The relationships between antihypertensive medications and the overall survival of patients with pancreatic cancer: a systematic review and meta-analysis

Jiang, Wenkai; He, Ru; Lu, Yongyan; Zhou, Wence

doi:10.1080/17474124.2022.2088506

Cited by 6 publications

(4 citation statements)

References 39 publications

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“…As another factor of the metabolic syndrome, hypertension leads to cardiovascular events and an increase in pts' morbidity and mortality. In a meta-analysis of 12 study cohorts, the use of antihypertensive medication did not correlate to the survival in pancreatic cancer [15]. In our study cohort, hypertension did not present a prognostic factor for survival, indicating the antihypertensive therapy of pancreatic cancer pts to be secondary.…”

Section: Discussioncontrasting

confidence: 60%

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Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients—A Single Center Analysis of 2323 Patients within the Last Decade

Neumann

Schneider

Hilfenhaus

et al. 2023

JCM

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In addition to being risk factors for pancreatic cancer, parameters such as smoking, diabetes, or obesity might also act as potential prognostic factors for the survival of patients initially diagnosed with pancreatic cancer. By implementing one of the largest retrospective study cohorts of 2323 pancreatic adenocarcinoma (PDAC) patients treated at a single high-volume center, potential prognostic factors for survival were evaluated on the basis of 863 cases. Since parameters such as smoking, obesity, diabetes, and hypertension can cause severe chronic kidney dysfunction, the glomerular filtration rate was also considered. In the univariate analyses, albumin (p < 0.001), active smoking (p = 0.024), BMI (p = 0.018), and GFR (p = 0.002) were identified as metabolic prognostic markers for overall survival. In multivariate analyses, albumin (p < 0.001) and chronic kidney disease stage 2 (GFR < 90 mL/min/1.37 m2; p = 0.042) were identified as independent metabolic prognostic markers for survival. Smoking presented a nearly statistically significant independent prognostic factor for survival with a p-value of 0.052. In summary, low BMI, status of active smoking, and reduced kidney function at the time of diagnosis were associated with lower overall survival. No prognostic association could be observed for presence of diabetes or hypertension.

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Section: Discussioncontrasting

confidence: 60%

“…Whether or not Diabetes mellitus itself represents a prognostic factor has not yet been fully elucidated [13,14]. Hypertension as another parameter of the metabolic syndrome is reported to not correlate to survival of pancreatic cancer pts [15].…”

Section: Introductionmentioning

confidence: 99%

Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients—A Single Center Analysis of 2323 Patients within the Last Decade

Neumann

Schneider

Hilfenhaus

et al. 2023

JCM

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“…Various studies analyzing the effect of anti-hypertensive treatment on PC patient survival demonstrate contradictory results. A meta-analysis by Jiang et al (2022) [27] confirmed that the use of anti-hypertensive medication (ACEIs/ARBs, CCBs, diuretics, β-blockers) does not have a negative effect on overall survival of PC patients; thus, they should continue to use these drugs to prevent cardiovascular events. Yang et al (2021) [28] suggested that β-blockers usage before PC diagnosis is not correlated with survival advantage; nevertheless, continuous use before and after diagnosis presented survival benefits.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and impact of overweight and hypertension among patients with pancreatic cancer

Fudalej,

Cichowska,

Badowska-Kozakiewicz

et al. 2024

Oncol Clin Pract

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Introduction. Pancreatic cancer (PC) remains one of the most deadly malignancies with rising incidence. As therapeutical options seem unsatisfactory, great effort should be put into identifying and reducing risk factors as well as distinguishing possible factors influencing patient outcomes. The study aimed to describe the prevalence of overweight and hypertension among PC patients, analyse the possible association between overweight, hypertension and clinicopathological factors and distinguish variables influencing survival. Material and methods. A retrospective analysis of medical records was performed. The study was designed in two branches: (1) the comparison of patients with hypertension (HTN group) and without;(2) the comparison of patients with BMI ≥ 25 and patients with BMI < 25. Statistical analysis with the usage of appropriate tests was conducted. Results. No differences in survival between studied groups in the two branches were determined, even after subdividing into adjuvant and palliative types of treatment. Patients with HTN were more likely to be older, have diabetes and be diagnosed without distant metastases. BMI, ACEIs/ARBs use, diabetes, CRP/lymphocyte ratio (CLR) and AJCC IIb stage influenced survival. Patients with overweight/obesity were more likely to have an autoimmune disease, metastases in ≥ 4 lymph nodes (N2), tumour size between 2 and 4 cm (T2) and experience neutropenia as side effect of palliative chemotherapy. Higher BMI and CRP level influenced survival. Conclusions. The exact effect of ACEIs/ARBs on cancerogenesis should be further studied. CLR appears to be a feasible marker for prognosis in PC.

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“…In patients with PDAC, antihypertensive drugs, including beta-blockers, appear to lack a clear antitumor effect [82], although there are few clinical and laboratory studies on beta-blockers [83].…”

Section: Crosstalk In Pancreatic Cancermentioning

confidence: 99%

The Crosstalk between Nerves and Cancer—A Poorly Understood Phenomenon and New Possibilities

Benzaquen,

Lawrence,

Taussky

et al. 2024

Cancers

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Introduction: Crosstalk occurs between nerve and cancer cells. These interactions are important for cancer homeostasis and metabolism. Nerve cells influence the tumor microenvironment (TME) and participate in metastasis through neurogenesis, neural extension, and axonogenesis. We summarized the past and current literature on the interaction between nerves and cancer, with a special focus on pancreatic ductal adenocarcinoma (PDAC), prostate cancer (PCa), and the role of the nerve growth factor (NGF) in cancer. Materials/Methods: We reviewed PubMed and Google Scholar for the relevant literature on the relationship between nerves, neurotrophins, and cancer in general and specifically for both PCa and PDAC. Results: The NGF helped sustain cancer cell proliferation and evade immune defense. It is a neuropeptide involved in neurogenic inflammation through the activation of several cells of the immune system by several proinflammatory cytokines. Both PCa and PDAC employ different strategies to evade immune defense. The prostate is richly innervated by both the sympathetic and parasympathetic nerves, which helps in both growth control and homeostasis. Newly formed autonomic nerve fibers grow into cancer cells and contribute to cancer initiation and progression through the activation of β-adrenergic and muscarinic cholinergic signaling. Surgical or chemical sympathectomy prevents the development of prostate cancer. Beta-blockers have a high therapeutic potential for cancer, although current clinical data have been contradictory. With a better understanding of the beta-receptors, one could identify specific receptors that could have an effect on prostate cancer development or act as therapeutic agents. Conclusion: The bidirectional crosstalk between the nervous system and cancer cells has emerged as a crucial regulator of cancer and its microenvironment. Denervation has been shown to be promising in vitro and in animal models. Additionally, there is a potential relationship between cancer and psychosocial biology through neurotransmitters and neurotrophins.

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The relationships between antihypertensive medications and the overall survival of patients with pancreatic cancer: a systematic review and meta-analysis

Cited by 6 publications

References 39 publications

Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients—A Single Center Analysis of 2323 Patients within the Last Decade

Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients—A Single Center Analysis of 2323 Patients within the Last Decade

The prevalence and impact of overweight and hypertension among patients with pancreatic cancer

The Crosstalk between Nerves and Cancer—A Poorly Understood Phenomenon and New Possibilities

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