The Relationship of the Blood Sugar Level to the Severity of Anaphylactic Shock

Hl, Dhar; Sanyal, R. K.; West, G. B.

doi:10.1111/j.1476-5381.1967.tb02005.x

Cited by 17 publications

(17 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the pertussis-sensitized animals, hypoglycaemia appeared to be caused by an increase in peripheral uptake of glucose [3,5,23] and by a decrease in hepatic phosphorylase activity [24]. Dhar et al [9] reported that in insulin-resistant diabetic patients the pertussis vaccine succeeded in reducing blood glucose concentration for several weeks.…”

Section: Discussionmentioning

confidence: 99%

Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: Effect on spontaneous diabetic rats

et al. 1978

View full text Add to dashboard Cite

Summary. The early phase of insulin secretion to an oral glucose load was blunted in spontaneous diabetic rats, The blunted insulin secretion was associated with markedly impaired glucose tolerance. A single injection of the islet activating protein (IAP), a protein derived from the culture medium of Bordetella pertussis, into the spontaneous diabetic rats normalised glucose tolerance. The increase in insulin response to glucose was an important contributing factor to the improvement of glucose tolerance. This curative effect of the IAP on the diabetic state was of long duration; glucose tolerance remained virtually normal over a period of one month in the diabetic rats. Perfusion of the isolated pancreas of the diabetic rats pretreated with IAP showed an increase in insulin response to glucose and loss of suppression of glucagon secretion by noradrenaline.

show abstract

Section: Discussionmentioning

confidence: 99%

Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: Effect on spontaneous diabetic rats

et al. 1978

View full text Add to dashboard Cite

show abstract

“…Mortality of sensitised rats and mice challenged by the specific antigen is diminished in the diabetic state [6][7][8]19]. Arthus and local Shwartzman reactions are also suppressed in diabetes [17,18].…”

Section: Introductionmentioning

confidence: 99%

Effect of Insulin and Alloxan Diabetes on Carrageenin Inflammation in Rats

Ottlecz¹,

Koltai²,

Dekov³

1976

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Some hypersensitivity reactions and allergic responses are known to be increased by insulin treatment and decreased in diabetes. In contrast, the present experiments showed that paw swelling induced by carrageenin in rats was inhibited by insulin. The anti-inflammatory activity, to some extent, paralleled the dose applied and did not appear to be due to hypoglycaemia. Alloxan diabetes in turn increased the vascular response to carrageenin and abolished the anti-inflammatory effect of insulin. The experiments call attention to the possible significance of insulin in the regulation of the acute non-immune inflammatory process.

show abstract

“…The resistance of alloxan-diabetic animals to allergen provocation was also extended to the condition of systemic anaphylaxis [55,56] , when a substantial reduction in the mortality rate, intestinal hemorrhage and plasmatic levels of histamine were evidenced [57] . In addition, diabetes was shown to affect the sensitization stage of the anaphylactic reaction, since the augmentation in total and ovalbumin-specific serum levels of IgE was impaired in diabetic sensitized rats [57] .…”

Section: Diabetes Versus Allergymentioning

confidence: 99%

Down-Regulation of Allergic Responses in Conditions of Experimental Diabetes: A Role for Glucocorticoids?

Silva¹,

Carvalho²,

Cordeiro³

et al. 2008

Neuroimmunomodulation

View full text Add to dashboard Cite

The prevalence of atopic diseases and diabetes is increasing worldwide, though the co-occurrence of both diseases in the same individual is less frequent than predicted. Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to local and systemic allergen challenges in diabetic conditions. Moreover, dysregulation of the hypothalamic-pituitary-adrenocortical axis and elevated endogenous glucocorticoid levels play a pertinent role in some of the pathological-related processes associated with poorly controlled or uncontrolled diabetes.

show abstract

The Relationship of the Blood Sugar Level to the Severity of Anaphylactic Shock

Cited by 17 publications

References 14 publications

Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: Effect on spontaneous diabetic rats

Islet activating protein (IAP) derived from the culture supernatant fluid of Bordetella pertussis: Effect on spontaneous diabetic rats

Effect of Insulin and Alloxan Diabetes on Carrageenin Inflammation in Rats

Down-Regulation of Allergic Responses in Conditions of Experimental Diabetes: A Role for Glucocorticoids?

Contact Info

Product

Resources

About