The Relationships Between Total, Acid, and Neutral Chlorides of Gastric Juice

Gray, John S.; Bucher, Gladys R.; Harman, Harry H.

doi:10.1152/ajplegacy.1941.132.2.504

Cited by 20 publications

(3 citation statements)

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“…3); the pouches responded to meals as though they were vagally innervated. The total acidity of the juice secreted after meals rapidly approached that accepted as maximal for the dog (approximately 0-6 % (w/v) HCI; Gray, Bucher & Harman, 1941) and remained high even when the volume rate of secretion declined towards the end. It is doubtful whether any stimulation of pepsin output occurred; the concentration fell to low levels as secretion began and remained there (Fig.…”

Section: The Effect Of Portal Venoms Ligationmentioning

confidence: 83%

Gastric secretory responses after portal venous ligation

Gregory¹

1958

The Journal of Physiology

118

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It was shown by Lebedinskaya (1932) that the creation of an Eck fistula in dogs provided with Pavlov pouches was followed by a remarkable change in the secretory response to meals. The volume and acidity of the juice increased greatly and the duration of secretion was prolonged; the output of pepsin was slightly decreased. These changes attained their maximal extent about four weeks after the operation and were apparently permanent thereafter. She believed that they were due to an impairment of the detoxicating functions of the liver which resulted from the diversion of its portal blood supply into the systemic circulation, and saw in her results a possible explanation for clinical reports that gastric hypersecretion occurred in cirrhosis of the liver.Gerez & Weiss (1936) repeated Lebedinskaya's experiments and obtained virtually identical results. They, however, referred to reports that secretin extracts were less effective in stimulating pancreatic secretion when injected into the portal blood stream than when they were injected into a peripheral vein, suggesting that some retention or destruction by the liver normally occurred during passage of the hormone through this organ. Gerez & Weiss suggested that this was true also for stimulants of gastric secretion released into the portal blood during digestion of a meal, so that after creation of an Eck fistula they appeared in greater quantity in the systemic blood during digestion.These observations are of great potential significance in relation to the mechanisms by which gastric secretion is stimulated during digestion in normal circumstances; but before any useful interpretation can be made of them from this point of view further experimental analysis is necessary, if only for the following reasons: (1) the gastric pouches used in the above experiments were vagally innervated, so that the extent of humoral stimulation before and after the creation of the Eck fistula cannot be estimated; and (2) it is generally agreed that the liver of the Eck fistula dog undergoes considerable

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Section: The Effect Of Portal Venoms Ligationmentioning

confidence: 83%

Gastric secretory responses after portal venous ligation

Gregory¹

1958

The Journal of Physiology

118

View full text Add to dashboard Cite

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“…Reed (1977), however, suggested that these presumed differential effects of the gastric inhibitors may in fact only be a consequence of the well known relationship between [H+] and flow, in which [H+] increases asymptotically with flow rate (Hollander, 1932;Gray, Bucher & Harman, 1941;Teorell, 1947;Hollander, 1952;Nordgren, 1963;Makhlouf, MacManus & Card, 1966). Detailed evidence of the relationship between [H+] and flow of gastric juice during inhibition of secretion is lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Anticholinergics have been claimed to reduce primarily the volume of gastric juice, whilst histamine H2-receptor antagonists are claimed to cause a primary B. H. HIRST AND OTHERS reduction in the [H+] (Wormsley, 1977), and would thus be expected to be of greater therapeutic use. Reed (1977), however, suggested that these presumed differential effects of the gastric inhibitors may in fact only be a consequence of the well known relationship between [H+] and flow, in which [H+] increases asymptotically with flow rate (Hollander, 1932;Gray, Bucher & Harman, 1941;Teorell, 1947;Hollander, 1952;Nordgren, 1963;Makhlouf, MacManus & Card, 1966). Detailed evidence of the relationship between [H+] and flow of gastric juice during inhibition of secretion is lacking.…”

Section: Introductionmentioning

confidence: 99%