The relationship of soluble klotho level with uremic cardiomyopathy and ecocardiographic parameters in hemodialysis patients

Abstract

There are studies reporting that soluble kltho (sKlotho) deficiency plays a role in cardiovascular disease in addition to traditional risk factors such as diabetes, hypertension, anemia, smoking, and excessive volume burden. Our aim in this study was to investigate the relationship of sKlotho with uremic cardiomyopathy and echocardiographic parameters in patients receiving hemodialysis treatment. According to the median value, the sKlotho value was divided into two groups as ≥1.24 and <1.24 ng/ml. Ventricular wall thicknesses, ejection fractions, left atrium, M mode aorta systole, and diastole diameter measurements were taken. The left ventricular mass (LVM) was calculated using the Devereux formula. There were significant differences between the two groups in terms of age, number of patients with diabetes mellitus, comorbidity, dialysis time, sKlotho, phosphorus, parathormone, and albumin parameters. No significant difference was found between the two groups that were separated according to the median sKlotho value, when the echocardiographic parameters of interventricular septum thickness, left ventricular posterior wall thickness, left atrial diameter, left ventricular ejection fraction, and LVM index were compared. In conclusion, sKlotho is not a marker for showing and predicting uremic cardiomyopathy in hemodialysis patients.

The controversy of klotho as a potential biomarker in chronic kidney disease

“…Similarly, Nowak et al (2014) found no association between higher sKlotho levels and a lower risk for mortality in 329 MHD patients with sKlotho either as a continuous variable or a categorical variable in multivariable-adjusted analysis after 2.53 years of follow-up ( Nowak et al, 2014 ). Similar inconsistent results were also demonstrated by other recent prospective cohort studies ( Zheng et al, 2018 ; Adamska-Tomaszewska et al, 2020 ; Erkus et al, 2021 ). The inconsistent studies were summarized and the average score was 7 stars, as shown in Table 3 .…”

Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease–Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows

“…Furthermore, the decline of serum sKlotho in CKD has also been associated with carotid intima-media thickening [69], atherosclerosis [70,71], arterial stiffness [72] and hypertension [73]. However, this remains a controversial topic, as certain studies have not identified such associations in CKD [64,[74][75][76][77]. Unfortunately, studies with urinary sKlotho are scarce, so the possible value of urinary sKlotho as a marker or predictor of cardiovascular abnormalities among the CKD-MBD setting has limitations.…”