The Relative Number of Marrow Reticulocytes

On the in vivo action of erythropoietin: a quantitative analysis

“…At 24 hr, about one-half the marrow reticulocytes were so displaced. This erythropoietin effect has been previously described with in vitro perfusion (16)(17)(18) and in vivo studies (7)(8)(9). In addition to providing an exaggerated impression of red cell production in the peripheral blood, the reticulocyte shift is also associated with an increase in the amount of hemoglobin synthesis occurring in the peripheral blood (from 16% at day 0 to 43% after 3 days of stimulation).…”

“…Erythropoietin has been demonstrated in vivo to regulate the entry of precursor cells into the maturing erythroid pool (1,2), to affect the mitotic interval (3,4) and the rate of hemoglobin synthesis in the individual cell (5,6), and to alter the release of the marrow reticulocyte into circulation (7)(8)(9). This study attempts to evaluate the quantitative importance of these different effects of erythropoietin and to provide an integrated picture of erythropoietic response to erythropoietin in an animal model.…”

Quantitative Measurement of Hematopoietic Cells of the Marrow1

“…Not only the erythroid-myeloid ratio, but also the myelocytic differential count remained essentially unchanged. Evidence has been presented elsewhere (11), however, that the destruction of nucleated cells is appreciably greater than that of non-nucleated erythrocytes in the suspension.…”

Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia

“…Both the number of these cells and their relative reticulum content progressively increased as the hematocrit was lowered. Reiff, Nutter, Donohue, and Finch (20) Before the concept of a prolongation of the circulating reticulocyte maturation time is accepted as the lone cause of the discrepancy between the absolute reticulocyte counts and other measurements of marrow production, it is important to exclude other disturbances in reticulocyte maturation. In small animals, Ambs (22) (17), but also any major loss of short-lived cells in the present studies should have been reflected by a major discrepancy between the plama iron turnover and the phlebotomy production measurement.…”