The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

Yıldırım, Tülay; Yıldırım, Oğuzhan

doi:10.5455/medscience.2014.03.8211

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…At the same time, our examined patients were found to have GM damages, such as antral gastritis, pangastritis, erosions, and hemorrhages, which were unassociated with H. pylori . Endoscopic and PCR data suggest that H. pylori plays no significant role in GM damage in SLE and APS, which agrees with the data available in the literature [14, 49, 73]. It can be said that in patients with SLE and APS, the GM is colonized by H. pylori [74].…”

Section: Discussionsupporting

confidence: 85%

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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Background. The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems. Objective. To define the role of H. pylori and drugs in the development of GM damages in SLE and APS. Methods. A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of H. pylori in the gastric biopsy specimens was determined using polymerase chain reaction. Results. Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of H. pylori. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage. Conclusion. There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.

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Section: Discussionsupporting

confidence: 85%

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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“…The association between infection and autoimmune diseases over the last twenty years has been increasingly supposed [16,27]. Several infectious agents such as Cytomegalovirus, Parvovirus B19, Epstein Barr virus and Retrovirus, might play a major role in the pathogenesis of SLE [18,34]. However, there is a different relationship between SLE and Helicobacter, from that of other infections.…”

Section: Discussionmentioning

confidence: 99%

“…Amongst the various infectious agents proposed as autoimmunity triggering agents, Helicobacter pylori (H.pylori) is one of the most widely studied [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Association of Helicobacter pylori Infection with Systemic Lupus Erythematosus

Ejtehadi¹,

Roghanian²,

Bonakdar³

2017

J Clin Cell Immunol

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Objective: Systemic Lupus Erythematosus (SLE) is an autoimmune disease of unknown etiology. However, a complex combination of host and environmental factors are believed to play a pivotal role. In the pathogenesis of SLE, several infectious agents have been held responsible such as Cytomegalovirus, Parvovirus B19, Epstein Barr virus and Retrovirus. There is a variable relationship between SLE and Helicobacter, which is different from that of lupus and other infections. The aim of this study was to investigate the association between Helicobacter pylori (H.pylori) infection and SLE development. Method:In this study, 82 serum samples and 65 stool samples were collected from the SLE patients as well as the control group, respectively. An enzyme-linked immunosorbent assay (ELISA) was used to detect the presence of specific IgG/IgM antibodies against H.pylori in all serum samples. The presence of H.pylori antigen was examined in all stool samples by using stool antigen test. Suitable statistical analysis was applied.Results: Thirteen (15.9%) out of 82 SLE patients and 30 (36.6%) out of 82 control group were anti-H.pylori IgM seropositive. There was a significant difference between the level of IgM in SLE patients and control group (p<0.05). Anti-H.pylori IgG antibodies were present in 37 (45.1%) of SLE patients and in 41 (50%) of the control group without any significant difference. Regarding stool antigen examination, there were 24 (36.9%) and 26 (42/6%) positive samples among the SLE patients and control group, respectively. There was no significant difference between the patients and controls samples in the number of stool antigen test positive samples (p>0.05). Conclusions:Based on data obtained in this study, it is concluded that there was a significant difference between the number of IgM seropositive in SLE patients and control group, which shows that SLE disease may have an inhibitory role in H.pylori infection occurance.

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The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

Cited by 2 publications

References 9 publications

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Association of Helicobacter pylori Infection with Systemic Lupus Erythematosus

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