The relationships between low grade inflammation, demographic and clinical characteristics in patients with obsessive compulsive disorder

Ekinci, Aslı; Ekinci, Okan

doi:10.5455/apd.256532

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Mean CRP in the OCD group exceeded this level despite no comorbid depression (mild symptoms were present in some); this relationship was also independent of BMI, age or sex. To date, only one cross‐sectional study has examined levels of CRP levels in OCD patients, which also revealed elevations in patients (13). Despite the independent associations of OCD with CRP and the gut microbiome profile, respectively, CRP levels and the observed taxa differences were not correlated.…”

Section: Discussionmentioning

confidence: 99%

“…Beyond this, current theories describing the pathophysiological mechanism of OCD may also be modulated by the gut microbiome (11). In particular, inflammation is a leading theory linking psychiatric conditions and the gut microbiome, and given that there is some evidence of immune dysregulation in OCD (12,13), this line of research should be pursued.…”

Section: Introductionmentioning

confidence: 99%

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The gut microbiome and inflammation in obsessive‐compulsive disorder patients compared to age‐ and sex‐matched controls: a pilot study

Turna

Kaplan

Anglin

et al. 2020

Acta Psychiatr Scand

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The gut microbiome and inflammation in obsessive-compulsive disorder patients compared to age-and sex-matched controls: a pilot study. Objective: To compare the gut microbiome profile (by way of taxon analysis and indices of band a-diversity) and inflammatory markers (C-reactive protein [CRP], interleukin-6[IL-6] and tumour necrosis factor-a [TNF-a]) of obsessive-compulsive disorder (OCD) outpatients and non-psychiatric community controls. Methods: We collected morning stool and blood samples from 21 nondepressed, medication-free OCD patients and 22 age-and sex-matched non-psychiatric community controls. Microbiota analysis was performed using Illumina sequencing of the V3 region of 16S rRNA; serum CRP samples were analysed using immunoturbidimetry and plasma IL-6/TNF-a were examined by high-sensitivity ELISA. Multiple comparisons were corrected for using the false discovery rate (a = 0.05). Results: Compared to controls, the OCD group presented lower species richness/evenness (a-diversity, Inverse Simpson) and lower relative abundance of three butyrate producing genera (Oscillospira, Odoribacter and Anaerostipes). Compared to controls, mean CRP, but not IL-6 and TNF-a, was elevated OCD patients. CRP revealed moderate to strong associations with psychiatric symptomatology. Conclusion: To our knowledge, this is the first investigation of the gut microbiome in OCD. In addition, our findings lend further support for the potential association of inflammation and OCD. These results suggest the gut microbiome may be a potential pathway of interest for future OCD research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%