The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo

Slug inhibition increases radiosensitivity of nasopharyngeal carcinoma cell line C666‑1

“…However, the mechanisms underlying the radioresistance of cancer remain unclear. PUMA is a pivotal protein in apoptosis and it has been suggested that PUMA may increase sensitivity to radiation-induced apoptosis in different types of cancer (15,33,34). Slug is a suppressor of PUMA transcription, which inhibits the expression of PUMA resulting in cell survival (35).…”

Mechanism of 5-Fluorouracil-Induced Apoptosis on Cultured Corneal Endothelial Cells

“…The intrinsic apoptosis pathway activates caspases 3 and 9, in response to signals originating from mitochondria [18]. The intrinsic pathway relies on extrinsic signals to promote cell death in a cell-and tissue-dependent manner following DNA damage [20]. Evidence has shown that treatment with 5-FU increased the expression of Fas, which belongs to the death receptor pathway [21].…”

The effects of antioxidants on gene expression following gamma-radiation (GR) and proton radiation (PR) in mice in vivo

“…A total of 15 genes belonging to the class of "apoptosis regulator activity" (GO: 00176) were either over-( Table 1) or underexpressed (Table 2) in the spleen of mice fed AOX diet compared with mice fed SD. Differentially expressed candidate genes following AOX diet that warranted further investigation included protein C, 18,19 xiap, [20][21][22][23] bcl-x, 24 and trail-r, [25][26][27][28][29][30] which have been shown to modulate radiation-induced cell death and injury. AOX diet inhibits apoptosis in the white pulp of the spleen following GR.…”