The Relative Role of Caspase-Dependent and Independent Apoptosis of Endothelial and Pulmonary Epithelial Cells, Induced by T/Hs Lymph, Varies by Celltype

Lu, Qikun; Caputo, Frank; McCracken, B A; Watkins, Anthony C.; Xu, Dan; Deitch, Edwin A.

doi:10.1097/00024382-200606001-00166

Shock

2006

DOI: 10.1097/00024382-200606001-00166

|View full text |Cite

The Relative Role of Caspase-Dependent and Independent Apoptosis of Endothelial and Pulmonary Epithelial Cells, Induced by T/Hs Lymph, Varies by Celltype

Qikun Lu¹,

Frank Caputo²,

B A McCracken³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2007

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Sodium Butyrate Prevents Lethality of Severe Sepsis in Rats

Zhang

Yao

et al. 2007

Shock

View full text Add to dashboard Cite

This study was performed to investigate a novel strategy to pharmacologically inhibit high-mobility group box 1 protein (HMGB1) expression with sodium butyrate, a short-chain fatty acid. Using a sepsis model induced by cecal ligation and puncture (CLP), 100 male Wistar rats were randomly divided into 4 groups as follows: control group (10 rats), sham operation group (10 rats), CLP group (further randomized into 2, 6, 12, 24, 48, and 72 h post-CLP subgroups, each 10 rats), and sodium butyrate treatment group (further randomized into 12 and 24 h post-CLP subgroups, each 10 rats). Animals of all groups were killed at designated time points, and blood and tissue samples from livers, lungs, kidneys, and small intestines were harvested to determine organ damage-related variables, and HMGB1 mRNA expression was assessed by the reverse-transcription-polymerase chain reaction. In addition, we observed the effect of treatment with sodium butyrate on survival rate in septic rats. The results showed that early treatment with sodium butyrate can markedly reduce serum alanine aminotransferase, creatinine levels at 12 h, and pulmonary myeloperoxidase activity at 24 h post-CLP, and significantly improve the 1- to 6-day survival rates in animals subjected to CLP (P < 0.05-0.01). These findings suggest that HMGB1 is excessively expressed and produced in sepsis. Sodium butyrate can markedly inhibit HMGB1 mRNA expression and may have protective effect on multiple organ damage in sepsis.

show abstract

Sodium Butyrate Prevents Lethality of Severe Sepsis in Rats

Zhang

Yao

et al. 2007

Shock

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The Relative Role of Caspase-Dependent and Independent Apoptosis of Endothelial and Pulmonary Epithelial Cells, Induced by T/Hs Lymph, Varies by Celltype

Cited by 1 publication

References 0 publications

Sodium Butyrate Prevents Lethality of Severe Sepsis in Rats

Sodium Butyrate Prevents Lethality of Severe Sepsis in Rats

Contact Info

Product

Resources

About