The relationships of irisin with bone mineral density and body composition in PCOS patients

Abstract

Objective Our study aims to assay the irisin level and investigate the relationships of irisin level with body mass index (BMI), body composition and bone metabolism in the polycystic ovary syndrome (PCOS) and control women.Methods Fifty two PCOS and 39 control women were recruited. Serum sex hormone, fasting insulin and C-peptide were tested. Fasting serum irisin and adiponectin were measured with enzyme-linked immunosorbent assay. Body composition and bone mineral density were assayed by dual energy X-ray absorptiometry.Results Polycystic ovary syndrome women showed different body compositions compared with controls. Serum irisin level of PCOS did not show significant difference compared with controls although it was decreased. The level of adiponectin in PCOS patients was significantly reduced. BMI had no correlation with irisin level. It indicated a positive correlation between serum irisin levels and bone mineral density in the control group and a negative correlation in the PCOS group after BMI and age adjusted. Furthermore, total lean mass has a significant effect on irisin concentration in the PCOS group. There are no correlations between adiponection and body compositions and bone mineral density in both groups.Conclusions The abnormal body composition in PCOS may contribute to the circulation irisin. The crosstalk of irisin in different organs was found and may be related to disease development in PCOS.

Serum Irisin and Leptin Levels in Obese and Non-Obese Women With Polycystic Ovary Syndrome With Reference to Glucose Homeostasis

“…Serum irisin level of PCOS women did not show a significant difference compared with control subjects although it was decreased, which is consistent with the finding of Gouni et al [44,45] and Shanshan Gao [9]. But there were significant higher differences between obese and non-obese groups both control and PCOS this explained the correlation with BMI.…”

“…Which could be related to the adipocyte-derived hormone adiponectin concentrations which are positively correlated with insulin sensitivity [9].…”

“…Most PCOS patients suffer oligo-or anovulation, infertility, dysfunctional uterine bleeding, hyperandrogenism, and/or hirsutism [4 -9]. In addition, it was estimated that>42% of women with PCOS in the United States are overweight or obese, and have a high risk of developing type 2 diabetes (T2D), atherosclerosis, and cardiovascular events [4,[8][9][10][11][12].…”

“…PCOS subjects also appear to have a high risk of suffering lipid metabolism disorder [9,13]. Although the root causes of PCOS remain to be identified, a popular hypothesis considers androgen excess as the primary defect in PCOS [14,15] and that hyperinsulinemia in PCOS patients could be associated with hyperandrogenism [4,9,[16][17][18].…”

“…Although the root causes of PCOS remain to be identified, a popular hypothesis considers androgen excess as the primary defect in PCOS [14,15] and that hyperinsulinemia in PCOS patients could be associated with hyperandrogenism [4,9,[16][17][18]. The hyperinsulinemia may cause hyperandrogenism by inhibiting hepatic synthesis of SHBG and by binding insulin like growth factor-1 (IGF-1) receptors in the ovary leading to increased androgen production by thecal cells.…”