The Relationships between Serum sTWEAK, FGF-23 Levels, and Carotid Atherosclerosis in Renal Transplant Patients

Güngör, Özkan; Kısmalı, Erkan; Şişman, Ali Rιza; Kırçelli, Fatih; Carrero, Juan Jesús; Tatar, Erhan; Aşçı, Gülay; Töz, Hüseyin

doi:10.3109/0886022x.2012.734890

Cited by 20 publications

(16 citation statements)

References 22 publications

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“…However, this association was lost in other cohorts and, indeed, positively association has been reported in patients after renal transplantation [21]. This contradictory data could be due to the presence of concomitant therapies used in those patients [21]. Now, we confirmed in a large population study that sTWEAK levels were independently and negatively associated with c-IMT in subjects free from clinical cardiovascular disease.…”

Section: Discussionsupporting

confidence: 63%

“…sTWEAK concentrations has been negatively associated with c-IMT in patients with chronic kidney disease [17e19] and in asymptomatic subjects [11], even after adjustment for cardiovascular risk factors and inflammatory biomarkers. However, this association was lost in other cohorts and, indeed, positively association has been reported in patients after renal transplantation [21]. This contradictory data could be due to the presence of concomitant therapies used in those patients [21].…”

Section: Discussionmentioning

confidence: 88%

“…Thus, c-IMT was inversely associated to sTWEAK in asymptomatic subjects [11] and in patients with chronic kidney disease [17e19]. However, this association has not been confirmed in other patient populations and, indeed, positive correlation between sTWEAK and c-IMT has been reported [20,21]. On the other hand, it has been reported that sTWEAK concentrations are negatively associated with flowmediated dilation (FMD) in patients with CKD, persisting after adjustment for factors related to FMD [17,22,23].…”

Section: Introductionmentioning

confidence: 92%

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Soluble TWEAK levels predict the presence of carotid atherosclerotic plaques in subjects free from clinical cardiovascular diseases

et al. 2015

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 92%

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Soluble TWEAK levels predict the presence of carotid atherosclerotic plaques in subjects free from clinical cardiovascular diseases

et al. 2015

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“…Numerous low-powered cross-sectional ultrasound studies of carotid arteries have been performed in patients with renal transplants (28)(29)(30)(31)(32). The vast majority of these studies considered isolated biomarkers (mainly biomarkers of inflammation) (29,31,32) or just a limited set of purported risk factors. Longitudinal studies have several advantages over cross-sectional studies for exploring causation.…”

Section: Discussionmentioning

confidence: 99%

“…Among nonclassic risk factors, CRP (9) and biomarkers of CKD-MBD (10) undergo dramatic changes after transplantation, and FGF23 and 1,25(OH) 2 vitamin levels approach the normal range in most patients, whereas serum PTH often remains mildly to moderately elevated (27). Numerous low-powered cross-sectional ultrasound studies of carotid arteries have been performed in patients with renal transplants (28)(29)(30)(31)(32). The vast majority of these studies considered isolated biomarkers (mainly biomarkers of inflammation) (29,31,32) or just a limited set of purported risk factors.…”

Section: Discussionmentioning

confidence: 99%

A Longitudinal Study of Inflammation, CKD-Mineral Bone Disorder, and Carotid Atherosclerosis after Renal Transplantation

Yılmaz

Sönmez

Sağlam

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives The role of reversibility of nontraditional risk factors, like inflammation and CKDmineral bone disorder, in the reduction of cardiovascular risk after renal transplantation is still scarcely defined.Design, setting, participants, and measurements The longitudinal relationship between C-reactive protein, CKDmineral bone disorder biomarkers, and intima media thickness was investigated in a series of 178 patients (age=32610 years) with stage 5 CKD maintained on chronic dialysis who underwent echo-color Doppler studies of the carotid arteries before and after renal transplantation. Smokers and patients with diabetes were excluded from the study. In all patients, immunosuppression was performed by a standard regimen on the basis of calcineurin inhibitors. Healthy controls were specifically selected to match the age and sex distribution of the patients. Biochemical and intima media thickness assessments were repeated 6 months after transplantation.Results Before transplantation, intima media thickness in patients with stage 5 CKD on dialysis (average=0.960.2 mm) was higher (P,0.001) than in well matched healthy controls (0.660.1 mm) and reduced substantially (222%; 95% confidence interval, 224% to 220%) after transplantation (P=0.001). GFR (multivariable-adjusted b=0.23; P,0.001), C-reactive protein (b=0.15; P,0.001), and fibroblast growth factor 23 (b=0.28; P,0.001) were the strongest independent correlates of intima media thickness before transplantation. Similarly, longitudinal changes in the same biomarkers were the sole independent correlates of simultaneous changes in intima media thickness (C-reactive protein: b=0.25; fibroblast growth factor 23: b=0.26; P,0.001 for both) after renal transplantation. The evolution of intima media thickness after transplantation was largely independent of classic risk factors, including BP, LDL cholesterol, and insulin resistance, as measured by homeostatic model assessment.Conclusions Intima media thickness improves after renal transplantation. Such an improvement associates with parallel changes in serum C-reactive protein and fibroblast growth factor 23. These observations are in keeping with the hypothesis that the decline in cardiovascular risk after transplantation, in part, depends on partial resolution of nontraditional cardiovascular risk factors, like inflammation and CKD-mineral bone disorder.

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sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy

Silva‐Candal

Custodia

López‐Dequidt

et al. 2022

Ann Clin Transl Neurol

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Objective Leukoaraiosis (LA) refers to white matter lesions of undetermined etiology associated with the appearance and worsening of vascular pathologies. The aim is to confirm an increased frequency and intensity of LA in symptomatic patients with neurovascular pathology compared with asymptomatic subjects, and its association with circulating serum levels of soluble tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK). Methods An observational study was conducted in which two groups of patients were compared. Group I (N = 242) comprised of asymptomatic subjects with arterial hypertension and/or diabetes or with a history of transient ischemic attacks, and Group II (N = 382) comprised patients with lacunar stroke or deep hemispheric intracerebral hemorrhage (ICH) of hypertensive origin. Serum levels of sTWEAK were analyzed and correlated with prevalence and intensity of LA according to the Fazekas scale. Results The prevalence of LA was higher in symptomatic (85.1%) versus asymptomatic patients (62.0%). Logistic regression model showed a significant relation of LA with neurovascular pathologies (OR: 2.69, IC 95%: 1.10–6.59, p = 0.003). When stratified according to the Fazekas scale, LA of grade II (OR: 3.53, IC 95%: 1.10–6.59, p = 0.003) and specially grade III (OR: 4.66, 95% CI: 1.09–19.84, p = 0.037) showed correlation with neurovascular pathologies. Increased sTWEAK levels were found in the symptomatic group in all LA grades (p < 0.0001), and associated with 5.06 times more risk of presenting clinical symptoms (OR: 5.06, 95% CI: 2.66–9.75, p < 0.0001). Interpretation LA showed a higher prevalence in patients with symptomatic lacunar stroke or deep hemispheric ICH. There is an association between sTWEAK levels and LA degree.

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The Relationships between Serum sTWEAK, FGF-23 Levels, and Carotid Atherosclerosis in Renal Transplant Patients

Cited by 20 publications

References 22 publications

Soluble TWEAK levels predict the presence of carotid atherosclerotic plaques in subjects free from clinical cardiovascular diseases

Soluble TWEAK levels predict the presence of carotid atherosclerotic plaques in subjects free from clinical cardiovascular diseases

A Longitudinal Study of Inflammation, CKD-Mineral Bone Disorder, and Carotid Atherosclerosis after Renal Transplantation

sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy

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