The relative biological effectiveness for carbon, nitrogen, and oxygen ion beams using passive and scanning techniques evaluated with fully 3D silicon microdosimeters

Abstract

These SOI microdosimeters with well-defined three-dimensional (3D) SVs have applicability in characterizing heavy ion radiation fields and measuring lineal energy deposition with sub-millimeter spatial resolution. It has been shown that the dose-mean lineal energy increased significantly at the distal part of the BP and SOBP due to very high LET particles. Good agreement was observed for the experimental and simulation results obtained with silicon microdosimeters in N and O ion beams, confirming the potential application of SOI microdosimeter with 3D SV for quality assurance in charged particle therapy.

Fabrication and First Characterization of Silicon-Based Full 3-D Microdosimeters

“…Many working devices have been fabricated and fully characterized at HIT facilities. The first results are in excellent agreement with those obtained from TEPCs [20]. In this paper, we present, review, and discuss the overall technology investigation and the challenges throughout the prototype runs, forming a basis for a future technology plan at manufacture level.…”

Single Molecule Localization Microscopy Analyses of DNA-Repair Foci and Clusters Detected Along Particle Damage Tracks

“…N-ions are also generated during hadron radiation therapy and may significantly contribute to the patients' absorbed dose [77]. Nitrogen ion beams have been also studied as promising particles for radiotherapy [78].…”

Neutron activation of gadolinium for ion therapy: a Monte Carlo study of charged particle beams

“…The last column is RBE weighted captures normalized to protons. RBE RBE value reference Particle 5 to 10 cm (SOBP) Gd neutron captures reactions per RBE × Gy (captures/GyE) Normalized RBE weighted Gd neutron capture reactions 4.25 Goldstein et al 42 Argon 1.2 × 10 5 0.06 3.75 Blakely et al 44 Silicon 1.3 × 10 5 0.07 3.5 Goldstein et al 42 Neon 1.9 × 10 5 0.10 3.25 Tran et al 45 Oxygen 2.3 × 10 5 0.12 3 Tran et al 45 Nitrogen 3.0 × 10 5 0.15 2.75 Goldstein et al 42 Carbon 3.8 × 10 5 0.20 1.5 Goldstein et al 42 Helium 2.5 × 10 6 1.3 1.1 Tepper et al 43 Proton 1.9 × 10 6 1.0 2 Holzscheiter et al 46 Antiproton 1.9 × 10 7 10 …”

“…Helium exhibits depth dose characteristics identical to protons along the longitudinal depth, but has reduced lateral scattering due to its larger mass. This advantage is interesting as the LET of helium ions is higher than that of protons 45 . Distinct from carbon and other heavy ions, helium produces little to no fragmentation tail and therefore treatments are capable of gaining the benefit of a higher RBE value while also maintaining a sharp dose fall-off after the tumor 48 .…”