetic phenomenon arising from the interaction of light with free electrons at a metal-dielectric interface. At a specific angle/wavelength of light, the photon’s energy is transferred to excite the oscillation of the free electrons on the surface. A change in the refractive-index (RI) may occur, which is influenced by the analyte concentration in the medium in close contact with the metal surface. SPR has been widely used for the detection of gaseous, liquid, or solid samples. In this study, a functionalized specific SPR chip was designed and used in a novel point-of-care SPR module (PhotonicSys SPR H5) for the detection of the stroke biomarkers NT-proBNP and S100β. These biomarkers have proven to be good for stroke diagnosis, with sensitivity and specificity of >85%. Specific detection was done by binding a biomolecular-recognizing antibody onto the Au SPR-chip. Detection was tested in water and plasma samples. NT-proBNP and S100β were detected in a range of concentrations for stroke, from 0.1 ng/mL to 10 ng/mL. The RI of the blank plasma samples was 1.362412, and the lowest concentration tested for both biomarkers showed a prominent shift in the RI signal (0.25 ng/mL NT-proBNP (1.364215) and S100β (1.364024)). The sensor demonstrated a clinically relevant limit-of-detection of less than ng/mL.

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The Relationship of Serum S100B Levels with Infarction Size and Clinical Outcome in Acute Ischemic Stroke Patients

Abstract: The detection of high S100B levels in peripheral circulation after acute ischemic stroke and the correlations of S100B levels with infarct size (good) and disability (poor) imply that S100B protein may be used as a peripheral marker in acute ischemic stroke patients.

Cited by 23 publications

References 27 publications

Elevated plasma biomarkers of inflammation in acute ischemic stroke patients with underlying dementia

Elevated plasma biomarkers of inflammation in acute ischemic stroke patients with underlying dementia

Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population

Point-of-Care Surface Plasmon Resonance Biosensor for Stroke Biomarkers NT-proBNP and S100β Using a Functionalized Gold Chip with Specific Antibody

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